Category: dioxole. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about Transition-Metal-Free Deconstructive Lactamization of Piperidines. Author is Romero-Ibanez, Julio; Cruz-Gregorio, Silvano; Sandoval-Lira, Jacinto; Hernandez-Perez, Julio M.; Quintero, Leticia; Sartillo-Piscil, Fernando.
One of the major challenges in organic synthesis is the activation or deconstructive functionalization of unreactive C(sp3)-C(sp3) bonds, which requires using transition or precious metal catalysts. We present here an alternative: the deconstructive lactamization of piperidines without using transition metal catalysts. To this end, we use 3-alkoxyamino-2-piperidones, which were prepared from piperidines through a dual C(sp3)-H oxidation, as transitory intermediates. Exptl. and theor. studies confirm that this unprecedented lactamization occurs in a tandem manner involving an oxidative deamination of 3-alkoxyamino-2-piperidones to 3-keto-2-piperidones, followed by a regioselective Baeyer-Villiger oxidation to give N-carboxyanhydride intermediates, which finally undergo a spontaneous and concerted decarboxylative intramol. translactamization.
Although many compounds look similar to this compound(4360-63-8)Category: dioxole, numerous studies have shown that this compound(SMILES:BrCC1OCCO1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem