So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Knight, Brian J.; Tolchin, Zachary A.; Smith, Joel M. researched the compound: Methyl 5-fluoro-3-pyridinecarboxylate( cas:455-70-9 ).Related Products of 455-70-9.They published the article 《A predictive model for additions to N-alkyl pyridiniums》 about this compound( cas:455-70-9 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: pyridine Grignard methyl triflate regioselective dearomative addition; dihydropyridine preparation. We’ll tell you more about this compound (cas:455-70-9).
Disclosed in this communication is a thorough study on the dearomative addition of organomagnesium nucleophiles to N-alkyl pyridinium electrophiles. The regiochem. outcomes have observable and predictable trends associated with the substituent patterns on the pyridinium electrophile. Often, the substituent effects can be either additive, giving high selectivities, or ablative, giving competing outcomes. Addnl., the nature of the organometallic nucleophilic component was also investigated for its role in the regioselective outcome. The effects of either reactive component are important to both the overall reactivity and site of nucleophilic addition The utility of these observed trends is demonstrated in a concise, dearomative synthesis of a tricyclic compound shown to have insecticidal activity.
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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem