The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Bromomethyl-1,3-dioxolane( cas:4360-63-8 ) is researched.COA of Formula: C4H7BrO2.Wan, Li-Qiang; Cao, Jin-Ge; Niu, Dawen; Zhang, Xia published the article 《Cobalt-Catalyzed Umpolung Alkylation of Imines To Generate α-Branched Aliphatic Amines》 about this compound( cas:4360-63-8 ) in Organic Letters. Keywords: branched aliphatic amine preparation; imine alkyl bromide umpolung alkylation cobalt catalyst. Let’s learn more about this compound (cas:4360-63-8).
A general and mild approach to prepare α-branched aliphatic amines I [R = n-Bu, cyclohexyl, 1,3-dioxolan-2-ylmethyl, etc.; R1 = H, Me; R2 = Me, Ph, 3-furyl, etc.] from imines. This method capitalized on a cobalt-catalyzed umpolung alkylation of imines, employed easily available reaction partners, and demonstrated a broad substrate scope. Mechanistic studies suggested this transformation occurs by a radical pathway.
In addition to the literature in the link below, there is a lot of literature about this compound(2-Bromomethyl-1,3-dioxolane)COA of Formula: C4H7BrO2, illustrating the importance and wide applicability of this compound(4360-63-8).
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem