The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: H-Trp-OMe.HCl( cas:7524-52-9 ) is researched.Product Details of 7524-52-9.Dong, Weizhe; Badir, Shorouk O.; Zhang, Xuange; Molander, Gary A. published the article 《Accessing Aliphatic Amines in C-C Cross-Couplings by Visible Light/Nickel Dual Catalysis》 about this compound( cas:7524-52-9 ) in Organic Letters. Keywords: trimethylsilylmethanamine aryl bromide nickel catalyst regioselective aminoalkylation; aryl methanamine preparation. Let’s learn more about this compound (cas:7524-52-9).
A general aminoalkylation of aryl halides were developed, overcoming intolerance of free amines in nickel-mediated C-C coupling. This transformation features broad functional group tolerance and high efficiency. Taking advantage of the fast desilylation of α-silylamines upon single-electron transfer (SET) facilitated by carbonate, α-amino radicals were generated regioselectively, which then engage in nickel-mediated C-C coupling. The reaction displays high chemoselectivity for C-C over C-N bond formation. Highly functionalized pharmacophores and peptides were also amenable.
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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem