Mass spectrometry of the acetal derivatives of selected generally recognized as safe listed aldehydes with ethanol, 1,2-propylene glycol and glycerol was written by Woelfel, Keith;Hartman, Thomas G.. And the article was included in ACS Symposium Series in 1998.Application In Synthesis of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol This article mentions the following:
The FEMA-GRAS list offers flavor chemists a repertoire of nearly 2000 chems. for use in compounding natural and synthetic flavors for the U.S. marketplace. Aldehydes constitute an important class of these potential flavorants and are widely utilized to impart specific nuances. Alcs. such as ethanol, 1,2-propylene glycol and glycerol are commonly employed as solvents in compounded flavor systems due to their low odor and miscibility in a wide range of aqueous and organic matrixes. However, alcs. and aldehydes react rapidly under anhydrous conditions to form acetal derivatives which often possess different sensory properties. This well known reaction is reversible and its equilibrium is influenced by time, temperature, pH and moisture content. Mass spectra of acetals are currently under represented in com. databases and few literature references are available. Our investigation involved a systematic mass spectrometric study of the acetal derivatives of selected GRAS aldehydes reacted with ethanol, 1,2-propylene glycol and glycerol. Aldehydes from different chem. classes representing saturated and unsaturated aliphatics, aromatics, heterocyclics, terpenoids and others were included for characterization. The corresponding acetals were synthesized, analyzed by GC-MS in electron ionization mode and their retention indexes on a non-polar (polydimethylsiloxane) capillary column were determined A database of mass spectra was produced which includes many previously unreported species. In total, over 60 individual mass spectra were recorded. The characteristic mass spectral fragmentation pathways for each class of acetal are described. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2Application In Synthesis of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol).
2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem