Safety of 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Synthesis of Nitrogen-Containing Heterocycles and Cyclopentenone Derivatives via Phosphine-Catalyzed Michael Addition/Intramolecular Wittig Reaction. Author is Saleh, Nidal; Blanchard, Florent; Voituriez, Arnaud.
The phosphine-catalyzed Michael addition/intramol. Wittig reaction between dialkyl acetylenedicarboxylate and amino carboxaldehyde or amino ester has been developed. This reaction can be rendered catalytic in phosphine by the in situ chemoselective reduction of the phosphine oxide with a silane. This methodol. enables rapid access to a variety of nitrogen-containing heterocycles, which are present in numerous natural products and/or bioactive compounds Either classical heating or microwave conditions give access to the desired products in good yields (15 examples, 60-99% yields). This catalytic methodol. is further applicable to the synthesis of enantioenriched 1H-pyrrole derivatives, with the use of chiral phosphines. Finally, the reaction is extended to the synthesis of a polysubstituted cyclopentenone, starting from butane-2,3-dione as substrate.
As far as I know, this compound(707-61-9)Safety of 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem