Tag: 466.5675

Zhu, Jin et al. published their research in Tetrahedron: Asymmetry in 1997 | CAS: 93379-49-8

((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 93379-49-8

Resolution of alkyl pyridyl sulfoxides by complexation with a chiral host compound derived from tartaric acid was written by Zhu, Jin;Qin, Yong;He, Ze;Fu, Fang-Min;Zhou, Zhong-Yuan;Deng, Jin-Gen;Jiang, Yao-Zhong;Chau, Tay-Yuan. And the article was included in Tetrahedron: Asymmetry in 1997.Reference of 93379-49-8 This article mentions the following:

Alkyl pyridyl sulfoxides I (R = Me, Et) were prepared in high enantiomeric excess by resolution through inclusion complexation with a chiral host compound, (2R,3R)- or (2S,3S)-(-)-trans-4,5-bis(hydroxydiphenylmethyl)-2,2-dimethyl-1,3-dioxolane (II). The X-ray crystallog. structure anal. of complex (R,R)-(-)-II with (R)-(-)-I (R = Et) is reported. In the experiment, the researchers used many compounds, for example, ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8Reference of 93379-49-8).

((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 93379-49-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Hafner, Andreas et al. published their research in Journal of the American Chemical Society in 1992 | CAS: 93379-49-8

((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 93379-49-8

Enantioselective syntheses with titanium carbohydrate complexes. Part 7. Enantioselective allyltitanation of aldehydes with cyclopentadienyldialkoxyallyltitanium complexes was written by Hafner, Andreas;Duthaler, Rudolf O.;Marti, Roger;Rihs, Grety;Rothe-Streit, Petra;Schwarzenbach, Franz. And the article was included in Journal of the American Chemical Society in 1992.Reference of 93379-49-8 This article mentions the following:

The preparation, anal., and reactions of novel, highly stereoselective cyclopentadienyldialkoxyallyltitanium reagents, available in both enantiomeric forms, are described. Chiral monochlorotitanates are readily prepared from CpTiCl3 (Cp = cyclopentadienyl) or Cp*TiCl3 (Cp* = pentamethylcyclopentadienyl) and chiral 1,4-diols, which in turn are obtained from tartrate ester acetals by Grignard addition The resulting stable seven-membered titanacycles have been analyzed by 1H, 13C, and 49Ti NMR spectroscopy. The structures of two representatives, the complexes I (R = Cl, R1 = Ph, Me), are confirmed by x-ray diffraction. The allyl reagents are obtained from the chlorides by transmetalation with allyllithium, allylpotassium, or allyl Grignard compounds These reagents do not have to be isolated or purified for the ensuing reactions with aldehydes. Correlation of x-ray data and Ti NMR line widths with selectivity suggests that asym. distortion of the titanium coordination geometry could be essential for enantioface discrimination, rather than direct interactions of reactants with the chiral ligand. By variation of the ligand substituents, allyltitanates derived from chloride I (R = Cl, R1 = Ph) (with 2,2-dimethyl-α,α,α’,α’-tetraphenyl-1,3-dioxolane-3,4-dimethanol as the ligand) emerged as the most selective reagents. Excellent regio-, diastereo-, and enantioselectivities (usually ≥95% ee, ≥95% de) are obtained for reactions with various achiral and chiral aldehydes. The NMR spectra of the allyl and the crotyl complexes (R,R)-I (R = allyl, 2-butenyl, R1 = Ph) exhibit fast 1,3-shifts favoring the (E) isomer with titanium η1-bound to the unsubstituted allyl terminus. This equilibration, and also the equilibrations of other aryl-, alkoxy-, and silyl-substituted allyltitanium complexes, restricts this method to the preparation of branched regioisomers with the anti configuration. In the experiment, the researchers used many compounds, for example, ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8Reference of 93379-49-8).

((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 93379-49-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Wullschleger, Christoph W. et al. published their research in Chemistry – A European Journal in 2013 | CAS: 93379-49-8

((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Quality Control of ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol)

Synthesis and Biological Activity of 7,8,9-Trideoxy- and 7R Des-THP-Peloruside A was written by Wullschleger, Christoph W.;Gertsch, Juerg;Altmann, Karl-Heinz. And the article was included in Chemistry – A European Journal in 2013.Quality Control of ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) This article mentions the following:

The stereoselective syntheses of 7,8,9-trideoxypeloruside A I and a monocyclic peloruside A analog lacking the entire tetrahydropyran moiety II are described. The syntheses proceeded through the PMB-ether of an ω-hydroxy β-keto aldehyde as a common intermediate which was elaborated into a pair of diastereomeric 1,3-syn and -anti diols by stereoselective Duthaler-Hafner allylation and subsequent 1,3-syn or anti reduction One of these isomers was further converted into a tetrahydropyran derivative in a high-yielding Prins reaction, to provide the precursor for bicyclic analog I. Downstream steps for both syntheses included the substrate-controlled addition of a vinyl lithium intermediate to an aldehyde, thus connecting the peloruside side chain to C15 (C13) of the macrocyclic core structure in a fully stereoselective fashion. In the case of monocyclic II macrocyclization was based on ring-closing olefin metathesis, while bicyclic I was cyclized through Yamaguchi-type macrolactonization. The macrolactonization step was surprisingly difficult and was accompanied by extensive cyclic dimer formation. Peloruside A analogs I and II inhibited the proliferation of human cancer cell lines in vitro with micromolar and sub-micromolar IC50 values, resp. The higher potency of I highlights the importance of the bicyclic core structure of peloruside A for nM biol. activity. In the experiment, the researchers used many compounds, for example, ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8Quality Control of ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol)).

((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Quality Control of ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol)

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Hinze, Willie L. et al. published their research in Analytical Chemistry in 1985 | CAS: 93379-49-8

((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Safety of ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol)

Liquid chromatographic separation of enantiomers using a chiral β-cyclodextrin-bonded stationary phase and conventional aqueous-organic mobile phases was written by Hinze, Willie L.;Riehl, Terrence E.;Armstrong, Daniel W.;DeMond, Wade;Alak, Ala;Ward, Tim. And the article was included in Analytical Chemistry in 1985.Safety of ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) This article mentions the following:

A chiral stationary phase composed of chem. bonded β-cyclodextrin (β-CD) was used to sep. enantiomers of dansylsulfonamide, β-naphthamide, or β-naphthyl ester derivatives of amino acids, barbiturates, substituted phenylacetic acids, and dioxolanes. The separations are reasonably rationalized in terms of the inclusion process between the enantiomers and β-cyclodextrin and consideration of a 3-point attachment model. The effects of mobile-phase composition, temperature, and flow rate upon the observed enantiomeric selectivity and resolution were critically assessed. A brief prospectus on the usefulness of cyclodextrin chiral stationary phases in high-performance liquid chromatog. enantiomeric separations is presented. In the experiment, the researchers used many compounds, for example, ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8Safety of ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol)).

((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Safety of ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol)

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Wen, Jiwu et al. published their research in Journal of Molecular Catalysis A: Chemical in 2006 | CAS: 93379-49-8

((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application of 93379-49-8

Asymmetric pinacol coupling catalyzed by TADDOL-titanium complexes was written by Wen, Jiwu;Zhao, Jun;You, Tianpa. And the article was included in Journal of Molecular Catalysis A: Chemical in 2006.Application of 93379-49-8 This article mentions the following:

Chiral diols such as I, derived from tartaric acid, have been exploited in the asym. pinacol coupling reaction, and good to excellent diastereoselectivities and moderate to good enantioselectivities were obtained. In the experiment, the researchers used many compounds, for example, ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8Application of 93379-49-8).

((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application of 93379-49-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Datta, Simmi et al. published their research in Zeitschrift fuer Anorganische und Allgemeine Chemie in 2006 | CAS: 93379-49-8

((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 93379-49-8

TADDOLate as ligand in zirconium and hafnium chemistry was written by Datta, Simmi;Roesky, Peter W.. And the article was included in Zeitschrift fuer Anorganische und Allgemeine Chemie in 2006.Reference of 93379-49-8 This article mentions the following:

The enantiomeric pure TADDOLate complexes of the heavier Group 4 metals [(η5-C5H5)2M{(S,S)-TADDOLate}] (M = Zr, Hf) were prepared by treatment of (S,S)-TADDOL with 2.5 equiv of Bu Li followed by reaction with zirconocene and hafnocene dichloride, resp. The new complexes were characterized by standard anal./spectroscopic techniques and the solid-state structures of both compounds were established by single crystal x-ray diffraction. The title compounds are the 1st fully characterized TADDOLate complexes of Zr and Hf. In the experiment, the researchers used many compounds, for example, ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8Reference of 93379-49-8).

((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)bis(diphenylmethanol) (cas: 93379-49-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 93379-49-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem