Takahashi, Masashi published the artcileAtropisomeric lactam chemistry: catalytic enantioselective synthesis, application to asymmetric enolate chemistry and synthesis of key intermediates for NET inhibitors, HPLC of Formula: 503538-69-0, the publication is Tetrahedron (2010), 66(1), 288-296, database is CAplus.
In the presence of an (R)-SEGPHOS and Pd(OAc)2 catalyst system, the intramol. N-arylation of ortho-tert-butyl-NH-anilides possessing an iodophenyl group, e.g., I, proceeded in a highly enantioselective manner (89-98% ee) to give optically active atropisomeric lactams, e.g., II, having an N-C chiral axis. MPLC purification of the enantio-enriched lactam products using an achiral silica gel column led to a further increase in the enantiomeric purity (>99% ee). The reaction of the lithium enolate prepared from the optically active atropisomeric lactam with various alkyl halides gave α-substituted and α,α-disubstituted lactam products with high diastereoselectivity. α-Alkylated lactam derivatives were efficiently converted to key intermediates for the synthesis of a norepinephrine transporter inhibitor.
Tetrahedron published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C6H12N2O, HPLC of Formula: 503538-69-0.
Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem