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Discovery of 4,5-Dimethyl-1,3-dioxol-2-one

A chemical reaction often occurs in steps, although it may not always be obvious to an observer.

Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.37830-90-3, molecula formula is 4,5-Dimethyl-1,3-dioxol-2-one, below Introduce a new synthetic route., 37830-90-3

Add 50.0 g of 4,5-dimethyl-1,3-dioxol-2-one to a 1 L four-necked flask.530 g of dichloromethane, stirred and dissolved, and heated to reflux, when the internal temperature is not lower than 40 ¡ã C,A mixture of 65 g (1.1 equivalents) of sulfonyl chloride and 132 g of dichloromethane was added dropwise.The internal temperature of the control is not lower than 40 ¡ãC, and the mixture is kept warm for 2 hours after the dropwise addition.The temperature was then raised to 85 ¡ã C while distilling off the dichloromethane. When it reaches 85 ¡ã C, it is rearranged for 2 to 3 hours.At room temperature, crude DMDO-Cl was obtained with a GC purity of 85percent to 90percent.Add 30 ml of isopropanol to the above crude product, stir and cool to -10 ¡ã C ~ -5 ¡ã C,Crystallization 0 ~ 1h, suction filtration, rinse with isopropanol down to -5 ¡ã C,Obtained white crystals 53.3g (yield 81.9percent, GC purity 99.3percent)

A chemical reaction often occurs in steps, although it may not always be obvious to an observer.

Reference£º
Patent; Zhejiang Huahai Pharmaceutical Co., Ltd.; Wang Jiquan; Li Guoxiang; Xiong Xueqiang; (6 pag.)CN103864748; (2019); B;,
1,3-Benzodioxole – Wikipedia
Dioxole | C3H4O2 – PubChem

Extended knowledge of 37830-90-3

A chemical reaction often occurs in steps, although it may not always be obvious to an observer.

Example 17 Preparation of 5-methyl-4-hydroxymethyl-2-oxo-1,3-dioxolene A solution of 4,5-dimethyl-2-oxo-1,3-dioxolene (1 mmol) and selenium dioxide (2.5 mmol) in dioxane was heated at reflux for 1 h. Evaporation, extraction and chromatography gave 5-methyl-4-hydroxymethyl-2-oxo-1,3-dioxolene as a yellow oil. TLC: Rf=0.5, 5percent MeOH-dichloromethane.

A chemical reaction often occurs in steps, although it may not always be obvious to an observer.

Reference£º
Patent; Metabasis Therapeutics, Inc.; US6284748; (2001); B1;,
1,3-Benzodioxole – Wikipedia
Dioxole | C3H4O2 – PubChem

The origin of a common compound about 37830-90-3

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand 4,5-Dimethyl-1,3-dioxol-2-one reaction routes.

37830-90-3, The molecularity is the number of molecules that collide during that step in the mechanism. If only a single reactant molecule in an elementary reaction, that step is designated as unimolecular; if there are two reactant molecules, it is bimolecular.37830-90-3. A new synthetic method of this compound is introduced below.

Step III: 4-Bromomethyl-5-methyl~l,3-dioxol~2-one; A mixture of 4,5-dimethyl-l,3-dioxol-2-one (1.5 g, 0.013158 mol), NBS (2.34 g, 0.013158 mol) and benzoyl peroxide (0.089 g, 0.0003684 mol) in CCl4 (20 mL) was stirred at 77¡ãC for 6 hrs (TLC monitoring: cyclohexane/AcOEt 6:4). The solution was treated with an aqueous solution OfNaHCO3 and extracted with CH2Cl2. The organic phase was dried over Na2SO4 and concentrated under reduced pressure to give 4-bromomethyl-5 -methyl- 1,3- dioxol-2-one (2.34 g). Yield: 92percent.1H-NMR (400 MHz, CDCl3, delta): 2.13 (s, 3H, CH3), 4.18 (s, 2H, CH2Br).

Reference£º
Patent; S.I.M.S. S.r.l. – SOCIETA ITALIANA MEDICINALI SCANDICCI; WO2008/12852; (2008); A1;,
1,3-Benzodioxole – Wikipedia
Dioxole | C3H4O2 – PubChem

The important role of 4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one

The chemical industry reduces the impact on the environment during synthesis, 4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one, , I believe this compound will play a more active role in future production and life.

80841-78-7, The molecularity is the number of molecules that collide during that step in the mechanism. If only a single reactant molecule in an elementary reaction, that step is designated as unimolecular; if there are two reactant molecules, it is bimolecular.80841-78-7. A new synthetic method of this compound is introduced below.

Example 4; The reaction was carried out in the same manner as in Example 1 except that 4- (1-hydroxy-1-methylethyl) -2-propyl-1- {4- [2- (trityltetrazol-5-yl) phenyl] -carboxylic acid sodium salt (Chemical Formula 5) and 50 mL of N, N-dimethylacetamide were added, the temperature was adjusted to 5 to 10 DEG C and 4 g of potassium carbonate was added. A solution of 6.2 g of 4- (chloromethyl) -5-methyl-1,3-dioxol-2-one (Formula 6) in 6 mL of N, N-dimethylacetamide was added dropwise to the reaction portion, For 4 hours. After the reaction was completed, the reaction solution was cooled to 20 to 25 C, and then 220 mL of ethyl acetate, 30 g of salt, and 170 mL of purified water were sequentially added to the reaction mixture, followed by separation of the organic layer, followed by the addition of 30 g of salt and 170 mL of purified water . & Lt; / RTI & gt; 1 g of activated carbon and 20 g of anhydrous sodium sulfate were added to the organic layer, followed by stirring for 30 minutes to 1 hour, followed by filtration. The filtrate was concentrated under reduced pressure, and 100 mL of acetonitrile was added to the residue, followed by stirring at 50 to 55 DEG C for 1 hour. The crystals were cooled to 0 to 5 C., stirred for 2 hours, filtered, washed with 50 mL of isopropyl alcohol and dried to obtain 21.7 g (yield: 93%, purity: 99.96%) of tritylolemethanemethoxysilane

Reference£º
Patent; DONGBANG FTL CO., LTD; Song, Tae Hong; Jung, Hun Suk; Jang, Do Yeon; Moon, Chung Sun; Jung, Hee Jung; (18 pag.)KR101526249; (2015); B1;,
1,3-Benzodioxole – Wikipedia
Dioxole | C3H4O2 – PubChem

Analyzing the synthesis route of 37830-90-3

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products. The stepwise changes are collectively called the reaction mechanism.

An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.4,5-Dimethyl-1,3-dioxol-2-one, cas is 37830-90-3. Here is a downstream synthesis route of the compound 37830-90-3, 37830-90-3

Example 12: (5-Methyl-2-oxo-l,3-dioxol-4-yl)methyl 4-[(4-methoxyphenyl)amino]-6- (methylcarbamoy^quinoline-S-carboxylate. a) Preparation of the intermed 4-bromomethyl-5-methyl-2-oxo-l,3-dioxolene; To a solution of 4,5-dimethyl-l,3-dioxol-2-one (342 mg, 3.0 mmol) in carbon tetrachloride (10 mL) was added azobisisobutyronitrile (AIBN, 9.8 mg, 0.06 mmol) and iV-bromosuccinimide NBS (580 mg, 3.3 mmol). The reaction mixture was heated in the dark in a stem block at 78 C for 20 minutes. The mixture was cooled and evaporated almost into dryness. The mixture was filtered and the residue was evaporated to give a light yellow solid, which contained 20 percent starting material Yield: 450 mg (58percent). The mixture was used in the next step without further purifi- cation., 37830-90-3

Reference£º
Patent; CLANOTECH AB; MALM, Johan; RINGOM, Rune; CALDIROLA, Patrizia; WESTMAN, Jacob; WO2010/133669; (2010); A1;,
1,3-Benzodioxole – Wikipedia
Dioxole | C3H4O2 – PubChem

Some tips on 37830-90-3

The molecularity is the number of molecules that collide during that step in the mechanism. If only a single reactant molecule in an elementary reaction, that step is designated as unimolecular; if there are two reactant molecules, it is bimolecular.37830-90-3. A new synthetic method of this compound is introduced below., 37830-90-3

NBS (19.58 g, 110 mmol) followed by AIBN (0.821 g, 5.00 mmol) were added to a stirred, room temperature mixture of 4,5-dimethyl-l,3-dioxol-2-one (5.70 g, 50 mmol) in benzene (300 mL) and the mixture was stirred at reflux for 1 h. Volatiles were removed.Chromatography over silicaeluting with 5-55% EtOAc/hexane afforded the desired product as a yellow oil.

Reference£º
Patent; NICOX S.A.; MERCK & CO. INC.; ALMIRANTE, Nicoletta; MANDELLI, Valentino; NICOTRA, Alessia; BIONDI, Stefano; ONGINI, Ennio; SEBHAT, Iyassu; WO2010/15447; (2010); A1;,
1,3-Benzodioxole – Wikipedia
Dioxole | C3H4O2 – PubChem

Extracurricular laboratory: Synthetic route of 80841-78-7

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps.

80841-78-7, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.80841-78-7. An updated downstream synthesis route of 80841-78-7 as follows.

Example 1(1) Tritylation and DMDO Esterification ReactionsAfter mixing 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2′-[1H-tetrazol-5-yl]biphenyl-4-yl]methyl]imidazole-5-carboxylic acid (30 g), acetone (210 mL), 1,8-diazabicyclo[5,4,0]-7-undecene [DBU] (25.5 g) and triphenylmethyl chloride [TPC] (23.79 g), water (0.6 mL) was added and acetone (30 mL) was poured into the mixture, and the reaction mixture was stirred at 48 to 52 C. for 2 hours. Then, water (0.9 mL) was added and 4-chloromethyl-5-methyl-1,3-dioxol-2-one [DMDO-Cl] (18.5 g) was poured in, and the reaction mixture was stirred at 48 to 52 C. for 5 hours.(2) Obtaining Crude Crystals of Trityl Olmesartan Medoxomil (Acetone Solvate Crystals)After the reaction mixture was cooled to 20 C. to precipitate crystals, it was stirred at 15 to 25 C. for 40 minutes, and water (96 mL) was added dropwise over a period of 25 minutes, and then the reaction mixture was cooled to 0 to 5 C. and stirred for 30 minutes. The precipitated crystals were filtered out and washed with acetone-water (150 mL), and wet crude crystals of (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2′-[2-(triphenylmethyl)-2H-tetrazol-5-yl]biphenyl-4-yl]methyl]imidazole-5-carboxylate (57.83 g) were obtained. These were then dried in vacuo at 60 C. for approximately 15 hours, and the dry acetone solvate crystals (57.50 g) were obtained.

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps.

Reference£º
Patent; DAIICHI SANKYO COMPANY, LIMITED; US2012/59172; (2012); A1;,
1,3-Benzodioxole – Wikipedia
Dioxole | C3H4O2 – PubChem

Share a compound : 37830-90-3

A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.37830-90-3. An updated downstream synthesis route of 37830-90-3 as follows., 37830-90-3

To a solution of 16 grams 4,5-dimethyl-1, 3-dioxol-2-one in CC14 (250 mE) was added N135 (23.4 g,131.5 mmol) and AII3N (1.3 g, 7.88 mmol), then the reaction mixture was heated to 80¡ã C. and stirred for 2 hrs. Monitored the starting material gone by TLC. The mixture was filtered and the filtrate was washed with water and brine, the organic phase was dried over Na2504 and concentrated to give crude product as a yellow oil which was used directly next step (25.3 g, yield 93percent).

Reference£º
Patent; KULING THERAPEUTICS; DING, Qiang; Wang, Xiaohu; (55 pag.)US2017/298090; (2017); A1;,
1,3-Benzodioxole – Wikipedia
Dioxole | C3H4O2 – PubChem

The important role of 80841-78-7

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand 4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one reaction routes.

Example 2; 36.0 g (50.3 mmol) ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-[2-(trityltetrazol-5-yl)-phenyl]phenyl}-methyl imidazole-5-carboxylate (Va) and 3.0 g (75.4 mmol) of NaOH were suspended in 413 ml dimethylacetamide. The suspension was then stirred at room temperature for 20 h and after that 6.9 g (50.3 mmol) of K2CO3 were added. The mixture was cooled to 0C and solution of 15.4 g (70.4 mmol) 4-chloromethyl-5-methyl-2-oxo-1,3-dioxolene in 39 ml of dimethylacetamide were slowly added. The mixture was slowly heated to 50C and stirred at this temperature for 2 h. After esterification was completed, the mixture was cooled to 10 C and poured into a mixture of 625 ml of ethyl acetate and 625 ml of 10 % NaCl, and stirred at 25 C for 15 min. The phases were separated and organic phase was washed 2x with 500 ml of 10 % NaCl, dried over Na2SO4 and filtered. The filtrate was concentrated up to ? (approximately 270 g) at reduced pressure. To the resulting solution, 80 ml of ethanol and 8.3 ml (100 mmol) of conc. HCl were added and stirred at 24-26C for 3h. To the cooled mixture 600 ml of water was added and pH of the suspension was estimated to 5 by addition of 5 M NaOH. The phases were stirred for 15 min and separated. Water phase was reextracted with 150 ml of ethyl acetate. Collected organic phases were dried over Na2SO4, filtered and concentrated under reduced pressure. 560 ml of ethyl acetate were added and the mixture was evaporated again. After that, 300 ml of ethyl acetate were added and the mixture was cooled to 20 C and stirred for 1h, filtered off and washed with 20 ml of fresh ethyl acetate. The yield of the product (I) was 21 g (75 %).

Reference£º
Patent; KRKA, tovarna zdravil, d.d., Novo mesto; EP1816131; (2007); A1;,
1,3-Benzodioxole – Wikipedia
Dioxole | C3H4O2 – PubChem

New learning discoveries about 4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps.

Example 5: The reaction part was charged with ethyl 4- (1-hydroxy-1-methylethyl) -2-propyl-1- {4- [2- (trityltetrazol-5-yl) phenyl] 22 g of 5-carboxylate (Formula 4), 3.1 g of sodium hydroxide and 90 mL of ethanol were added and the mixture was stirred at 20 to 25 C for 4 to 5 hours. When the reaction was completed, the reaction solution was concentrated. To the residue were added 50 mL of ethyl acetate and 50 mL of purified water. The mixture was stirred for 1 hour and then layered. The separated organic layer was washed twice with an aqueous solution containing 30 g of salt and 170 mL of purified water. 1 g of activated carbon and 20 g of anhydrous sodium sulfate were added to the organic layer, followed by stirring for 30 minutes to 1 hour, followed by filtration Respectively. After the filtrate was concentrated under reduced pressure, 50 mL of N, N-dimethylacetamide was added to the residue, the temperature was adjusted to 5 to 10 DEG C 4 g of potassium carbonate was added and 6.2 g of 4- (chloromethyl) -5-methyl-1,3-dioxol-2-one (Formula 6) was dissolved in N, N-dimethylacetamide 6 ML was added dropwise, and the mixture was reacted at 45 to 50 C for 4 hours with stirring. When the reaction is completed, the reaction solution is cooled to 20 to 25 After cooling, 220 mL of ethyl acetate, 30 g of salt and 170 mL of purified water were added successively. The organic layer was separated And then washed once more with an aqueous solution containing 30 g of salt and 170 mL of purified water. The organic layer was washed with 1 g of activated carbon, 20 g of sodium was added and stirred for 30 minutes to 1 hour, followed by filtration. The filtrate was concentrated under reduced pressure, and then acetone 100 mL of i-tril was added, and the mixture was stirred at 50 to 55 C for 1 hour. The crystals were cooled to 0 to 5 [deg.] C and stirred for 2 hours. Followed by washing with 50 mL of isopropyl alcohol, followed by drying to obtain 21.6 g (yield: 88%) of tritylolemecanemethoxysilane (formula 1a) Purity 99.97%) was obtained

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps.