Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 22353-34-0, is researched, SMILESS is NC1=CC(=CN=C1)Cl, Molecular C5H5ClN2Journal, Synthesis called Boric Acid Catalyzed Direct Amidation between Amino-Azaarenes and Carboxylic Acids, Author is Yun, Fan; Cheng, Chunhui; Zhang, Jing; Li, Jingxuan; Liu, Xia; Xie, Rui; Tang, Pingwah; Yuan, Qipeng, the main research direction is azaarylamide preparation green chem chemoselective; aminoazaarene carboxylic acid boric acid tetramethylpropanediamine catalyst amidation.Reference of 5-Chloropyridin-3-amine.
A novel and facile boric acid-catalyzed direct amidation between amino-azaarene compounds and carboxylic acids was developed. The amidation proceeded cleanly and provided good to excellent yields of the desired amides. Boric acid is a green and inexpensive catalyst. It was also found that N,N,N’,N’-tetramethylpropane-1,3-diamine acted as an additive accelerating this boric acid-catalyzed amidation. A mixed acid anhydride was postulated to be the active intermediate responsible for this successful amidation. This direct amidation was an atom- and step-economical reaction.
Here is a brief introduction to this compound(22353-34-0)Reference of 5-Chloropyridin-3-amine, if you want to know about other compounds related to this compound(22353-34-0), you can read my other articles.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem