Recommanded Product: 22353-34-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-Chloropyridin-3-amine, is researched, Molecular C5H5ClN2, CAS is 22353-34-0, about The synthesis, structure-toxicity relationship of cisplatin derivatives for the mechanism research of cisplatin-induced nephrotoxicity. Author is Hu, Jing; Wu, Tian-Ming; Li, Hong-Ze; Zuo, Ze-Ping; Zhao, Ying-Lan; Yang, Li.
Cisplatin is a widely used antineoplastic drug, while its nephrotoxicity limits the clin. application. Although several mechanisms contributing to nephrotoxicity are reported, the direct protein targets are unclear. Herein the authors reported the synthesis of 29 cisplatin derivatives and the structure-toxicity relation (STR) of these compounds with MTT assay in human renal proximal tubule cells (HK-2) and pig kidney epithelial cells (LLC-PK1). To the best of the authors’ knowledge, this study represented the 1st report regarding the structure-toxicity relation (STR) of cisplatin derivatives The potency of biotin-pyridine conjugated derivative 3 met the requirement for target identification, and the preliminary chem. proteomics results suggested that it is a promising tool for further target identification of cisplatin-induced nephrotoxicity.
Here is a brief introduction to this compound(22353-34-0)Recommanded Product: 22353-34-0, if you want to know about other compounds related to this compound(22353-34-0), you can read my other articles.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem