Chemoenzymatic Synthesis of δ-Keto β-Hydroxy Esters as Useful Intermediates for Preparing Statins was written by Tartaggia, Stefano;Fogal, Stefano;Motterle, Riccardo;Ferrari, Clark;Pontini, Marta;Aureli, Roberto;De Lucchi, Ottorino. And the article was included in European Journal of Organic Chemistry in 2016.Category: dioxole The following contents are mentioned in the article:
Enantiopure (R)-3-hydroxy-5-oxohexanoic acid esters have proven to be useful intermediates in the synthesis of the side chain of statins, in view of the recently described preparation of rosuvastatin and other statins through aldol reactions. Herein, an improved synthesis of these intermediates, by combining chem. and enzymic reactions, is described. In particular, the selective reduction of a δ-ketal β-keto ester was identified as a key step to obtain derivatives with satisfactory optical purities for use in the synthesis of statins. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Category: dioxole).
Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Category: dioxole
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem