Tag: 244.6898

Mach, Robert H. et al. published their research in Journal of Medicinal Chemistry in 1992 | CAS: 3308-94-9

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C12H14ClFO2

Effect of N-alkylation on the affinities of analogs of spiperone for dopamine D2 and serotonin 5-HT2 receptors was written by Mach, Robert H.;Jackson, Joseph R.;Luedtke, Robert R.;Ivins, Kathryn J.;Molinoff, Perry B.;Ehrenkaufer, Richard L.. And the article was included in Journal of Medicinal Chemistry in 1992.Formula: C12H14ClFO2 This article mentions the following:

Two series of N-substituted spiperone analogs were prepared and evaluated in vitro to measure their affinities for dopamine D2 and serotonin 5-HT2 receptors. Substitution of the amide N with an alkyl group of 5 carbon units or less resulted in analogs displaying a low selectivity for D2 compared to 5-HT2 receptors. However, a moderate improvement in selectivity for D2 receptors was observed with N-benzylspiperone. Substitution at either the ortho or para position of the benzyl group resulted in a further reduction in affinity for 5-HT2 receptors and improvement in the selectivity ratio. Examination of N-substituted analogs of spiperone may provide insights into the topog. of the antagonist binding region of the 5-HT2 receptor. The results also suggest that an 18F-labeled analog of N-(4-nitrobenzyl)spiperone may be a suitable tracer for studying D2 receptors with positron emission tomog. since this compound displays a high selectivity for D2 receptors relative to that of spiperone and N-methylspiperone. In the experiment, the researchers used many compounds, for example, 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9Formula: C12H14ClFO2).

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C12H14ClFO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Ismaiel, Abd M. et al. published their research in Journal of Medicinal Chemistry in 1993 | CAS: 3308-94-9

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Synthetic Route of C12H14ClFO2

Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist was written by Ismaiel, Abd M.;De Los Angeles, Joseph;Teitler, Milt;Ingher, Stacy;Glennon, Richard A.. And the article was included in Journal of Medicinal Chemistry in 1993.Synthetic Route of C12H14ClFO2 This article mentions the following:

DOM [i.e., 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane] is a 5-HT1C/2 serotonin agonist that exerts stimulus control of behavior in animals. In order to determine if the discriminative stimulus effect of DOM is 5-HT1C– or 5-HT2-mediated, it would be informative to conduct tests of stimulus antagonism with a 5-HT1C or 5-HT2-selective antagonist. To date, no such agents exist. Although the neuroleptic agent spiperone binds at D2 dopamine receptors and 5-HT1A serotonin receptors, (a) it displays about a 1000-fold selectivity for 5-HT2 vs. 5-HT1C sites and (b) it has been used as a “5-HT2-selective” antagonist. Because spiperone is a behaviorally disruptive agent, it is not suitable for use in drug-discrimination studies. Using the spiperone mol. as a starting point, a limited structure-affinity investigation was conducted in order to identify a suitable antagonist with high affinity and selectivity for 5-HT2 receptors, and yet an antagonist that might lack the disruptive actions of spiperone. Various modifications of the spiperone mol. were examined, but most resulted in decreased 5-HT2 affinity or in loss of selectivity. One compound, 8-[3-(4-fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (I), was shown to bind at 5-HT2 sites with high affinity (Ki = 2 nM) and >2,000-fold selectivity vs. 5-HT1C sites. In tests of stimulus antagonism using rats trained to discriminate 1 mg/kg of DOM from saline vehicle, I behaved as a potent antagonist (ED50 = 0/003 mg/kg) and lacked the disruptive effects associated with spiperone. As such, (a) it would appear that the DOM stimulus is primarily a 5-HT2-mediated, and not 5-HT1C-mediated, phenomenon, and (b) compound I may find application in other pharmacol. investigations where spiperone may not be a suitable antagonist. In the experiment, the researchers used many compounds, for example, 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9Synthetic Route of C12H14ClFO2).

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Synthetic Route of C12H14ClFO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Stanetty, Peter et al. published their research in Archiv der Pharmazie (Weinheim, Germany) in 1984 | CAS: 3308-94-9

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Electric Literature of C12H14ClFO2

Heterocyclic spiro compounds: spiro[benzo[b]thiophene-4(5H),3′-pyrrolidines] was written by Stanetty, Peter;Froehlich, Hannes;Sauter, Fritz. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 1984.Electric Literature of C12H14ClFO2 This article mentions the following:

The title compounds were prepared and their 1H and 13C NMR studied. Condensing benzothiophenone I (Z = O) with (NC)2CH2 gave dicyano compound I [Z = C(CN)2] which was treated with NaCN and the product tricyano compound hydrolyzed and decarboxylated to give diacid II. Cyclization of II with RNH2 [R = H, Me, (CH2)3NEt2] gave the spiropyrrolidines III. III (R = H) and Cl(CH2)nNMe2 (n = 2,3) gave III [R = (CH2)nNMe2]. Reduction of III with LiAlH4 gave IV. In the experiment, the researchers used many compounds, for example, 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9Electric Literature of C12H14ClFO2).

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Electric Literature of C12H14ClFO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Mewshaw, Richard E. et al. published their research in Journal of Medicinal Chemistry in 1999 | CAS: 3308-94-9

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Related Products of 3308-94-9

New generation dopaminergic agents. 6. Structure-activity relationship studies of a series of 4-(aminoethoxy)indole and 4-(aminoethoxy)indolone derivatives based on the newly discovered 3-hydroxyphenoxyethylamine D2 template was written by Mewshaw, Richard E.;Webb, Michael B.;Marquis, Karen L.;McGaughey, Georgia B.;Shi, Xiaojie;Wasik, Theodore;Scerni, Rosemary;Brennan, Julie A.;Andree, Terrance H.. And the article was included in Journal of Medicinal Chemistry in 1999.Related Products of 3308-94-9 This article mentions the following:

A series of 4-(aminoethoxy)indoles I [R1 = CH2Ph, (CH2)4Ph, n- Bu, etc.; R2 = H, Me; NR1R2 = isoquinolino; X = H, Cl, Y = H, COCF3, Cl] and a related series of 4-(aminoethoxy)indolones II [R1 = Me, CH2Ph, 2-naphthyl, etc.; R2 = H, Me, (CH2)2, CH2; X = H, Cl, F] were synthesized and evaluated for their affinity for both the high- and low-affinity agonist states (D2High and D2Low, resp.) of the dopamine (DA) D2 receptor. The 4-aminoethoxy derivatives I and II were designed as bioisosteric analogs based on the phenol prototype 3-HOC6H4OCH2CH2NHCH2Ph. The indolones II were observed to have high affinity for the D2High receptor. Comparison of their previously reported chroman analogs with the more flexible 4-(aminoethoxy)indoles revealed the chroman analogs to be more potent, whereas little loss in D2High affinity was observed when comparing the 4-(aminoethoxy)indolones with their resp. chroman analogs. Several regions of the phenoxyethylamine framework were modified and recognized as potential sites to modulate the level of intrinsic activity. A conformational anal. was performed and a putative bioactive conformation was proposed which fulfilled the D2 agonist pharmacophore criteria based on the McDermed model. Structure-activity relationships gained from these studies have aided in the synthesis of D2 partial agonists of varying intrinsic activity levels. These agents should be of therapeutic value in treating disorders resulting from hypo- and hyperdopaminergic activity, without the side effects associated with complete D2 agonism or antagonism. In the experiment, the researchers used many compounds, for example, 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9Related Products of 3308-94-9).

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Related Products of 3308-94-9

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Masaguer, Christian F. et al. published their research in Chemical & Pharmaceutical Bulletin in 1999 | CAS: 3308-94-9

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Application In Synthesis of 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane

Conformationally restricted butyrophenones with mixed dopaminergic (D2) and serotoninergic (5-HT2A) affinities. Synthesis of 5-aminoethyl-and 6-aminomethyl-4-oxotetrahydroindoles as potential atypical antipsychotics was written by Masaguer, Christian F.;Casariego, Isabel;Ravina, Enrique. And the article was included in Chemical & Pharmaceutical Bulletin in 1999.Application In Synthesis of 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane This article mentions the following:

5-Aminoethyl- and 6-aminomethyl-4-oxotetrahydroindoles were synthesized as butyrophenone derivatives in the indole series, as potential atypical antipsychotics. The affinities of these compounds for serotonin (5-HT2A) and dopamine (D2) receptors were evaluated in vitro. The ratios of pKi‘s for 5-HT2A/D2 receptors may be useful for rapid screening of new compounds and assessing potential induction of extrapyramidal symptoms; ratio values ≥1.12 (Meltzer’s ratio) are predictive of an atypical antipsychotic profile. Two compounds, QF 0408B (I) and QF 0409B (II), showed high affinity for both D2 and 5-HT2A receptors, and their Meltzer’s ratios were 1.32 and 1.17 resp., while haloperidol showed a ratio of 0.93. In the experiment, the researchers used many compounds, for example, 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9Application In Synthesis of 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane).

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Application In Synthesis of 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Mewshaw, Richard E. et al. published their research in Journal of Medicinal Chemistry in 1999 | CAS: 3308-94-9

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Related Products of 3308-94-9

New generation dopaminergic agents. 6. Structure-activity relationship studies of a series of 4-(aminoethoxy)indole and 4-(aminoethoxy)indolone derivatives based on the newly discovered 3-hydroxyphenoxyethylamine D2 template was written by Mewshaw, Richard E.;Webb, Michael B.;Marquis, Karen L.;McGaughey, Georgia B.;Shi, Xiaojie;Wasik, Theodore;Scerni, Rosemary;Brennan, Julie A.;Andree, Terrance H.. And the article was included in Journal of Medicinal Chemistry in 1999.Related Products of 3308-94-9 This article mentions the following:

A series of 4-(aminoethoxy)indoles I [R1 = CH2Ph, (CH2)4Ph, n- Bu, etc.; R2 = H, Me; NR1R2 = isoquinolino; X = H, Cl, Y = H, COCF3, Cl] and a related series of 4-(aminoethoxy)indolones II [R1 = Me, CH2Ph, 2-naphthyl, etc.; R2 = H, Me, (CH2)2, CH2; X = H, Cl, F] were synthesized and evaluated for their affinity for both the high- and low-affinity agonist states (D2High and D2Low, resp.) of the dopamine (DA) D2 receptor. The 4-aminoethoxy derivatives I and II were designed as bioisosteric analogs based on the phenol prototype 3-HOC6H4OCH2CH2NHCH2Ph. The indolones II were observed to have high affinity for the D2High receptor. Comparison of their previously reported chroman analogs with the more flexible 4-(aminoethoxy)indoles revealed the chroman analogs to be more potent, whereas little loss in D2High affinity was observed when comparing the 4-(aminoethoxy)indolones with their resp. chroman analogs. Several regions of the phenoxyethylamine framework were modified and recognized as potential sites to modulate the level of intrinsic activity. A conformational anal. was performed and a putative bioactive conformation was proposed which fulfilled the D2 agonist pharmacophore criteria based on the McDermed model. Structure-activity relationships gained from these studies have aided in the synthesis of D2 partial agonists of varying intrinsic activity levels. These agents should be of therapeutic value in treating disorders resulting from hypo- and hyperdopaminergic activity, without the side effects associated with complete D2 agonism or antagonism. In the experiment, the researchers used many compounds, for example, 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9Related Products of 3308-94-9).

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Related Products of 3308-94-9

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Tacke, Reinhold et al. published their research in Organometallics in 2002 | CAS: 3308-94-9

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C12H14ClFO2

2-Methylimidazol-1-yl-Substituted Analogs of Hexahydro-difenidol (HHD) and Hexahydro-sila-difenidol (HHSiD) as M3 Receptor-Preferring Muscarinic Antagonists: A Study on C/Si Bioisosterism was written by Tacke, Reinhold;Handmann, Vera I.;Kreutzmann, Kai;Keim, Christine;Mutschler, Ernst;Lambrecht, Guenter. And the article was included in Organometallics in 2002.Formula: C12H14ClFO2 This article mentions the following:

The hexahydro-sila-difenidol (HHSiD, 1b) and p-fluoro-hexahydro-sila-difenidol (p-F-HHSiD, 2b) derivatives cyclohexyl[3-(2-methylimidazol-1-yl)propyl]phenylsilanol (4b) and cyclohexyl(4-fluorophenyl)[3-(2-methylimidazol-1-yl)propyl]silanol (5b) were synthesized in three-step syntheses, starting from (3-chloropropyl)cyclohexyldimethoxysilane. In addition, the corresponding carbon analogs 4a and 5a (→ Si/C replacement) were prepared in two-step syntheses, starting from 2-(3-chloropropyl)-2-phenyl-1,3-dioxolane and 2-(3-chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane, resp. The C/Si pairs 4a/4b and 5a/5b were studied for their affinities at recombinant human muscarinic M1, M2, M3, M4, and M5 receptors stably expressed in CHO-K1 cells by evaluating their ability to inhibit the binding of the muscarinic antagonist [3H]N-methylscopolamine. These studies revealed that compounds 4a, 4b, 5a, and 5b behave as simple competitive antagonists at M1-M5 receptors. The exchange of the piperidin-1-yl group of the parent compounds HHD (1a), HHSiD (1b), p-F-HHD (2a), and p-F-HHSiD (2b) by a 2-methylimidazol-1-yl moiety resulted in a novel, potent, and M3-preferring antimuscarinic agent, compound 4b. The affinities of compounds 4a, 5a, and 5b for muscarinic M1 (pKi = 7.74-7.93), M2 (pKi = 7.03-7.14), M3 (pKi = 8.04-8.11), M4 (pKi = 7.63-7.94), and M5 receptors (pKi = 7.29-7.52) were very similar at the individual receptor subtypes and in turn very similar to those of the parent compounds 1a, 2a, and 2b. In contrast, replacement of the piperidin-1-yl substituent of 1b by a 2-methylimidazol-1-yl group (→ 4b) increased the affinity for M1-M5 receptors up to 8.3-fold. The muscarinic receptor affinity profile of 4b was found to be M3 (pKi = 8.69) > M1 (pKi = 8.39) ≥ M4 (pKi = 8.32) > M5 (pKi = 8.02) > M2 (pKi = 7.43). Thus, compound 4b displayed a M3 vs. M2 receptor selectivity (18.2-fold). The receptor subtype affinities of the carbon compound 5a were very similar to those of the corresponding silicon analog 5b, whereas sila-substitution of 4a (→ 4b) increased the affinities for M1-M5 receptors, this increase being greatest at M3 and M5 receptors (4-fold). In the experiment, the researchers used many compounds, for example, 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9Formula: C12H14ClFO2).

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C12H14ClFO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Ravina, Enrique et al. published their research in Journal of Medicinal Chemistry in 1999 | CAS: 3308-94-9

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C12H14ClFO2

Conformationally constrained butyrophenones with mixed dopaminergic (D2) and serotoninergic (5-HT2A, 5-HT2C) affinities: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo- and -thienocycloalkanones as putative atypical antipsychotics was written by Ravina, Enrique;Negreira, Jesus;Cid, Jose;Masaguer, Christian F.;Rosa, Elizabeth;Rivas, M. Emilia;Fontenla, Jose A.;Loza, M. Isabel;Tristan, Helena;Cadavid, M. Isabel;Sanz, Ferran;Lozoya, Estrella;Carotti, Angelo;Carrieri, Antonio. And the article was included in Journal of Medicinal Chemistry in 1999.Formula: C12H14ClFO2 This article mentions the following:

A series of novel conformationally restricted butyrophenones (2-(aminoethyl)- and 3-(aminomethyl)thieno- or benzocycloalkanones bearing (6-fluorobenzisoxazolyl)piperidine, (p-fluorobenzoyl)piperidine, (o-methoxyphenyl)piperazine, or linear butyrophenone fragments) were prepared and evaluated as atypical antipsychotic agents by in vitro assays of affinity for dopamine receptors (D1, D2) and serotonin receptors (5-HT2A, 5-HT2C) and by in vivo assays of antipsychotic potential and the risk of inducing extra pyramidal side effects. Potency and selectivity depended mainly on the amine fragment connected to the cycloalkanone structure. As a group, compounds with a benzisoxazolyl fragment had the highest 5-HT2A activities, followed by the benzoylpiperidine derivatives; in general, α-substituted cycloalkanone derivatives were more active than the corresponding β-substituted congeners. CoMFA (comparative mol. field anal.) and docking studies showed electrostatic, steric, and lipophilic determinants of 5-HT2A and D2 affinities and 5-HT2A/D2 selectivity. The in vitro and in vivo pharmacol. profiles of N-[(4-oxo-4H-5,6-dihydrocyclopenta[b]thiophene-5-yl)ethyl]-4-(6-fluorobenzisoxazol-3-yl)piperidine (QF 0510B), N-[(4-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-5-yl)ethyl]-4-(6-fluorobenzisoxazol-3-yl)piperidine (QF 0610B), and N-[(7-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-6-yl)ethyl]-4-(6-fluorobenzisoxazol-3-yl)piperidine (QF 0902B) suggest that they may be effective antipsychotic drugs with low propensity to induce extra pyramidal side effects. In the experiment, the researchers used many compounds, for example, 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9Formula: C12H14ClFO2).

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C12H14ClFO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Clagett-Dame, Margaret et al. published their research in Biochimica et Biophysica Acta, Biomembranes in 1989 | CAS: 3308-94-9

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C12H14ClFO2

Preparation of an affinity chromatography matrix for the selective purification of the dopamine D2 receptor from bovine striatal membranes was written by Clagett-Dame, Margaret;Schoenleber, Robert;Chung, Christine;McKelvy, Jeffrey F.. And the article was included in Biochimica et Biophysica Acta, Biomembranes in 1989.Formula: C12H14ClFO2 This article mentions the following:

A ligand affinity matrix has been developed and utilized to purify the dopamine D2 receptor ∼2100-fold from bovine striatal membranes. 3-[2-Aminoethyl]-8-[3-(4-fluorobenzoyl)propyl]-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (AES) was synthesized and used to prepare the affinity matrix by coupling to epoxy-activated Sepharose 6B (AES-Sepharose). AES (Ki ≈ 1.7 nM) is similar in potency to the parent compound, spiperone (Ki ≈ 0.8 mM), in competing for [3H]spiperone-binding activity. AES has no significant potency in competing for the dopamine D1 receptor as assessed by competition for [3H]SCH23390 binding (K2 > 1 μM)9. Covalent photoaffinity labeling of the dopamine D2 receptor in bovine striatal membranes with N-(p-azido-m-[125I]iodophenethyl)spiperone ([125I]N3-NAPS) was prevented by AES at nanomolar concentrations The dopamine D2 receptor was solubilized from bovine striatal membranes using 0.25% cholate in the presence of high ionic strength, followed by precipitation and subsequent treatment with 0.5% digitonin. Nearly 100% of the [3H]spiperone-binding activity in the cholate-digitonin solubilized preparation was adsorbed at a receptor-to-resin ratio of 2:1 (volume/volume). Dopamine D2 receptor was eluted from the affinity resin using a competing dopaminergic antagonist mol., haloperidol. Recovery of dopamine D2 receptor activity from the affinity matrix was ∼9% of the activity adsorbed to the resin. The [3H]spiperone-binding activity in AES-Sepharose affinity purified preparations is saturable and of high affinity (0.2 nM). Affinity-purified preparations maintain the ligand-binding characteristics of a dopamine D2 receptor as assessed by agonist and antagonist competition for [3H]spiperone binding. In the experiment, the researchers used many compounds, for example, 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9Formula: C12H14ClFO2).

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C12H14ClFO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem