Tag: M.W:100-200

Klyba, L. V.; Nedolya, N. A.; Sanzheeva, E. R.; Tarasova, O. A. published the article 《Mass Spectra of New Heterocycles: XXIII. Electron Impact and Chemical Ionization Study of 5-[(Cyanomethyl)sulfanyl]- and 5-[(1,3-Dioxolan-2-ylmethyl)sulfanyl]-1H-pyrrol-2-amines》. Keywords: cyanomethyl sulfanyl dioxolanylmethyl pyrrolamine preparation.They researched the compound: 2-Bromomethyl-1,3-dioxolane( cas:4360-63-8 ).Quality Control of 2-Bromomethyl-1,3-dioxolane. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4360-63-8) here.

The fragmentation of pyrroles I [R1 = R2 = Me, Et, n-Pr; R3 = Me, s-Bu, c-hexyl, etc.; -R1R2- = -(CH2)4-, -(CH2)5-, -(CH2)2O(CH2)2; R4 = CN, 1,3-dioxolan-2-yl] under electron impact (70 eV) and chem. ionization with methane as reactant gas has been studied for the first time. Electron impact ionization of 5-[(cyanomethyl)sulfanyl]-substituted pyrroles generates low-stability mol. ions {M+., Irel 4-22%; compared to Irel 16-69% for 5-[(1,3-dioxolan-2-ylmethyl)sulfanyl] analogs} whose primary fragmentation involves cleavage of the C-S bond with expulsion of NCCH2 radical. Other fragmentation pathways of the mol. ions include formation of [M – CHR4]+. ions (R4 = CN) and substituent decomposition products. The mass spectra of 5-[(1,3-dioxolan-2-ylmethyl)sulfanyl]pyrroles characteristically show [M – SCH2R4]+ ion peak. The most intense ion peaks in the chem. ionization mass spectra of 5-[(cyanomethyl)sulfanyl] derivatives are those of M+. (Irel 18-69%) and [M + H]+ (Irel 34-100%). Both 5-[(cyanomethyl)sulfanyl]- and 5-[(1,3-dioxolan-2-ylmethyl)sulfanyl]pyrroles decompose mainly through cleavage of the CH2-S and C5-S bonds with the formation of stable [M – CH2R4]+ (Irel 92-100%), [M + H – CH2R4]+. (Irel 22-75%), and [M + H – SCH2R4]+. ions (Irel 6-25%).

After consulting a lot of data, we found that this compound(4360-63-8)Quality Control of 2-Bromomethyl-1,3-dioxolane can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Kim, Dae-Kwon; Um, Hyun-Suk; Park, Hoyoon; Kim, Seonwoo; Choi, Jin; Lee, Chulbom published the article 《Silyloxymethanesulfinate as a sulfoxylate equivalent for the modular synthesis of sulfones and sulfonyl derivatives》. Keywords: sulfone preparation; silyloxymethanesulfonate preparation alkyl halide alkylation; aryl halide silyloxymethanesulfonate preparation arylation copper catalyst; sodium tertbutyldimethylsilyloxymethanesulfonate preparation alkyl halide alkylation; tertbutyldimethylsilyloxymethanesulfonate sodium aryl halide arylation preparation copper catalyst.They researched the compound: 2-Bromomethyl-1,3-dioxolane( cas:4360-63-8 ).COA of Formula: C4H7BrO2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4360-63-8) here.

An efficient protocol for the modular synthesis of sulfones and sulfonyl derivatives RS(O)2R1 (R = 3-phenylpropyl, Ph, naphthalen-2-yl, etc.; R1 = [(tert-butyldimethylsilyl)oxy]methyl, 4-(morpholin-4-yl)phenyl, hex-5-yn-1-yl, etc.) has been developed utilizing sodium tert-butyldimethylsilyloxymethanesulfinate (TBSOMS-Na) as a sulfoxylate (SO22-) equivalent TBSOMS-Na, easily prepared from the com. reagents Rongalite and TBSCl, serves as a potent nucleophile in S-alkylation and Cu-catalyzed S-arylation reactions with alkyl and aryl electrophiles R1X (X = I, Br). The sulfone products thus obtained can undergo the second bond formation at the sulfur center with various electrophiles without a sep. unmasking step to afford sulfones and sulfonyl derivatives such as sulfonamides and sulfonyl fluorides.

After consulting a lot of data, we found that this compound(4360-63-8)COA of Formula: C4H7BrO2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Product Details of 22353-34-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-Chloropyridin-3-amine, is researched, Molecular C5H5ClN2, CAS is 22353-34-0, about Pyridyl-urea catalysts for the solvent-free ring-opening polymerization of lactones and trimethylene carbonate.

The ring-opening polymerization (ROP) of lactones is an effective method for the preparation of biocompatible and biodegradable aliphatic polyesters, for which the development of efficient organocatalysts with high activity and good controllability is highly desirable. A series of novel pyridyl-urea catalysts was synthesized and applied in the solvent-free ROP of lactones and trimethylene carbonate. Combined with 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene (MTBD), the pyridyl-urea/MTBD systems showed a fast and living/controlled behavior in the ROP, generating polymers with narrow mol. weight distributions. The influences of catalyst structure, type of base, pyridyl-urea/base ratio, feed ratio of monomer/initiator and reaction temperature on the catalytic properties were investigated. A possible mechanism was proposed on the basis of NMR titration and dilution experiments

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

HPLC of Formula: 707-61-9. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Intermolecular Reductive C-N Cross Coupling of Nitroarenes and Boronic Acids by PIII/PV=O Catalysis. Author is Nykaza, Trevor V.; Cooper, Julian C.; Li, Gen; Mahieu, Nolwenn; Ramirez, Antonio; Luzung, Michael R.; Radosevich, Alexander T..

A main group-catalyzed method for the synthesis of aryl- and heteroarylamines by intermol. C-N coupling is reported. The method employs a small-ring organophosphorus-based catalyst (1,2,2,3,4,4-hexamethylphosphetane) and a terminal hydrosilane reductant (phenylsilane) to drive reductive intermol. coupling of nitro(hetero)arenes with boronic acids. Applications to the construction of both Csp2-N (from arylboronic acids) and Csp3-N bonds (from alkylboronic acids) are demonstrated; the reaction is stereospecific with respect to Csp3-N bond formation. The method constitutes a new route from readily available building blocks to valuable nitrogen-containing products with complementarity in both scope and chemoselectivity to existing catalytic C-N coupling methods.

After consulting a lot of data, we found that this compound(707-61-9)HPLC of Formula: 707-61-9 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Carlson, Lars A.; Hedbom, Christina; Helgstrand, Erik; Sjoberg, Berndt; Stjernstrom, Nils E. published the article 《Potential hypolipidemic agents. III. Heterocyclic compounds affecting free fatty acid mobilization in vivo》. Keywords: fatty acid mobilization fluoronicotinate blood; fluoropyridylacetate fatty acid mobilization blood; methylpyrazole fatty acid mobilization blood.They researched the compound: Methyl 5-fluoro-3-pyridinecarboxylate( cas:455-70-9 ).Recommanded Product: Methyl 5-fluoro-3-pyridinecarboxylate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:455-70-9) here.

Compounds such as 3-methyl-5-isoxazolecarboxylic acid [4857-42-5], 5-fluoronicotinic acid [402-66-4], 5-fluoro-3-pyridylacetic acid [38129-24-7], and 3-methylpyrazole [1453-58-3] exhibited the highest inhibition of free fatty acid mobilization in blood among 188 heterocyclic compounds tested in dogs, while compounds such as 5-methyl-3-isoxazolecarboxylic acid [3405-77-4], 2-fluoronicotinic acid [393-55-5], and 3-aminobenzoic acid [99-05-8] had no effect on free fatty acid mobilization.

After consulting a lot of data, we found that this compound(455-70-9)Recommanded Product: Methyl 5-fluoro-3-pyridinecarboxylate can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Preparation of phospho sugar analogs and their evaluation as novel anticancer agents, the main research direction is phospho sugar analog preparation anticancer leukemia.Related Products of 707-61-9.

Phospho sugars were prepared by a novel synthetic route starting from phosphorus heterocyclic compounds, 2-phospholenes. The anhydro- and deoxy-phospha sugar derivatives have been revealed to have potential anticancer activities against human leukemia K562 and U937 cell lines. In this article, deoxybromophospho sugars with different numbers of bromo substituents were prepared, and their anticancer activities were evaluated by MTT method. The order of the activities depending on the number of bromo substituent was first revealed, and trideoxytribromotetrofuranose type phospho sugar [2,3,4-tribromo-3-methyl-1-phenylphospholane 1-oxide (4: TBMPPAO)] was the most active among these phospha sugars prepared Diastereomers of dideoxydibromotetrofuranose-type phospho sugar [2,3-dibromo-3-methyl-1-phenylphospholane 1-oxide (2: DBMPPAO)] were separated into four components, and the structure as well as the character of each component was assigned by spectral and chromatog. data as well as by MTT method.The deoxybromophospha sugars have higher antileukemia activity than Gleevec against U937 cells.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Inhibition of bacteria by 5-fluoronicotinic acid and other analogs of nicotinic acid》. Authors are Streigbtoff, Frank.The article about the compound:Methyl 5-fluoro-3-pyridinecarboxylatecas:455-70-9,SMILESS:COC(=O)C1=CC(F)=CN=C1).Synthetic Route of C7H6FNO2. Through the article, more information about this compound (cas:455-70-9) is conveyed.

Several compounds related to 5-fluoronicotinic acid (I) have been demonstrated to inhibit Streptococcus spp. (Viridans group), Staphylococcus aureus, Escherichia coli, and Lactobacillus plan- tarum. The most active compounds were I and 5-fluoronicotin- amide (II). The growth of Streptococcus spp. was inhibited more than 5% by 0.05 γ/ml. of I or 0.5 of II. The inhibition of Streptococcus from 1 part of I or II was reversed by 4 and 2 parts of nicotinic acid, resp. The inhibition of E. coli from 100 parts of I or II was reversed by I part of nicotinic acid. Inhibitions by most other active compounds could be reversed by nicotinic acid. In experiments with mice, 8 compounds related to I had activity against Streptococcus pyogenes; I, II, and 5-fluoro-N-dimethyl- aminomethylnicotinamide protected all mice at 83 mg./kg. The action of 200 mg./kg. I was reversed by 20 mg./kg. of nicotinic acid. The activity of I was not increased by modifica- tions at the number 3 or 5 positions on the pyridine ring or by any other structural changes.

Although many compounds look similar to this compound(455-70-9)Synthetic Route of C7H6FNO2, numerous studies have shown that this compound(SMILES:COC(=O)C1=CC(F)=CN=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Safety of 2-Bromomethyl-1,3-dioxolane. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about Mass Spectra of New Heterocycles: XXIII. Electron Impact and Chemical Ionization Study of 5-[(Cyanomethyl)sulfanyl]- and 5-[(1,3-Dioxolan-2-ylmethyl)sulfanyl]-1H-pyrrol-2-amines. Author is Klyba, L. V.; Nedolya, N. A.; Sanzheeva, E. R.; Tarasova, O. A..

The fragmentation of pyrroles I [R1 = R2 = Me, Et, n-Pr; R3 = Me, s-Bu, c-hexyl, etc.; -R1R2- = -(CH2)4-, -(CH2)5-, -(CH2)2O(CH2)2; R4 = CN, 1,3-dioxolan-2-yl] under electron impact (70 eV) and chem. ionization with methane as reactant gas has been studied for the first time. Electron impact ionization of 5-[(cyanomethyl)sulfanyl]-substituted pyrroles generates low-stability mol. ions {M+., Irel 4-22%; compared to Irel 16-69% for 5-[(1,3-dioxolan-2-ylmethyl)sulfanyl] analogs} whose primary fragmentation involves cleavage of the C-S bond with expulsion of NCCH2 radical. Other fragmentation pathways of the mol. ions include formation of [M – CHR4]+. ions (R4 = CN) and substituent decomposition products. The mass spectra of 5-[(1,3-dioxolan-2-ylmethyl)sulfanyl]pyrroles characteristically show [M – SCH2R4]+ ion peak. The most intense ion peaks in the chem. ionization mass spectra of 5-[(cyanomethyl)sulfanyl] derivatives are those of M+. (Irel 18-69%) and [M + H]+ (Irel 34-100%). Both 5-[(cyanomethyl)sulfanyl]- and 5-[(1,3-dioxolan-2-ylmethyl)sulfanyl]pyrroles decompose mainly through cleavage of the CH2-S and C5-S bonds with the formation of stable [M – CH2R4]+ (Irel 92-100%), [M + H – CH2R4]+. (Irel 22-75%), and [M + H – SCH2R4]+. ions (Irel 6-25%).

Although many compounds look similar to this compound(4360-63-8)Safety of 2-Bromomethyl-1,3-dioxolane, numerous studies have shown that this compound(SMILES:BrCC1OCCO1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Related Products of 707-61-9. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Biphilic Organophosphorus-Catalyzed Intramolecular Csp2-H Amination: Evidence for a Nitrenoid in Catalytic Cadogan Cyclizations. Author is Nykaza, Trevor V.; Ramirez, Antonio; Harrison, Tyler S.; Luzung, Michael R.; Radosevich, Alexander T..

A small-ring phosphacycloalkane (1,2,2,3,4,4-hexamethylphosphetane) (I) catalyzes intramol. C-N bond forming heterocyclization of o-nitrobiaryls and o-nitrostyrenes in the presence of a hydrosilane terminal reductant. The method provides scalable access to diverse carbazole and indole compounds under operationally trivial homogeneous organocatalytic conditions, as demonstrated by 17 examples conducted on 1 g scale. In situ NMR reaction monitoring studies support a mechanism involving catalytic PIII/PV=O cycling, where tricoordinate phosphorus compound I represents the catalytic resting state. For the catalytic conversion of o-nitrobiphenyl to carbazole, the kinetic reaction order was determined for phosphetane catalyst I (first order), substrate (first order), and phenylsilane (zeroth order). For differentially 5-substituted 2-nitrobiphenyls, the transformation is accelerated by electron-withdrawing substituents (Hammett factor ρ = +1.5), consistent with the accrual of neg. charge on the nitro substrate in the rate-determining step. DFT modeling of the turnover-limiting deoxygenation event implicates a rate-determining (3 + 1) cheletropic addition between the phosphetane catalyst and 2-nitrobiphenyl substrate to form an unobserved pentacoordinate spiro-bicyclic dioxazaphosphetane, which decomposes via (2 + 2) cycloreversion giving 1 equiv of phosphetane P-oxide and 2-nitrosobiphenyl. Exptl. and computational investigations into the C-N bond forming event suggest the involvement of an oxazaphosphirane (2 + 1) adduct between I and 2-nitrosobiphenyl, which evolves through loss of phosphetane P-oxide to give the observed carbazole product via C-H insertion in a nitrene-like fashion.

Although many compounds look similar to this compound(707-61-9)Related Products of 707-61-9, numerous studies have shown that this compound(SMILES:CC1=CP(CC1)(C2=CC=CC=C2)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Name: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Synthesis of novel deoxy λ5 phospha sugar nucleosides: 1,3-dipolar cycloaddition of an azidophospholane with alkynes.

Several novel phospha sugar nucleosides, analogs of normal sugar nucleosides, were synthesized from a phospholene 1-oxide derivative Bromination of a phospholene precursor in aqueous organic medium gave regio diastereomers, the threo and erythro bromohydrins (1-bromo-1,3,4-trideoxy-1,4-C-[(R,S)-phenylphosphinylidene]-glycero-tetrofuranose). Further substitution of the threo isomer with sodium azide led to its corresponding azidophospholane (1-azido-1,3,4-trideoxy-2-methyl-1,4-C-[(R)-phenylphosphinylidene]-β-D-glycero-tetrofuranose) (I). 1,3-Dipolar cycloaddition of I with various electron-deficient and electron-rich alkynes afforded triazole derivatives that are nucleoside analogs. The strong electron-withdrawing phosphoryl group in the hemiacetal ring exerted no effect over reaction regioselectivity of the 1,3-dipolar cycloaddition, but steric effects of the alkynes played a vital role on the selectivity, since the regioisomer ratios and the rates and yields of cycloadducts changed as the bulkiness of the substituents on the acetylene changes. Structures of all compounds were unequivocally confirmed by 1H, 13C, and 31P NMR and mass spectral studies. Single crystal X-ray crystallog. anal. of some derivatives allowed determination of configuration of the phospha sugar nucleosides.

Although many compounds look similar to this compound(707-61-9)Name: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, numerous studies have shown that this compound(SMILES:CC1=CP(CC1)(C2=CC=CC=C2)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem