A mild and efficient method for one-step α-haloacetalization of acetophenones using 1,3-dihalo-5,5-dimehtylhydantoin in ethylene glycol was written by Zheng, Zu Biao;Li, Zhong Zhou;Han, Bing Bing;He, Zai Ming;Shi, Teng Fei;Cheng, Peng. And the article was included in Tetrahedron Letters in 2015.Recommanded Product: 3418-21-1 This article mentions the following:
A mild and efficient method that could directly prepare α-haloacetal acetophenones from various acetophenones with 1,3-dihalo-5,5-dimehtylhydantoin (DBDMH/DCDMH) and ethylene glycol in good yields without catalysts was reported. The effects of solvents, 1,3-dihalo-5,5-dimehtylhydantoin, and reaction temperature were investigated. Under the optimal condition, most of α-haloacetal acetophenones were obtained in 65-97% yields. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Recommanded Product: 3418-21-1).
2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: 3418-21-1
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem