Tag: M.W=250-300

Islam, Tofazzal Md. published the artcileDynamic rearrangement of F-actin organization triggered by host-specific plant signal is linked to morphogenesis of Aphanomyces cochlioides zoospores, COA of Formula: C16H10O5, the publication is Cell Motility and the Cytoskeleton (2008), 65(7), 553-562, database is CAplus and MEDLINE.

Cochliophilin A (5-hydroxy-6,7-methylenedioxyflavone), a root releasing host-specific plant signal triggers chemotaxis and subsequent morphol. changes in pathogenic Aphanomyces cochlioides zoospores before host penetration. The present study illustrates time-course changing patterns of cytoskeletal filamentous actin (F-actin) organization in the zoospores of A. cochlioides during rapid morphol. changes (encystment and germination) after exposure to cochliophilin A. Confocal laser scanning microscopic anal. revealed that F-actin microfilaments remained concentrated at ventral groove and diffusely distributed in peripheral cytoplasm of the zoospore. These microfilaments dramatically rearranged and changed into granular F-actin plaques interconnected with fine arrays during encystment. A large patch of actin arrays accumulated at one pole of the cystospores just before germination. Then the actin plaques moved to the emerging germ tube where a distinct cap of microfilaments was seen at the tip of the emerging hypha. Zoospores treated with an inhibitor of F-actin polymerization, latrunculin B or motility halting and regeneration inducing compound nicotinamide, displayed different patterns of F-actin in both zoospores and cystospores than those obtained by the induction of cochliophilin A. Collectively, these results indicate that the host-specific plant signal cochliophilin A triggers a dynamic polymerization/depolymerization of F-actin in pathogenic A. cochlioides zoospores during early events of plant-peronosporomycete interactions.

Cell Motility and the Cytoskeleton published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, COA of Formula: C16H10O5.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Islam, M. Tofazzal published the artcileVariation in chemotactic preferences of Aphanomyces cochlioides zoospores to flavonoids, Application In Synthesis of 110204-45-0, the publication is Zeitschrift fuer Naturforschung, C: Journal of Biosciences (2009), 64(11/12), 847-852, database is CAplus and MEDLINE.

The zoospores of the phytopathogenic Aphanomyces cochlioides are chemotactically attracted by a host-specific flavone, cochliophilin A (5-hydroxy-6,7-methylenedioxyflavone), and repelled from the mammalian estrogens or estrogenic compounds This study further examined the responses of A. cochlioides zoospores to some flavonoids structurally related to cochliophilin A or compounds known as phytoestrogens. The bioassay revealed that some synthetic flavones (such as 6-methyl-4′-methoxyflavone, 3-hydroxy-4′-methoxyflavone, 7-hydroxy-5-methylflavone, 3-hydroxy-4′-methoxy-6-methylflavone) elicited attractant activity at concentrations as low as picomolar (10 pM), which was an 100-fold lower concentration than that of the threshold concentration of the host-specific attractant cochliophilin A. Apparently, a hydrophobic B-ring with an alkylated (methylated) A-ring or a methoxylated B-ring with an unsubstituted A-ring in the flavone skeleton played a significant role in higher attractant activity. On the other hand, all known estrogenic flavonoids (such as equol, 3′- or 8-prenylated naringenins) displayed potent repellent activity toward zoospores. Surprisingly, zoospores were attracted by non-estrogenic 6-prenylated naringenin indicating that repellent activity is linked to the estrogenic activity of the phytoestrogens.

Zeitschrift fuer Naturforschung, C: Journal of Biosciences published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, Application In Synthesis of 110204-45-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Zhang, Wei published the artcileChemical constituents of Kochia scoparia, Related Products of dioxole, the publication is Zhongyaocai (2013), 36(6), 921-924, database is CAplus.

The chem. constituents of Kochia scoparia were investigated. The constituents of EtOAc-soluble portion were isolated and purified by silica gel column chromatog. Their structures were identified by spectral features. Twelve compounds were isolated and identified as tectorigenin (1), pratensein (2), 5,2′-dihydroxy-6,7-methylenedioxyisoflavone (3), iriflogenin (4), 5-hydroxy-6,7-methylenedioxyflavone (5), ferulic acid (6), N-trans-feruloylmethoxytyramine (7), N-trans-feruloyltyramine (8), stigmasterol (9), oleanolic acid (10), β-stigmasterol (11) and daucosterol (12). Compounds 1-9 are isolated from this plant for the first time.

Zhongyaocai published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C28H41N2P, Related Products of dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Ma, Xiao-Pan published the artcileNovel flavones from the root of Phytolacca acinosa ROXB., Safety of 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, the publication is Chemistry & Biodiversity (2017), 14(12), n/a, database is CAplus and MEDLINE.

Two new flavones, 6,7-methylenedioxy-4-hydroxypeltogynan-7′-one (1), cochliophilin B (2), as well as 2 known ones, cochliophilin A (3) and 6-methoxy-7-hydroxyflavone (4), were isolated from the ethanol extract of the root of P. acinosa ROXB. Compound 1 was a flavanol framework with one δ-lactone unit, which is rather rare in Nature. The structures of the new compounds were determined on the basis of extensive spectroscopic (IR, MS, and 1D- and 2D-NMR) analyses; the absolute configuration of 1 was established by comparing exptl. and calculated electronic CD spectra. The structures of the known compounds were fixed by comparison with literature data. Compounds 2 and 4 showed modest inhibitory activities against the BEL-7402 cell line, with IC₅₀ values of 28.22 and 39.16 μM, resp.

Chemistry & Biodiversity published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, Safety of 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Deng, Lan published the artcileA novel synthesis method of baicalein derivatives and their bronchodilation activity, SDS of cas: 110204-45-0, the publication is Zhongguo Yaoke Daxue Xuebao (2010), 41(5), 414-418, database is CAplus.

Ten baicalein derivatives with bronchodilation activity were selectively synthesized using baicalin as a starting material and applying its glucosyl group as a protecting group. Their structures were confirmed by IR, MS, and ¹H NMR data. The preliminary biol. assay results showed that the baicalein derivatives could inhibit contraction of tracheal smooth muscle induced by acetylcholine (Ach), KCl, and histamine (His) in guinea pig. This finding indicates a potential application of baicalein derivatives in chronic obstructive pulmonary diseases (COPD).

Zhongguo Yaoke Daxue Xuebao published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, SDS of cas: 110204-45-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Lee, Yashang published the artcileIncreased Anti-P-glycoprotein Activity of Baicalein by Alkylation on the A Ring, Recommanded Product: 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, the publication is Journal of Medicinal Chemistry (2004), 47(22), 5555-5566, database is CAplus and MEDLINE.

The aqueous extract of Scutellariae baicalensis Georgi has inhibitory activity against P-gp 170, a multiple drug resistant gene product. Baicalein, one of the major flavones, was found to be responsible for this activity. The hydroxyl groups of the A ring of baicalein were systematically alkylated in order to assess the effect of such modifications on the activity against P-gp 170. The impact of the baicalein modifications on activity against the growth of a human nasopharyngeal cancer cell line KB and its P-gp 170 overexpressing cell line KB/MDR were also examined The results indicate that alkylation of R5 of baicalein does not have a major impact on the interaction with P-gp 170, whereas alkylation of R6 or R7 alone or both, could enhance the interaction of baicalein with P-gp 170 as well as the amount of intracellular accumulation of vinblastine, a surrogate marker for the activity of P-gp 170 pump of KB/MDR cells. In this case, the optimal linear alkyl functionality is a Pr side chain. These modifications could also alter the activity of compounds inhibiting cell growth. Among the different compounds synthesized, the most potent mol. against P-gp 170 is 5-methoxy-6,7-dipropyloxyflavone. Its inhibitory activity against P-gp 170 is approx. 40 times better, based on EC₅₀ (concentration of the compound enhancing 50% of the intracellular vinblastine accumulation in the KB/MDR cells) and 3 times higher, based on A_max (the intracellular vinblastine accumulation of the KB/MDR cells caused by the compound) as compared to baicalein. One compound is also a more selective inhibitor than baicalein against P-gp 170, because its cytotoxicity is less than that observed for baicalein. The growth inhibitory IC₅₀ of the compound against KB and KB/MDR cells are about the same, suggesting that compound 23 is unlikely to be a substrate of P-gp 170 pump. Acetylation of R6, R7 or both could also decrease EC₅₀ and increase A_max. Acetylated compounds are more toxic than baicalein, and their potency against cell growth is compromised by the presence of P-gp 170, suggesting that these compounds are substrates of P-gp 170. Benzylation of R6 or R7 but not both also enhanced anti-P-gp170 activity and potency against cell growth; however, the presence of P-gp 170 in cells did not have an impact on their sensitivity to these mols., suggesting that the benzylated compounds are inhibitors but not substrates of P-gp 170, and perhaps have a different mechanism of action. In conclusion, the substitutions of R6 and R7 hydroxyl groups by alkoxy groups, acetoxy groups, or benzyloxy groups could yield compounds with different modes of action against P-gp 170 with different mechanisms of action against cell growth.

Journal of Medicinal Chemistry published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, Recommanded Product: 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Liu, Pan published the artcilePhenylalanine Metabolism Is Dysregulated in Human Hippocampus with Alzheimer′s Disease Related Pathological Changes, COA of Formula: C16H10O5, the publication is Journal of Alzheimer’s Disease (2021), 83(2), 609-622, database is CAplus and MEDLINE.

Alzheimer′s disease (AD) is one of the most challenging diseases causing an increasing burden worldwide. Although the neuropathol. diagnosis of AD has been established for many years, the metabolic changes in neuropathol. diagnosed AD samples have not been fully investigated. To elucidate the potential metabolism dysregulation in the postmortem human brain samples assessed by AD related pathol. examination We performed untargeted and targeted metabolomics in 44 postmortem human brain tissues. The metabolic differences in the hippocampus between AD group and control (NC) group were compared. The results show that a pervasive metabolic dysregulation including phenylalanine metabolism, valine, leucine, and isoleucine biosynthesis, biotin metabolism, and purine metabolism are associated with AD pathol. Targeted metabolomics reveal that phenylalanine, phenylpyruvic acid, and N-acetyl-L-phenylalanine are upregulated in AD samples. In addition, the enzyme IL-4I1 catalyzing transformation from phenylalanine to phenylpyruvic acid is also upregulated in AD samples. There is a pervasive metabolic dysregulation in hippocampus with AD-related pathol. changes. Our study suggests that the dysregulation of phenylalanine metabolism in hippocampus may be an important pathogenesis for AD pathol. formation.

Journal of Alzheimer’s Disease published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, COA of Formula: C16H10O5.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Sakihama, Yasuko published the artcileA photoaffinity probe designed for host-specific signal flavonoid receptors in phytopathogenic Peronosporomycete zoospores of Aphanomyces cochlioides, Related Products of dioxole, the publication is Archives of Biochemistry and Biophysics (2004), 432(2), 145-151, database is CAplus and MEDLINE.

Aphanomyces cochlioides zoospores show chemotaxis to cochliophilin A (5-hydroxy-6,7-methylenedioxyflavone, 1), a host derived attractant, and also respond to 5,7-dihydroxyflavone (2) known as an equivalent chemoattractant. To investigate the chemotactic receptors in the zoospores, we designed photoaffinity probes 4′-azido-5,7-dihydroxyflavone (3) and 4′-azido-7-O-biotinyl-5-hydroxyflavone (4) considering chem. structure of 2. Both 3 and 4 had zoospore attractant activity which was competitive with that of 1. When zoospores were treated with the biotinylated photoaffinity probe followed by UV irradiation and streptavidin-gold or peroxidase-conjugated streptavidin, probe-labeled proteins were detected on the cell membrane. This result indicated that the 1-specific-binding proteins, a candidate for hypothetical cochliophilin A receptor, were localized on the cell membrane of the zoospores. This is the first exptl. evidence of flavonoid-binding proteins being present in zoospores, using chem. synthesized azidoflavone as photoaffinity-labeling reagent.

Archives of Biochemistry and Biophysics published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, Related Products of dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Takahashi, Hajime published the artcileNew flavonoids isolated from infected sugarbeet roots, Application of 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, the publication is Bulletin of the Chemical Society of Japan (1987), 60(6), 2261-2, database is CAplus.

New flavonoid compounds 3,5-dihydroxy-6,7-methylenedioxyflavanone, 2′,5-dihydroxy-6,7-methylenedioxyisoflavone, and 5-hydroxy-6,7-methylenedioxyflavone were isolated from sugar beet roots infected with Rhizoctonia solani.

Bulletin of the Chemical Society of Japan published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C24H12, Application of 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Fernando, Ganwarige Sumali N. published the artcileApplication of an Ultrasound-Assisted Extraction Method to Recover Betalains and Polyphenols from Red Beetroot Waste, Quality Control of 110204-45-0, the publication is ACS Sustainable Chemistry & Engineering (2021), 9(26), 8736-8747, database is CAplus.

Agriculture and food industries generate substantial quantities of waste material with a huge potential for bioactive ingredients to be recovered and converted into high-value chems. Red beetroot, known for its high content in betalains, natural red pigments, as well as polyphenols, fiber, and nitrate, is experiencing increasing demand, in particular as juice, which is leaving behind large amounts of waste. The present study focused on the recovery of betalains and polyphenols from dried whole beetroot and wet and dried beet pulp waste from the juicing industry. As part of an ultrasound-assisted extraction, ethanol/water-based solvent mixtures were used as they were found to be more effective than single solvents. Enzyme-assisted extraction was initially examined in the case of wet pulp but was not able to retain betalains. Betalains appear to be more stable in dried pulp. Ultrasound-assisted extraction was found to be more suitable to effectively extract both betalains and polyphenols with a high bioactive yield from dried pulp. The total betalain and polyphenol profiles as well as storage stability and antioxidant capacities were evaluated over a period of four weeks after extraction from the dried waste. During the four-week storage, betalains quickly degraded at room temperature in contrast to -20°C, whereas polyphenols and antioxidative activity were much less influenced by temperature When compared, dried samples from the beetroot juicing industry demonstrate good betalain and polyphenol extractability; thus, these data indicate that dried beet waste can serve as a good source of betalains for the color industry and other technol. sectors.

ACS Sustainable Chemistry & Engineering published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, Quality Control of 110204-45-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem