Chiral Aluminum Complex Controls Enantioselective Nickel-Catalyzed Synthesis of Indenes: C-CN Bond Activation was written by Zhang, Tao;Luan, Yu-Xin;Zheng, Su-Juan;Peng, Qian;Ye, Mengchun. And the article was included in Angewandte Chemie, International Edition in 2020.Synthetic Route of C47H38O4 This article mentions the following:
A chiral aluminum complex controlled, enantioselective nickel-catalyzed domino reaction of aryl nitriles and alkynes proceeding by C-CN bond activation was developed. The reaction provides various indenes, bearing chiral all-carbon quaternary centers, under mild reaction conditions in yields of 32 to 91% and ee values within the 73-98% range. The reaction mechanism and aspects of stereocontrol were investigated by DFT calculations Thus, e.g., domino C-CN bond activation/insertion reaction of nitrile I with 4-octyne in presence of Ni(cod)2, tris(4-methoxyphenyl)phosphine, a chiral TADDOL and Al(iBu)3 afforded indene II (86%, 92% ee). In the experiment, the researchers used many compounds, for example, ((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(di(naphthalen-1-yl)methanol) (cas: 171086-52-5Synthetic Route of C47H38O4).
((4S,5S)-2,2-Dimethyl-1,3-dioxolane-4,5-diyl)bis(di(naphthalen-1-yl)methanol) (cas: 171086-52-5) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Synthetic Route of C47H38O4
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem