Enantioselective Aldehyde α-Nitroalkylation via Oxidative Organocatalysis was written by Wilson, Jonathan E.;Casarez, Anthony D.;MacMillan, David W. C.. And the article was included in Journal of the American Chemical Society in 2009.Related Products of 62563-07-9 This article mentions the following:
The first enantioselective organocatalytic α-nitroalkylation of aldehydes R1CH2CHO [R1 = Me, n-Bu, cyclohexyl, PhCH2O(CH2)3, PhCO2(CH2)4, etc.] with silyl nitronates R2CH:N+(O–)OSiR33 [R2 = H, Me, Et, MeO2CCH2CH2, cyclohexyl, etc.; SiR33 = SiMe3, Si(i-Pr)3, Si(t-Bu)Me2, etc.] has been accomplished. The aforementioned process involves the oxidative coupling of an enamine intermediate, generated transiently via condensation of an amine catalyst with an aldehyde, with a silyl nitronate to produce a β-nitroaldehyde. Two methods, one that furnishes the syn β-nitroaldehyde and a second that provides access to the anti isomer, have been developed. Data are presented to support a hypothesis that explains this phenomenon in terms of a silyl group-controlled change in mechanism. Finally, a three-step procedure for the synthesis of both syn- and anti-α,β-disubstituted β-amino acids is presented. In the experiment, the researchers used many compounds, for example, 2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9Related Products of 62563-07-9).
2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Related Products of 62563-07-9
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem