The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Research and development of phospha sugar anti-cancer agents with anti-leukemic activity, the main research direction is phenylphospholene phospha sugar analog preparation antileukemic activity.Name: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide.
We have synthesized three deoxybromophospha sugar analogs, 4-bromo-3-methyl-1-phenyl-2-phospholene 1-oxide (MBMPP (2)), 2,3-dibromo-3-methyl-1-phenylphospholane 1-oxide (DBMPP (3)), the 2,3,4-tribromo-3-methyl-1-phenylphospholane 1-oxide (TBMPP (4)), by the reaction of 3-methyl-1-phenyl-2-phospholene 1-oxide (1b) and/or 2 with bromine, and investigated their potentials as anti-leukemic agents against human leukemia cell lines of K562 and U937. Cells’ growth inhibition was determined by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) in vitro assay. All agents showed inhibitory effects on leukemia cell proliferation, indicating that inhibition appeared to be dependent on number of bromine substituent in the heterocyclic structure. Further, the phospha sugar derivatives did not show any inhibitory effects on normal cell proliferation. These agents may facilitate the development of new strategies in mol. targeting anti-leukemic therapy.
From this literature《Research and development of phospha sugar anti-cancer agents with anti-leukemic activity》,we know some information about this compound(707-61-9)Name: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, but this is not all information, there are many literatures related to this compound(707-61-9).
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem