Tag: M.W=100-150

Bucsi, Imre published the artcileTransformation of 1,2-diols over perfluorinated resinsulfonic acids (Nafion-H), Computed Properties of 1193-11-9, the publication is Tetrahedron (1994), 50(27), 8195-202, database is CAplus.

The transformations of 1,2-diols over perfluorinated resinsulfonic acids (Nafion-H) were studied and correlations were examined between the structures of the investigated diols, the possible dehydration routes and the catalytic properties of Nafion-H. Comparisons were also made between the catalytic properties of Nafion-H and NaHX zeolite. Because of its stronger acidity, Nafion-H functions at temperatures considerably lower than those for the usual dehydrating catalysts, e.g., the zeolites. As is well established for other solid electrophilic catalysts, the dehydration of 1,2-diols mainly proceeds via the pinacol rearrangement. The lower temperatures and the stronger acidity of Nafion-H strongly favor the pinacol rearrangement vs. 1,2-elimination. The reaction conditions are also advantageous for the formation of substituted 1,3-dioxolanes in a secondary condensation step between the unreacted diol and the primarily formed carbonyl compounds Nafion-H gradually deactivates during long use, but it can be partially reactivated by washing with acetone.

Tetrahedron published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Computed Properties of 1193-11-9.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Ikeda, Keiichi published the artcileRh(I)-Catalyzed cyclocarbonylation of enynes with glyceraldehyde: an available carbonyl source derived from sugar alcohols, Name: 1,4-Dioxaspiro[4.5]decane, the publication is Synlett (2012), 23(3), 393-396, database is CAplus.

Catalytic cyclocarbonylation reactions using a glyceraldehyde derivative as a carbonyl source are described. The rhodium(I)-catalyzed reaction of enynes, e.g., H₂C:CHCH₂OCH₂CCR ( R = Ph, n-Bu, CMe₃), with glyceraldehyde acetonide I gave bicyclic cyclopentenones, e.g., II, as the products. This presents an interesting use of a sugar alc. derived carbon resource as well as a convenient procedure for the cyclocarbonylation of enynes.

Synlett published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Name: 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Lamb, Thomas published the artcilePod-based menthol and tobacco flavored e-cigarettes cause mitochondrial dysfunction in lung epithelial cells, HPLC of Formula: 1193-11-9, the publication is Toxicology Letters (2020), 303-311, database is CAplus and MEDLINE.

Current FDA regulations have resulted in a ban of flavored e-cigarette pods, with only menthol and tobacco flavored pods being exempted. Previous work using menthol and tobacco-flavored e-cigarettes have been shown to induce mitochondrial reactive oxygen species. We hypothesized that exposure to pod-based JUUL Menthol and Virginia Tobacco aerosols will alter mitochondrial respiration and electron transport chain protein levels. We determined mitochondrial respiration by using a Seahorse technique and electron transport chain complexes by total OXPHOS antibodies after exposing lung epithelial cells, Beas-2b, to pod-based Menthol and Virginia Tobacco flavored aerosols. Menthol pod exposure resulted in an immediate increase in proton leak and decrease in coupling efficiency, as well as a decrease in complex I, II, and IV. Menthol pod exposure twenty-four hour post-exposure resulted in a decrease in basal respiration, maximal respiration, and spare capacity, as well as a decrease in complex I. Tobacco pod exposure resulted in no significant alterations to mitochondrial respiration, but immediately post final exposure resulted in a significant increase in complex I, IV, and V. Our results indicate that exposure to Menthol flavored e-cigarette pods cause mitochondrial dysfunction in lung epithelial cells.

Toxicology Letters published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, HPLC of Formula: 1193-11-9.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Kanai, Shunsuke published the artcileA bifunctional cerium phosphate catalyst for chemoselective acetalization, Recommanded Product: 1,4-Dioxaspiro[4.5]decane, the publication is Chemical Science (2017), 8(4), 3146-3153, database is CAplus and MEDLINE.

In this study, a CePO₄ catalyst was synthesized using a hydrothermal method and found to exhibit high catalytic performance for the chemoselective acetalization of 5-hydroxymethylfurfural with alcs., in sharp contrast to other homogeneous and heterogeneous acid and/or base catalysts. In the presence of CePO₄, various combinations of carbonyl compounds and alcs. are efficiently converted into the corresponding acetal derivatives in good to excellent yields. Mechanistic studies show that CePO₄ most likely acts as a bifunctional catalyst through the interaction of uniform Lewis acid and weak base sites with 5-hydroxymethylfurfural and alc. mols., resp., which results in high catalytic performance.

Chemical Science published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Recommanded Product: 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Quivoron, Claude published the artcileInvestigation, by infrared spectroscopy, of the proton-acceptor character of certain ethers and acetals, Name: 2,2,4-Trimethyl-1,3-dioxolane, the publication is Compt. Rend. (1964), 259(11), 1845-7, database is CAplus.

For iso-Pr₂O, THF, tetrahydropyran, and dioxane, the proton acceptor character has been determined by measuring the intensity of the O-H band of the unassocd. ο-cresol (diluted in CCl₄) vs. that of the H-bonded compound after the proton acceptor was added. (A) For the monoethers, the stability is higher for cyclic than for iso-Pr complexes, (B) THF is a stronger acceptor than tetrahydropyran at room temperature, the trend being reversed at -10°, and (C) the accumulation of 2 acceptor sites in dioxane causes a decreasing of the intrinsic basicity of each, the effect being emphasized if 2 O are bonded to the same C as in cyclic formals. The presence of electrorepulsive groups has a partial opposite effect.

Compt. Rend. published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Name: 2,2,4-Trimethyl-1,3-dioxolane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Quivoron, Claude published the artcileSecondary structure of polysaccharides. I. Proton acceptor character of oxygen atoms present in an acetal function by ir spectroscopy, Recommanded Product: 2,2,4-Trimethyl-1,3-dioxolane, the publication is Journal de Chimie Physique (1966), 63(9), 1199-209, database is CAplus.

In CCl4 solution, o-cresol gives H bond complexes with ethers, acetals, ether-acetals, and diacetals. Thermodynamic values K1, ΔG0, ΔH0, and ΔS0, characterizing these complexes were determined by ir spectroscopy. In the case of mols, containing several proton acceptor sites, it is possible to estimate intrinsic association constants which relate the participation of every heteroatom to the 1:1 complex equilibrium The acetal O atoms are probably the best proton acceptor sites contained in a polyglucosidic structure.

Journal de Chimie Physique published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Recommanded Product: 2,2,4-Trimethyl-1,3-dioxolane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Samoilov, Vadim published the artcileBio-based solvents and gasoline components from renewable 2,3-butanediol and 1,2-propanediol: synthesis and characterization, Safety of 2,2,4-Trimethyl-1,3-dioxolane, the publication is Molecules (2020), 25(7), 1723, database is CAplus and MEDLINE.

In this study approaches for chem. conversions of the renewable compounds 1,2- propanediol (1,2-PD) and 2,3-butanediol (2,3-BD) that yield the corresponding cyclic ketals and glycol ethers have been investigated exptl. Cyclic ketals have been obtained by the direct reaction of the diols with lower aliphatic ketones (1,2-PD + acetone → 2,2,4-trimethyl1,3-dioxolane (TMD) and 2,3-BD + butanone-2 → 2-ethyl-2,4,5-trimethyl-1,3-dioxolane (ETMD)), for which the ΔH⁰r, ΔS⁰r and ΔG⁰r values have been estimated exptl. The monoethers of diols could be obtained through either hydrogenolysis of the pure ketals or from the ketone and the diol via reductive alkylation. In the both reactions, the cyclic ketals (TMD and ETMD) have been hydrogenated in nearly quant. yields to the corresponding isopropoxypropanols (IPP) and 3- sec-butoxy-2-butanol (SBB) under mild conditions (T = 120-140°C, p(H2) = 40 bar) with high selectivity (>93%). Four products (TMD, ETMD, IPP and SBB) have been characterized as far as their phys. properties are concerned (d., melting/b.ps., viscosity, calorific value, evaporation rate, Antoine equation coefficients), as well as their solvent ones (Kamlet-Taft solvatochromic parameters, miscibility, and polymer solubilization). In the investigation of gasoline blending properties, TMD, ETMD, IPP and SBB have shown remarkable antiknock performance with blending antiknock indexes of 95.2, 92.7, 99.2 and 99.7 points, resp.

Molecules published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Safety of 2,2,4-Trimethyl-1,3-dioxolane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Samoilov, Vadim O. published the artcileThe Joint Synthesis of 1,2-Propylene Glycol and Isopropyl Alcohol by the Copper-Catalyzed Hydrogenolysis of Solketal, Name: 2,2,4-Trimethyl-1,3-dioxolane, the publication is ACS Sustainable Chemistry & Engineering (2019), 7(10), 9330-9341, database is CAplus.

A synthetic strategy from glycerol to 1,2-propylene glycol (1,2-PG) via heterogeneously catalyzed hydrogenolysis of solketal (2,2-dimethyl-4-(hydroxymethyl)-1,3-dioxolane) has been proposed for the first time. Upon the hydrogenolysis over 60 wt % Cu/Al₂O₃ at 200-240 °C, solketal has been converted into mixtures of isopropanol and 1,2-PG with high yield (up to 94 mol %). Under similar conditions, the catalyst specific productivity (a yield of 1,2-PG per unit of mass of the catalyst) was about 2.65 times higher, when solketal was the reaction feed instead of glycerol. The reaction was also performed under atm. pressure in the vapor phase, where the solketal hydrogenolysis gave 93 mol % selectivity to 1,2-PG with a conversion of 24%. A plausible reaction mechanism for the solketal hydrogenolysis has been proposed.

ACS Sustainable Chemistry & Engineering published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Name: 2,2,4-Trimethyl-1,3-dioxolane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Courtney, Timothy D. published the artcileLiquid-phase dehydration of propylene glycol using solid-acid catalysts, Recommanded Product: 2,2,4-Trimethyl-1,3-dioxolane, the publication is Applied Catalysis, A: General (2012), 59-68, database is CAplus.

In this work we combine experiments with D. Functional Theory (DFT) calculations to investigate the heterogeneous dehydration of propylene glycol. The reactions were carried out with pure, liquid propylene glycol over MFI-framework zeolite catalysts or the mesoporous sulfonic-acid resin Amberlyst 36Dry. When Amberlyst 36Dry was used, propylene glycol dehydrated to form propionaldehyde with 77% selectivity. All of the propionaldehyde further reacted with propylene glycol to form a cyclic acetal. The final products consisted of 78% acetal, 13% dipropylene glycol, and the remaining 9% was composed of acetone and a cyclic ketal formed from acetone. The zeolite catalysts demonstrated significantly higher selectivity toward dipropylene glycol compared to Amberlyst 36Dry. Furthermore, the zeolite had a lower conversion to cyclic acetals, improving the selectivity toward C3 products, acetone and propionaldehyde. DFT calculations confirmed that propionaldehyde is the favorable product in both catalysts, since it can be formed either through dehydration of the secondary hydroxyl group or via dehydration of the primary hydroxyl group with a concerted pinacol rearrangement. However, in the case of zeolites, the cyclic acetals experience steric hindrance since their size is comparable to that of the zeolite pores. Thus we argue that the cyclic acetals produced over the zeolite catalyst were formed homogeneously from the C3 products which diffused out of the zeolite pores.

Applied Catalysis, A: General published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Recommanded Product: 2,2,4-Trimethyl-1,3-dioxolane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Xiang, Shiyin published the artcileSynthesis of cyclohexanone ethylene ketal catalyzed by H₆P₂W₉Mo₉O₆₂/SiO₂, Recommanded Product: 1,4-Dioxaspiro[4.5]decane, the publication is Jingxi Shiyou Huagong Jinzhan (2017), 18(6), 45-48, database is CAplus.

H₆P₂W₉Mo₉O₆₂/SiO₂ was synthesized in a sol-gel process, and the thermal stability, structure and morphol. of H₆P₂W₉Mo₉O₆₂/SiO₂ were analyzed with X-ray diffractometer (XRD), FTIR Raman spectrometer, differential thermal analyzer (TG) and scanning electron microscope (SEM). Cyclohexanone ethylene ketal was synthesized with cyclohexanone and ethylene glycol as the reaction materials and H₆P₂W₉Mo₉O₆₂/SiO₂ as the catalyst, and the effects of the molar ratio of alc. ketone, the catalyst amount, the reaction time, and the cyclohexane amount on the synthesis of ketal were studied. According to the results, the yield of cyclohexanone ethylene ketal can reach 80.4% at the following conditions, i.e. n (cyclohexanone) : n (ethylene glycol)=1:1.3, the catalyst amount accounts for 0.8% of total reactants, and the reaction time is 45 min.

Jingxi Shiyou Huagong Jinzhan published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C13H18N2, Recommanded Product: 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem