New research progress on 3458-28-4 in 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. In an article, author is Deng, Chongyang, once mentioned the application of 3458-28-4, Electric Literature of 3458-28-4, Name is (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, molecular formula is C6H12O6, molecular weight is 180.1559, MDL number is MFCD00799233, category is dioxole. Now introduce a scientific discovery about this category.
A Novel Small Molecule, (E)-5-(2,4-di-tert-butyl-6-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-5 ‘-methyl-7,7 ‘-dimethoxy-4,4 ‘-bibenzo[d][1,3]dioxole-5,5 ‘-dicarboxylate (7k), Alleviates the Development of D-Galactosamine/Lipopolysaccharide-Induced Acute Liver Failure by Inhibiting Macrophage Infiltration and Regulating Cytokine Expression
Acute liver failure (ALF) is a relatively rare liver disorder that leads to the massive death of hepatocytes. Our previous study reported that a novel small-molecule agent, (E)-5-(2,4-di-tert-butyl-6-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-5-methyl-7,7′-dimethoxy-4,4′-bibenzo[d][1,3]dioxole-5,5’-dicarboxylate (7k), possessed potent anti-inflammatory activity. In the present study, we further evaluated the therapeutic effects of 7k on lipopolysaccharide (LPS)-induced ALF and investigated the mechanisms of action. Our results demonstrated that 7k inhibited the migration of RAW264.7 macrophages, blocked the activity of nuclear factor-kappa B protein, and dose-dependently down-regulated the production of interleukin (IL)-1 beta, tumor necrosis factor-alpha, and IL-6 as well as their corresponding mRNAs in RAW264.7 cells. Oral administration of 7k at a dose of 50 mg/kg significantly suppressed the serum level of enzyme activity and prevented the damage of liver tissue in D-galactosamine/LPS-induced ALF. Treatment with 7k also remarkably blocked the increase in the number of CD11b(+)- and CD68(+)-positive cells in the liver, and in vivo nuclear factor-kappa B activity, known to regulate inflammatory responses in many cell types, was effectively inhibited. The serum concentrations and hepatic mRNA expression of proinflammatory cytokines tumor necrosis factor-alpha, IL-1 beta, and IL-6 were markedly downregulated in mice by the treatment of 7k. In summary, 7k alleviated the development and progression of D-galactosamine/LPS-induced ALF by inhibiting macrophage infiltration and regulating the expression of cytokines.
Electric Literature of 3458-28-4, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 3458-28-4.
Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem