Synthesis 2-bromomethyl-2-aryl-1,3-dioxolanes – the precursors of adrenoceptor blockers was written by Vershinin, S. S.;Kotlov, V. M.;Klimakov, V. S.;Mindiyarova, E. R.;Zorin, V. V.. And the article was included in Bashkirskii Khimicheskii Zhurnal in 2011.Reference of 3418-21-1 This article mentions the following:
The effective method for preparation of 2-bromomethyl-2-R-1,3-dioxolanes I [R = Ph, 4-ClC6H4], the precursors of adrenoceptor blockers α and β, is developed. Intermediate 2-methyl-2-R-1,3-dioxolanes were obtained in high yields (up to 95%) via microwave-assisted heterocyclization of RC(O)Me with HOCH2CH2OH, which proceeds 12 times faster than heat-assisted reactions. Bromination of the resultant intermediates with mol. bromine selectively gave I [R = Ph, 4-ClC6H4] in 98 and 96% yields, resp. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Reference of 3418-21-1).
2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Reference of 3418-21-1
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem