Process improvement of intermediate synthesis of gemcitabine was written by Zhang, Gaofeng;Chen, Guijun. And the article was included in Shandong Huagong in 2017.Recommanded Product: 15186-48-8 This article mentions the following:
The selective protection of 1, 2 and 5, 6 hydroxyl groups, sodium periodate oxidation, and then Et bromodifluoroacetate in zinc catalyzed Reformatsky reaction, synthetised the key intermediate of gemcitabine, Et (3R, S)-2,2-difluoro-3-hydroxy-3-(2,2-dimethyldioxolan-4-yl) propionate, the process of protection of hydroxyl, oxidation, and Reformatsky reaction of process improvement, the result shows that improving the selectivity of the reaction, thus improving the yield and quality, reduce the production cost. In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8Recommanded Product: 15186-48-8).
(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: 15186-48-8
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem