Tag: 260.2836

Synthesis of Oxaphosphinane-Based Pseudo-disaccharides was written by Babouri, Rachida;Clarion, Ludovic;Rolland, Marc;Van der Lee, Arie;Kabouche, Zahia;Volle, Jean-Noel;Virieux, David;Pirat, Jean-Luc. And the article was included in European Journal of Organic Chemistry in 2017.Safety of (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol This article mentions the following:

The synthesis of pseudo-disaccharides, e.g. I and II, based on an oxaphosphinane heterocycle is described. Disaccharide mimetics, e.g. I and II, ere readily obtained through glycosylation of a hydroxy group with appropriately protected furanosyl or pyranosyl carbohydrates using a trichloroacetamidate coupling strategy. Selective or complete deprotection then produced the chiral pseudo-disaccharides in good yields. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Safety of (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Safety of (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Facile carbohydrate-mimetic modifications of poly(ethylene imine) carriers for gene delivery applications was written by Englert, Christoph;Fevre, Mareva;Wojtecki, Rudy J.;Cheng, Wei;Xu, Qingxing;Yang, Chuan;Ke, Xiyu;Hartlieb, Matthias;Kempe, Kristian;Garcia, Jeannette M.;Ono, Robert J.;Schubert, Ulrich S.;Yang, Yi Yan;Hedrick, James L.. And the article was included in Polymer Chemistry in 2016.Synthetic Route of C12H20O6 This article mentions the following:

Com.-available linear and branched PEIs (LPEI and BPEI) were chem.-modified with carbohydrates and carbohydrate-mimetics to improve biocompatibility. Hydroxyl moieties were installed in a close proximity via reaction of PEI’s amines with paraformaldehyde (pF) or glycidol. Mixing PEI with pF led to the formation of hemiaminal moieties as well as N-methylation of the backbone through an Eschweiler-Clarke-type rearrangement. The amount of attached hydroxyl groups depended on the initial amount of pF and the results were in agreement with NMR studies on model reactions with primary and secondary amines. The primary amines of BPEI triggered the ring-opening of glycidol and sugar-containing epoxides, in methanol and at room temperature PEI chains modified with pF displayed the same cytotoxicity as the parent polymer, unless a sufficient amount of pF was added to trigger N-methylation of the backbone. In contrast, glycidol and sugar-functionalized BPEIs exhibited lower toxicity but similar (if not higher) transfection efficiency as compared to unmodified BPEI. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Synthetic Route of C12H20O6).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Synthetic Route of C12H20O6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Reactions of several monosaccharide-derived alcohols with p-acetamidobenzenesulfonyl azide and DBU was written by Sacui, Iulia A.;Norris, Peter. And the article was included in Tetrahedron Letters in 2011.Application of 14131-84-1 This article mentions the following:

Attempted diazo transfer to 1-O-(2-phenylacetyl)-2,3;5,6-di-O-isopropylidene-α-D-mannofuranose using p-acetamidobenzenesulfonyl azide (p-ABSA) and DBU as base affords 1-O-(2-diazo-2-phenylacetyl)-2,3;5,6-di-O-isopropylidene-α-D-mannofuranose in low yield along with 2,3;5,6-di-O-isopropylidene-α-D-mannofuranose, 1-azido-2,3;5,6-di-O-isopropylidene-β-D-mannofuranose, as well as the unreacted starting material. The azido sugar likely arises from α-mannofuranosyl sulfonate ester formation, through displacement of azide from p-ABSA by the sugar lactol, followed by stereospecific displacement by azide anion on the furanosyl sulfonate ester. This outcome has been studied further with the conditions being applied to several common monosaccharide derivatives Accessible substrates afford the azido sugar in an overall one-pot alc.-to-azide conversion, while hindered substrates yield the sulfonate esters. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Application of 14131-84-1).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Application of 14131-84-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Dual Catalytic Strategy for Forging sp²-sp³ and sp³-sp³ Architectures via β-Scission of Aliphatic Alcohol Derivatives was written by Cong, Fei;Lv, Xin-Yang;Day, Craig S.;Martin, Ruben. And the article was included in Journal of the American Chemical Society in 2020.Related Products of 14131-84-1 This article mentions the following:

A dual platform for forging sp²-sp³ and sp³-sp³ carbon bonds via catalytic β-scission of aliphatic alc. derivatives with both aryl and alkyl halides is disclosed [e.g., I + p-(F₃C)C₆H₄Br → II (84%, 77% isolated) in presence of photocatalyst, Hantzsch ester under blue LED irradiation with Ni/(4,4′-di-tert-butyl-2,2′-bipyridyl)]. This protocol is distinguished by its wide substrate scope and broad applicability, even in the context of late-stage functionalization. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Related Products of 14131-84-1).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Related Products of 14131-84-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthetic studies on guanofosfocins – synthesis of 8-(mannopyranosyloxy)adenosine derivatives was written by Sugimura, Hideyuki;Kanamori, Hideyuki;Stansfield, Kevin. And the article was included in Tennen Yuki Kagobutsu Toronkai Koen Yoshishu in 1998.Recommanded Product: (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol This article mentions the following:

Two approaches for the synthesis of 8-(glycosyloxy)purine nucleoside, which is found in a recently isolated chitin synthase inhibitor-guanofosfocin, have been examined One contains substitution reaction of alc. with purine nucleoside bearing a leaving group at the 8 position. Through a number of model reactions using cyclohexanol as a nucleophile and 8-substituted adenosine derivatives as a substrate, we finally found that N⁶-benzoyl-8-bromoadenosine derivative (I; R = Br, R¹ = Bz, R² = 4,4′-dimethoxytrityl) reacted with sodium alkoxides derived from di-O-isopropylidene-α-D-mannoses (Q-H and Q¹-H), in DMF at room temperature to yield 8-(mannosyloxy)adenosines (I; R = Q, R¹ = Bz) and (I; R = Q¹, R¹ = Bz) and in reasonable yields. Another approach involves glycosylation reaction of 8-oxoadenosine derivatives with appropriate mannosyl donors. We found that N⁶-trityl-adenosine derivative (II) was a suitable substrate for this reaction. When 2,3,4,6-tetra-O-benzyl-α-D-mannosyl bromide was allowed to react with 8-hydroxyadenosine derivative (II) in the presence of silver carbonate in toluene at 60°C, 8-(mannosyloxy)adenosine (I; R = Q², R¹ = R² = Tr) is obtained in 79% yield. The 8-mannosyloxy products were isolated solely as α anomers, assigned by ¹J_C-H value of C-1 in the mannose moiety. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Recommanded Product: (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of partially protected 3-deoxy-oct-2-ulosonic acid was written by Zheng, Shan-shan;Huang, Jia-sheng;Gao, Liang;Yang, Jin-song. And the article was included in Huaxue Yanjiu Yu Yingyong in 2014.Formula: C12H20O6 This article mentions the following:

α, β-Octenoate was prepared by Wittig reaction of D-mannose, then was turned to the corresponding diol cyclic sulfite. By β-elimination and in situ trapping (DBU/TMSCl) into enol silyl ether, α-oxocarboxylic acid ester was obtained. With total eight steps yielding 36.3%, the synthesis of Et 4, 5:7, 8-di-O-isopropylidene-3-deoxy-β-D-manno-2-octulopyranosonate was completed. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Formula: C12H20O6).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Formula: C12H20O6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Organotransition metal modified sugars Part 21. Synthesis of organometallic disaccharides bearing two monosaccharide moieties linked by a chromium carbene spacer was written by Janes, E.;Dotz, K. H.. And the article was included in Journal of Organometallic Chemistry in 2001.Category: dioxole This article mentions the following:

Organometallic disaccharides containing a chromium carbene spacer have been synthesized from tetramethylammonium acetyl(pentacarbonyl)chromate(-I) (1) in a two-step protocol. An acylation/alcoholysis sequence applying di(isopropylidene)-protected glucose, mannose, galactose and fructose afforded O-glycoside methylcarbene complexes 6-9 in 29-84% yield. Upon reaction with 1,2:3,4-di-O-isopropylidene-α-D-galacto-hexodiald-1,5-ose, activated by TiCl₄, they undergo a trans-selective aldol condensation to give a 53-89% yield of chromium vinylcarbene O,C-disaccharides which are promising candidates for subsequent benzannulation, cyclopropanation, Diels-Alder- and Michael addition reactions. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Category: dioxole).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Stereoselective nucleophilic additions on sugar hemiacetal controlled by large-ring chelates was written by Carchon, G.;Chretien, F.;Chapleur, Y.. And the article was included in Carbohydrate Letters in 1996.Recommanded Product: (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol This article mentions the following:

The condensation of Me lithium and Me magnesium chloride on 2,3:4,6-di-O-isopropylidene-D-mannopyranose gave a single D-glycero-D-manno-heptitol, in contrast with the corresponding furanose derivative The stereochem. outcome of both reactions can be rationalized in terms of a large ring chelate formed by oxygen atom at C-5, the aldehyde and lithium or magnesium. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Recommanded Product: (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Total Synthesis of (-)-Orthodiffenes A and C was written by Liu, Jun;Liu, Yi;Zhang, Xing;Zhang, Chaoli;Gao, Yangguang;Wang, LinLin;Du, Yuguo. And the article was included in Journal of Organic Chemistry in 2012.Category: dioxole This article mentions the following:

The efficient and concise synthesis of (-)-orthodiffenes A (I) and C (II) has been accomplished for the first time in eight steps from readily available chiral synthons, D-mannose and D-Et lactate. Our work confirmed the complete structure of orthodiffenes A and C, including their absolute stereochem. The key steps of our total synthesis involved cis-fused THF cyclization, one-pot deprotection-lactonization, and intramol. benzoyl migration according to a biosynthetic hypothesis of orthodiffenes. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Category: dioxole).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Triphenylphosphine polymer-bound/iodine complex: a suitable reagent for the preparation of O-isopropylidene sugar derivatives was written by Pedatella, Silvana;Guaragna, Annalisa;D’Alonzo, Daniele;De Nisco, Mauro;Palumbo, Giovanni. And the article was included in Synthesis in 2006.Safety of (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol This article mentions the following:

O-Isopropylidene derivatives of sugars are readily prepared by using the Lewis acid and dehydrating agent triphenylphosphine polymer-bound/I₂ complex. This new method is characterized by smooth, non-equilibrating reaction conditions and a very clean, simple work-up, making it particularly suitable for O-isopropylidenation of sugars under mild conditions and with low environmental impact. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Safety of (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Safety of (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem