Tag: M.W:100-200

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Synthesis of some 1-aryl-2,3-dibromophospholanes as novel anti-cancer agents.Related Products of 707-61-9.

Novel phosphorus heterocyclic compounds, 3-methyl-1-(3-bromophenyl as well as some 3-substituted phenyl)-2-phospholene 1-oxides, were synthesized from 1-phenyl-2-phospholene 1-oxide via 3-methyl-1-(3-nitrophenyl)-2-phospholene 1-oxide. 1-(4-Bromophenyl)-2-phospholene was prepared by Grignard coupling reaction of 1-chloro-3-methyl-2-phospholene 1-oxide with 4-bromophenylmagnesium bromide. 2,3-Dibromo-3-methyl-1-arylphospholane 1-oxides were prepared by the addition reaction of bromine to the C=C double bond of 2-phospholenes. The substituent effect of the Ph group of the 1-aryl-phospholanes on the observed anti-proliferative effect against U937 leukemia cell lines evaluated by MTT in vitro methods showed that 2,3-dibromo-3-methyl-1-(4-bromophenyl)phospholane was the most active among 1-arylphospholanes. These novel dibromophosphorus heterocyclic derivatives exhibit much higher anticancer activity than Gleevec (mol. targeting chemotherapeutic agent) against U937 cells.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called N-Oxides of nicotinic acid and its esters, published in 1949, which mentions a compound: 455-70-9, Name is Methyl 5-fluoro-3-pyridinecarboxylate, Molecular C7H6FNO2, Application In Synthesis of Methyl 5-fluoro-3-pyridinecarboxylate.

Nicotinic acid (I) (1 part) in 3 parts glacial AcOH and 3 parts H2O2, heated 3 hrs. on the water bath, gives 70-80% of the N-oxide (II), pale yellow, m. 249° (decomposition); impure II, heated at 100°, decompose spontaneously. II (1 g.) in 20 ml. MeOH, saturated with HCl at 0° and refluxed 2 hrs., gives 0.5 g. of the Me ester, m. 97°; Et ester (III), m. 99.5°. The Et ester of I (2 g.), 10 ml. AcOH, and 30 ml. H2O2, heated 3 hrs. on the water bath, give 1.1 g. III.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about A novel stereocontrolled preparation of phospho sugar derivatives from phospholenes, the main research direction is stereochem oxidation phospholene oxide; furanose phenylphosphinylidene.Related Products of 707-61-9.

Oxidation of 2-phospholene 1-oxides I (R = Ph, R1, R2 = H or Me; R = OMe, R1 = H, R2 = Me) with OsO4-KClO3 in aqueous THF afforded vicinal diols in 35-91% yields. The structure of diol II was established by preparation of its 1,2-di-O-acetyl and 1,2-O-isopropylidene derivatives and by x-ray crystallog. anal.

Compound(707-61-9)Related Products of 707-61-9 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide), if you are interested, you can check out my other related articles.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Reference of 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Synthesis and application of aqueous polycarbodiimide crosslinking agent(I): aqueous cationic polycarbodiimide crosslinking agent. Author is Tong, Rong; Pang, Xiaoyan; Sun, Jing; Ding, Zhiwen; Jia, Jizhang.

Aqueous cationic polycarbodiimide crosslinking agent was synthesized with isophorone diisocyanate (IPDI), polypropylene glycol (PPG400), N,N-dimethylethanolamine (DMEA) and 3-methyl-1-phenyl-2-phosopholene-1-oxide (MPPO) as raw materials. The influences of synthesis conditions such as the dosage of catalyst, reaction time, reaction temperature, nitrogen jet velocity, hydrophilic end-blocking agent, end-blocking temperature and the dosage of end-blocking agent on the blocking reaction were investigated. The developed crosslinking agents were applied to protein finishing agent. And it is found that the properties of obtained finishing film agent are better in the water resistance, alkali resistance, solvent resistance and flexibility. Also, the tensile strength of film increases with a little decrease in brightness and transparency.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Formula: C11H13OP. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about A novel stereocontrolled preparation of phospho sugar derivatives from phospholenes. Author is Yamashita, Mitsuji; Uchimura, Miyuki; Iida, Akihito; Parkanayi, Laszlo; Clardy, Jon.

Oxidation of 2-phospholene 1-oxides I (R = Ph, R1, R2 = H or Me; R = OMe, R1 = H, R2 = Me) with OsO4-KClO3 in aqueous THF afforded vicinal diols in 35-91% yields. The structure of diol II was established by preparation of its 1,2-di-O-acetyl and 1,2-O-isopropylidene derivatives and by x-ray crystallog. anal.

Compound(707-61-9)Formula: C11H13OP received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide), if you are interested, you can check out my other related articles.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Application In Synthesis of Methyl 5-fluoro-3-pyridinecarboxylate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Methyl 5-fluoro-3-pyridinecarboxylate, is researched, Molecular C7H6FNO2, CAS is 455-70-9, about A predictive model for additions to N-alkyl pyridiniums. Author is Knight, Brian J.; Tolchin, Zachary A.; Smith, Joel M..

Disclosed in this communication is a thorough study on the dearomative addition of organomagnesium nucleophiles to N-alkyl pyridinium electrophiles. The regiochem. outcomes have observable and predictable trends associated with the substituent patterns on the pyridinium electrophile. Often, the substituent effects can be either additive, giving high selectivities, or ablative, giving competing outcomes. Addnl., the nature of the organometallic nucleophilic component was also investigated for its role in the regioselective outcome. The effects of either reactive component are important to both the overall reactivity and site of nucleophilic addition The utility of these observed trends is demonstrated in a concise, dearomative synthesis of a tricyclic compound shown to have insecticidal activity.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Formula: C4H7BrO2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about Mass Spectra of New Heterocycles: XXIII. Electron Impact and Chemical Ionization Study of 5-[(Cyanomethyl)sulfanyl]- and 5-[(1,3-Dioxolan-2-ylmethyl)sulfanyl]-1H-pyrrol-2-amines.

The fragmentation of pyrroles I [R1 = R2 = Me, Et, n-Pr; R3 = Me, s-Bu, c-hexyl, etc.; -R1R2- = -(CH2)4-, -(CH2)5-, -(CH2)2O(CH2)2; R4 = CN, 1,3-dioxolan-2-yl] under electron impact (70 eV) and chem. ionization with methane as reactant gas has been studied for the first time. Electron impact ionization of 5-[(cyanomethyl)sulfanyl]-substituted pyrroles generates low-stability mol. ions {M+., Irel 4-22%; compared to Irel 16-69% for 5-[(1,3-dioxolan-2-ylmethyl)sulfanyl] analogs} whose primary fragmentation involves cleavage of the C-S bond with expulsion of NCCH2 radical. Other fragmentation pathways of the mol. ions include formation of [M – CHR4]+. ions (R4 = CN) and substituent decomposition products. The mass spectra of 5-[(1,3-dioxolan-2-ylmethyl)sulfanyl]pyrroles characteristically show [M – SCH2R4]+ ion peak. The most intense ion peaks in the chem. ionization mass spectra of 5-[(cyanomethyl)sulfanyl] derivatives are those of M+. (Irel 18-69%) and [M + H]+ (Irel 34-100%). Both 5-[(cyanomethyl)sulfanyl]- and 5-[(1,3-dioxolan-2-ylmethyl)sulfanyl]pyrroles decompose mainly through cleavage of the CH2-S and C5-S bonds with the formation of stable [M – CH2R4]+ (Irel 92-100%), [M + H – CH2R4]+. (Irel 22-75%), and [M + H – SCH2R4]+. ions (Irel 6-25%).

From this literature《Mass Spectra of New Heterocycles: XXIII. Electron Impact and Chemical Ionization Study of 5-[(Cyanomethyl)sulfanyl]- and 5-[(1,3-Dioxolan-2-ylmethyl)sulfanyl]-1H-pyrrol-2-amines》,we know some information about this compound(4360-63-8)Formula: C4H7BrO2, but this is not all information, there are many literatures related to this compound(4360-63-8).

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthetic Route of C4H7BrO2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about Transition-Metal-Free Deconstructive Lactamization of Piperidines. Author is Romero-Ibanez, Julio; Cruz-Gregorio, Silvano; Sandoval-Lira, Jacinto; Hernandez-Perez, Julio M.; Quintero, Leticia; Sartillo-Piscil, Fernando.

One of the major challenges in organic synthesis is the activation or deconstructive functionalization of unreactive C(sp3)-C(sp3) bonds, which requires using transition or precious metal catalysts. We present here an alternative: the deconstructive lactamization of piperidines without using transition metal catalysts. To this end, we use 3-alkoxyamino-2-piperidones, which were prepared from piperidines through a dual C(sp3)-H oxidation, as transitory intermediates. Exptl. and theor. studies confirm that this unprecedented lactamization occurs in a tandem manner involving an oxidative deamination of 3-alkoxyamino-2-piperidones to 3-keto-2-piperidones, followed by a regioselective Baeyer-Villiger oxidation to give N-carboxyanhydride intermediates, which finally undergo a spontaneous and concerted decarboxylative intramol. translactamization.

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1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 4360-63-8, is researched, SMILESS is BrCC1OCCO1, Molecular C4H7BrO2Journal, RSC Advances called Iron-catalysed allylation-hydrogenation sequences as masked alkyl-alkyl cross-couplings, Author is Bernauer, Josef; Wu, Guojiao; Jacobi von Wangelin, Axel, the main research direction is alkenyl acetate Grignard reagent iron catalyst allylation hydrogenation.HPLC of Formula: 4360-63-8.

An iron-catalyzed allylation of organomagnesium reagents (alkyl, aryl) with simple allyl acetates proceeds under mild conditions (Fe(OAc)2 or Fe(acac)2, Et2O, r.t.) to furnish various alkene and styrene derivatives Mechanistic studies indicate the operation of a homotopic catalyst. The sequential combination of such iron-catalyzed allylation with an iron-catalyzed hydrogenation results in overall C(sp3)-C(sp3)-bond formation that constitutes an attractive alternative to challenging direct cross-coupling protocols with alkyl halides.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 707-61-9, is researched, Molecular C11H13OP, about Catalytic transformation of silicon tetraisocyanate Si(NCO)4 to a polymeric silylcarbodiimide, the main research direction is silylcarbodiimide polymer synthesis silicon tetraisocyanate catalytic transformation; silicon carbide formation silylcarbodiimide polymer degradation.Quality Control of 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide.

A new way for the preparation of inorganic polymeric carbodiimide-based networks is presented which resembles the transformation of mol. isocyanates using 1-phenyl-3-methyl-2-phospholene-1-oxide as a catalyst. The resp. reaction sequence, well established in preparative organic chem., has been applied for the synthesis of carbodiimide-based SiNC(O) materials. Starting from Si(NCO)4 (silicon tetraisocyanate), a transformation to an insoluble extended inorganic array was achieved in boiling dodecane (T = 216 °C). Anal. of the polymer using X-ray diffraction, FT-IR, d. measurement, matrix-assisted laser desorption/ionization time of flight and TGA revealed that this highly moisture-sensitive amorphous network consists of oligomers of high molar mass and exhibits a high d. of around 1.5 g.cm-3, which corresponds quite well to the calculated d. of crystalline Si(NCN)2 reported in the literature. Degradation of this ‘SiNC(O) phase’ with the release of N2 and (CN)2 finally provided SiC as the only crystalline product. No indication of the formation of crystalline Si3N4 or intermediate crystalline ‘SiC2N4’, silicon carbodiimide (= Si(NCN)2), was noticed. Copyright © 2012 John Wiley & Sons, Ltd.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem