Tag: 200-300

One-step synthesis of substituted 2-aryl-2-(bromoalkyl)-1,3-dioxolanes was written by Svoboda, Jiri;Palecek, Jaroslav;Dedek, Vaclav;Mostecky, Jiri. And the article was included in Collection of Czechoslovak Chemical Communications in 1984.Recommanded Product: 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

Bromoketalization of p-RC₆H₄COCHR¹R² (R = H, Me₂CHCH₂, Ph, Me, R¹ = R² = H; R = Me₂CHCH₂, R¹ = H, R² = Me; R = H, R¹ = R² = Me) with ethylene glycol and pyridinium perbromide, dioxane dibromide or PhN⁺Me₃ Br₃^– gave 35-84% I. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Recommanded Product: 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Recommanded Product: 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

A mild and efficient method for one-step α-haloacetalization of acetophenones using 1,3-dihalo-5,5-dimehtylhydantoin in ethylene glycol was written by Zheng, Zu Biao;Li, Zhong Zhou;Han, Bing Bing;He, Zai Ming;Shi, Teng Fei;Cheng, Peng. And the article was included in Tetrahedron Letters in 2015.Recommanded Product: 3418-21-1 This article mentions the following:

A mild and efficient method that could directly prepare α-haloacetal acetophenones from various acetophenones with 1,3-dihalo-5,5-dimehtylhydantoin (DBDMH/DCDMH) and ethylene glycol in good yields without catalysts was reported. The effects of solvents, 1,3-dihalo-5,5-dimehtylhydantoin, and reaction temperature were investigated. Under the optimal condition, most of α-haloacetal acetophenones were obtained in 65-97% yields. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Recommanded Product: 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

An eco-friendly and efficient synthesis of benzoylformic acid and methyl benzoylformate from styrene was written by Dai, Zhihong;Peng, Xinhua;Dong, Xiongzi;Shi, Chunjie;Rong, Yuan. And the article was included in Asian Journal of Chemistry in 2012.Recommanded Product: 3418-21-1 This article mentions the following:

The HBr/H₂O₂ system was found to be a highly efficient and green catalytic system for the selective oxidation of styrene. The method was utilized for the synthesis of phenylglyoxalic acid in excellent yields using water as solvent. Subsequent esterification is simple, highly efficient, and inexpensive by using TiO₂/SO₄^2- as catalyst. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Recommanded Product: 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Recommanded Product: 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Optimization of Grignard ring-opening of α-brominated dioxolanes for the preparation of β-hydroxy-protected vinyl ethers by a three-step one-pot procedure was written by Andre, Mathieu;Letribot, Boris;Bayle, Martine;Mounetou, Emmanuelle;Chezal, Jean-Michel. And the article was included in Tetrahedron Letters in 2012.Reference of 3418-21-1 This article mentions the following:

Aliphatic, cyclic, and aromatic benzoate-protected γ-hydroxy enol ethers were prepared from α-brominated dioxolanes by a three-step reaction procedure and a one-pot protocol involving Grignard reagent formation, ring-opening, and final benzoate protection. E.g., addition of Mg to the α-brominated dioxolane (I), followed by treatment with NEt₃, then with benzoyl chloride gave 61% benzoate-protected γ-hydroxy enol ether (II). Addnl., tert-butyldiphenylsilyl, acetate, and 4,4′-dimethoxytrityl were also successfully used as alternative protecting groups. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Reference of 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Vibrational circular dichroism and absolute configuration of 1-substituted indans was written by Fontana, Luca P.;Chandramouly, Tummalapalli;Smith, Howard E.;Polavarapu, Prasad L.. And the article was included in Journal of Organic Chemistry in 1988.Electric Literature of C10H11BrO2 This article mentions the following:

Vibrational CD (VCD) spectra of title compounds (R)- and (S)-I (R = NH₂, R¹ = H), (S)-I (R = Me, R¹ = H), and (R)-I (R = Me, R¹ = D) were measured at 800-1600 cm^-1. The VCD feature associated with the C^*-H bending mode at ∼1350 cm^-1 correlated with their absolute configurations. This correlation agrees with one found for (S)-methyloxirane and (R)-methylthiirane, and reflects the potential importance of VCD measurements in stereochem. anal. of chiral rings systems. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Electric Literature of C10H11BrO2).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Electric Literature of C10H11BrO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Reaction of monohalocarbenes with 2-phenyl-1,3-dioxolane and 4-phenyl-1,3-dioxan was written by Safiev, O. G.;Nazarov, D. V.;Zorin, V. V.;Rakhmankulov, D. L.;Paushkin, Yu. M.. And the article was included in Doklady Akademii Nauk SSSR in 1988.Category: dioxole This article mentions the following:

Carbenes :CHX (X = Cl, Br), generated acoustically from CH₂X₂, solid KOH and PhCH₂NEt₃⁺ Cl^–, inserted into the benzylic C:H bond of the title compounds to give 73-94% 2- and 4-(halomethyl) derivatives, resp. The carbenes were trapped with Me₂C:CMe₂ to give the corresponding halotetramethylcyclopropanes in 87-95% yield. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Category: dioxole).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Acetal and ketal hydrolysis rates in moderately concentrated perchloric acid solutions containing 50% dioxane was written by Kreevoy, Maurice M.. And the article was included in Journal of the American Chemical Society in 1956.Electric Literature of C10H11BrO2 This article mentions the following:

By Kühn’s method (C.A. 35, 1762⁷) were prepared R₁R₂COCH₂CH₂O (I) with R₁ = Ph, R₂ = CH₂CN (II), m. 45.5-46.3°, and R₁ = PhCH₂, R₂ = Me (III), b₁₅ 109°. The acid-catalyzed rates (k) of hydrolysis of CH₂ClC(OEt)₂, of I (R₁ = Ph, R₂ = CH₂Br), and of II and III were determined in a solvent containing 50% dioxane as a function of HClO₄ concentration The ratio of free base to conjugate acid [BH⁺]/[B] for 2-nitro-4-chloroaniline was determined in the same solvent. The quantities log {k/[HClO₄]} and log {[BH⁺]/[B] [HClO₄]} are linear functions of [HClO₄] with approx. equal slopes. Some possible implications of these relations are discussed. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Electric Literature of C10H11BrO2).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Electric Literature of C10H11BrO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Novel Dioxolane Ring Compounds for the Management of Phytopathogen Diseases as Ergosterol Biosynthesis Inhibitors: Synthesis, Biological Activities, and Molecular Docking was written by Min, Li-Jing;Wang, Han;Bajsa-Hirschel, Joanna;Yu, Chen-Sheng;Wang, Bin;Yao, Meng-Meng;Han, Liang;Cantrell, Charles L.;Duke, Stephen O.;Sun, Na-Bo;Liu, Xing-Hai. And the article was included in Journal of Agricultural and Food Chemistry in 2022.SDS of cas: 3418-21-1 This article mentions the following:

Thirty novel dioxolane ring compounds were designed and synthesized. Their chem. structures were confirmed by ¹H NMR, HRMS and single crystal X-ray diffraction anal. Bioassays indicated that these dioxolane ring derivatives exhibited excellent fungicidal activity against Rhizoctonia solani, Pyricularia oryzae, Botrytis cinerea, Colletotrichum gloeosporioides, Fusarium oxysporum, Physalospora piricola, Cercospora arachidicola, and herbicidal activity against lettuce (Lactuca sativa), bentgrass (Agrostis stolonifera) and duckweed (Lemna pausicostata). Among these compounds, 1-((2-(4-chlorophenyl)-5-methyl-1,3-dioxan-2-yl)methyl)-1H-1,2,4-triazole (D17), 1-(((4R)-2-(4-chlorophenyl)-4-methyl-1,3-dioxolan-2-yl)methyl)-1H-1,2,4-triazole (D20), 1-((5-methyl-2-(4-(trifluoromethyl)phenyl)-1,3-dioxan-2-yl)methyl)-1H-1,2,4-triazole (D22) and 1-((2-(4-fluorophenyl)-1,3-dioxolan-2-yl)methyl)-1H-1,2,4-triazole (D26) had broad spectrum fungicidal and herbicidal activity. The IC₅₀ values against duckweed were 20.5 ± 9.0, 14.2 ± 6.7, 24.0 ± 11.0, 8.7 ± 3.5 and 8.0 ± 3.1μM for D17, D20, D22, D26 and pos. control difenoconazole, resp. The EC₅₀ values were 7.31 ± 0.67, 9.74 ± 0.83, 17.32 ± 1.23, 11.96 ± 0.98 and 8.93 ± 0.91 mg/L for D17, D20, D22, D26 and the pos. control difenoconazole against the plant pathogen R. solani, resp. Germination experiments with Arabidopsis seeds indicated that the target of these dioxolane ring compounds in plants is brassinosteroid biosynthesis. Mol. simulation docking results of compound D26 and difenoconazole with fungal CYP51 P 450 confirmed that they both inhibit this enzyme involved in ergosterol synthesis. The structure-activity relationships (SAR) are discussed by substituent effect, mol. docking and d. functional theory anal., which provided useful information for designing more active compounds In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1SDS of cas: 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.SDS of cas: 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and some reactions of indolo[2,1-c]-1,4-oxazinium perchlorates was written by Kibalny, A. V.;Nikolyukin, Yu. A.;Dulenko, V. I.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1994.Application of 3418-21-1 This article mentions the following:

Title compounds I (R = Me, Et, Pr, CHMe₂, CMe₃, Ph) were prepared by reaction of 1-phenacylskatole with RCO⁺ClO₄^–. I were converted to pyrazine analogs (II; R = alkyl), dimeric compounds (III; R¹ = H, Me), and indolotriazepine IV. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Application of 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Application of 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Cationic Gold Catalyzes ω-Bromination of Terminal Alkynes and Subsequent Hydroaddition Reactions was written by Leyva-Perez, Antonio;Rubio-Marques, Paula;Al-Deyab, Salem S.;Al-Resayes, Saud I.;Corma, Avelino. And the article was included in ACS Catalysis in 2011.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

Orthogonal σ,π-bisfunctionalization of terminal alkynes can be achieved with a cationic gold complex in catalytic amounts First, the terminal C-H bond is transformed to the corresponding bromoalkyne which is then activated toward nucleophilic attack. This reactivity correlates with the structural nature of isolated gold-alkyne complexes. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem