1,2,4-Benzothiadiazine derivatives as α1 and 5-HT1A receptor ligands was written by Tait, Annalisa;Luppi, Amedeo;Franchini, Silvia;Preziosi, Elisa;Parenti, Carlo;Buccioni, Michela;Marucci, Gabriella;Leonardi, Amedeo;Poggesi, Elena;Brasili, Livio. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Reference of 4360-63-8 This article mentions the following:
A series of 1,2,4-benzothiadiazine derivatives I (R = H, Me, Cl) and II with an arylpiperazine moiety linked at position 3 of the heterocyclic ring were synthesized and assessed for their pharmacol. profiles at α1-adrenoceptor subtypes (α1A, α1B and α1D) by functional experiments and by in vitro binding studies at human cloned 5-HT1A receptor. I (R = H) was identified as a α1D antagonist (pKbα1D = 7.59; α1D/α1A > 389; α1D/α1B = 135) with high selectivity over 5-HT1A receptor (5-HT1A/α1D < 0.01), while II (R = Cl) was characterized as a 5-HT1A receptor ligand, highly selective over α1D-adrenoceptor subtype (pKi5-HT1A = 8.04; 5-HT1A/α1D = 1096). Further pharmacol. studies demonstrated that II (R = Cl) was a partial agonist at 5-HT1A receptor (Emax = 23, pD2 = 6.92). In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Reference of 4360-63-8).
2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 4360-63-8
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem