One-pot α-bromoacetalization of carbonyl compounds was written by Visweswariah, Sandhya;Prakash, G.;Bhushan, Vidya;Chandrasekaran, S.. And the article was included in Synthesis in 1982.Safety of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:
Alkanones and cycloalkanones were treated with HOCH2CH2OH and PhN+Me3 Br3– to yield α-bromo ketone ethylene ketals. Thus, PhN+Me3 Br3– was added to Me2CO, HOCH2CH2OH, and THF, and the mixture was stirred ≥ 20 h at room temperature to give bromoacetone ethylene ketal. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Safety of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).
2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Safety of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem