Recommanded Product: 22353-34-0. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-Chloropyridin-3-amine, is researched, Molecular C5H5ClN2, CAS is 22353-34-0, about Boric Acid Catalyzed Direct Amidation between Amino-Azaarenes and Carboxylic Acids. Author is Yun, Fan; Cheng, Chunhui; Zhang, Jing; Li, Jingxuan; Liu, Xia; Xie, Rui; Tang, Pingwah; Yuan, Qipeng.
A novel and facile boric acid-catalyzed direct amidation between amino-azaarene compounds and carboxylic acids was developed. The amidation proceeded cleanly and provided good to excellent yields of the desired amides. Boric acid is a green and inexpensive catalyst. It was also found that N,N,N’,N’-tetramethylpropane-1,3-diamine acted as an additive accelerating this boric acid-catalyzed amidation. A mixed acid anhydride was postulated to be the active intermediate responsible for this successful amidation. This direct amidation was an atom- and step-economical reaction.
If you want to learn more about this compound(5-Chloropyridin-3-amine)Recommanded Product: 22353-34-0, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(22353-34-0).
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem