Tag: 173.1169

Reddy, Mudumala Veeranarayana et al. published their research in Tetrahedron Letters in 2011 | CAS: 1544-85-0

2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.SDS of cas: 1544-85-0

BF3·SiO2-catalyzed one-pot synthesis of α-aminophosphonates in ionic liquid and neat conditions was written by Reddy, Mudumala Veeranarayana;Dindulkar, Someshwar D.;Jeong, Yeon Tae. And the article was included in Tetrahedron Letters in 2011.SDS of cas: 1544-85-0 This article mentions the following:

α-Aminophosphonates were synthesized in a simple and efficient method from the three-component condensation reaction of 5-amino 2,2-difluoro-1,3-benzodioxole, aromatic aldehydes, and di-Et phosphite by silica-supported boron trifluoride (BF3·SiO2) in ionic liquid ([bmim][HCl]) under solvent-free conditions at room temperature in good to excellent yields and short reaction times. The catalyst can be recovered and reused for several times without any significant loss of activity. It was observed that a homogeneous reaction medium proved beneficial for the yield of the reaction. In the experiment, the researchers used many compounds, for example, 2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0SDS of cas: 1544-85-0).

2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.SDS of cas: 1544-85-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Fischer, Christian et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2012 | CAS: 1544-85-0

2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Electric Literature of C7H5F2NO2

Triazoloamides as potent γ-secretase modulators with reduced hERG liability was written by Fischer, Christian;Zultanski, Susan L.;Zhou, Hua;Methot, Joey L.;Shah, Sanjiv;Nuthall, Hugh;Hughes, Bethany L.;Smotrov, Nadja;Hill, Armetta;Szewczak, Alexander A.;Moxham, Christopher M.;Bays, Nathan;Middleton, Richard E.;Munoz, Benito;Shearman, Mark S.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Electric Literature of C7H5F2NO2 This article mentions the following:

Synthesis and SAR studies of novel aryl triazoles as gamma secretase modulators (GSMs) are presented in this communication. Starting from aryl triazole leads, optimization studies were continued and the series progressed towards novel amides and lactams. Triazole I was identified as the most potent analog in this series, displaying single-digit nanomolar Aβ42 IC50 in cell-based assays and reduced affinity for the hERG channel. In the experiment, the researchers used many compounds, for example, 2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0Electric Literature of C7H5F2NO2).

2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Electric Literature of C7H5F2NO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Reddy, Mudumala Veeranarayana et al. published their research in Tetrahedron Letters in 2011 | CAS: 1544-85-0

2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.SDS of cas: 1544-85-0

BF3·SiO2-catalyzed one-pot synthesis of α-aminophosphonates in ionic liquid and neat conditions was written by Reddy, Mudumala Veeranarayana;Dindulkar, Someshwar D.;Jeong, Yeon Tae. And the article was included in Tetrahedron Letters in 2011.SDS of cas: 1544-85-0 This article mentions the following:

α-Aminophosphonates were synthesized in a simple and efficient method from the three-component condensation reaction of 5-amino 2,2-difluoro-1,3-benzodioxole, aromatic aldehydes, and di-Et phosphite by silica-supported boron trifluoride (BF3·SiO2) in ionic liquid ([bmim][HCl]) under solvent-free conditions at room temperature in good to excellent yields and short reaction times. The catalyst can be recovered and reused for several times without any significant loss of activity. It was observed that a homogeneous reaction medium proved beneficial for the yield of the reaction. In the experiment, the researchers used many compounds, for example, 2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0SDS of cas: 1544-85-0).

2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.SDS of cas: 1544-85-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Sharma, Swagat et al. published their research in ACS Medicinal Chemistry Letters in 2022 | CAS: 1544-85-0

2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Name: 2,2-Difluorobenzo[d][1,3]dioxol-5-amine

Synthesis and Biological Characterization of a Series of 2-Sulfonamidebenzamides as Allosteric Modulators of MrgX1 was written by Sharma, Swagat;Peng, Qi;Vadukoot, Anish K.;Aretz, Christopher D.;Jensen, Aaron A.;Wallick, Alexander I.;Dong, Xinzhong;Hopkins, Corey R.. And the article was included in ACS Medicinal Chemistry Letters in 2022.Name: 2,2-Difluorobenzo[d][1,3]dioxol-5-amine This article mentions the following:

The present study describes the continued efforts in the discovery and characterization of a series of 2-sulfonamidebenzamides e.g., 3-(Cyclopropanesulfonamido)-N-(2-ethoxyphenyl)-2-naphthamide as allosteric modulators of MrgX1. MrgX1 has been shown to be an attractive target as a nonopioid receptor for the potential treatment of chronic pain. Working from the original compound, ML382, and utilizing iterative medicinal chem., key halogen substituents that improve MrgX1 potency by ~8-fold were identified. In addition, the compounds in Tier 1 drug metabolism and pharmacokinetics assays were evaluated and the key compounds that impart improved potency and microsomal stability were identified. In the experiment, the researchers used many compounds, for example, 2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0Name: 2,2-Difluorobenzo[d][1,3]dioxol-5-amine).

2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Name: 2,2-Difluorobenzo[d][1,3]dioxol-5-amine

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem