Verhelst, Steven H. L. et al. published their research in Journal of Organic Chemistry in 2003 |CAS: 38838-06-1

The Article related to chiral polyhydroxylated indolizidine quinolizidine preparation, Alkaloids: Alkaloids Containing One Nitrogen Atom At A Bridgehead and other aspects.Synthetic Route of 38838-06-1

On December 12, 2003, Verhelst, Steven H. L.; Martinez, Baltasar Paez; Timmer, Mattie S. M.; Lodder, Gerrit; Van der Marel, Gijsbert A.; Overkleeft, Herman S.; Van Boom, Jacques H. published an article.Synthetic Route of 38838-06-1 The title of the article was A Short Route toward Chiral, Polyhydroxylated Indolizidines and Quinolizidines. And the article contained the following:

In this paper, a rapid route toward functionalized bicyclic alkaloids is presented. In only three steps, an easily accessible carbohydrate derivative was converted into iodomethyl indolizidine I, which can equilibrate to the corresponding iodoquinolizidine II. We provide strong evidence that this equilibration proceeds via an aziridinium ion intermediate. Furthermore, nucleophilic substitution of the iodomethyl indolizidine as well as the aziridinium intermediate gives access to highly functionalized indolizidine and quinolizidine alkaloids. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Synthetic Route of 38838-06-1

The Article related to chiral polyhydroxylated indolizidine quinolizidine preparation, Alkaloids: Alkaloids Containing One Nitrogen Atom At A Bridgehead and other aspects.Synthetic Route of 38838-06-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem