Tag: 167.0012

Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein-Ligand X-ray Structure and Biological Evaluation was written by Ghosh, Arun K.;Takayama, Jun;Rao, Kalapala Venkateswara;Ratia, Kiira;Chaudhuri, Rima;Mulhearn, Debbie C.;Lee, Hyun;Nichols, Daniel B.;Baliji, Surendranath;Baker, Susan C.;Johnson, Michael E.;Mesecar, Andrew D.. And the article was included in Journal of Medicinal Chemistry in 2010.Application In Synthesis of 2-Bromomethyl-1,3-dioxolane This article mentions the following:

The design, synthesis, X-ray crystal structure, mol. modeling, and biol. evaluation of a series of new generation SARS-CoV PLpro inhibitors are described. A new lead compound 3 (6577871) was identified via high-throughput screening of a diverse chem. library. Subsequently, we carried out lead optimization and structure-activity studies to provide a series of improved inhibitors that show potent PLpro inhibition and antiviral activity against SARS-CoV infected Vero E6 cells. Interestingly, the (S)-Me inhibitor 15h (enzyme IC₅₀ = 0.56 μM; antiviral EC₅₀ = 9.1 μM) and the corresponding (R)-Me 15g (IC₅₀ = 0.32 μM; antiviral EC₅₀ = 9.1 μM) are the most potent compounds in this series, with nearly equivalent enzymic inhibition and antiviral activity. A protein-ligand X-ray structure of 15g-bound SARS-CoV PLpro and a corresponding model of 15h docked to PLpro provide intriguing mol. insight into the ligand-binding site interactions. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Application In Synthesis of 2-Bromomethyl-1,3-dioxolane).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Application In Synthesis of 2-Bromomethyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Ruthenium(II)biscarboxylate-Catalyzed Hydrogen-Isotope Exchange by Alkene C-H Activation was written by Bechtoldt, Alexander;Ackermann, Lutz. And the article was included in ChemCatChem in 2019.Name: 2-Bromomethyl-1,3-dioxolane This article mentions the following:

Ruthenium(II) biscarboxylate catalysis enabled efficient hydrogen isotope exchange of acrylic C-H bonds with user-friendly D₂O. The C-H labeling was characterized by excellent positional selectivity and a broad functional group tolerance. The deuteration was successfully conducted on 55 mmol scale with TONs of >1000, while mechanistic studies provided insights into ruthenium(II) oxidase catalysis. The obtained deuterated alkenes enabled the synthesis of labeled standards for mass spectrometry of irradiated foodstuffs. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Name: 2-Bromomethyl-1,3-dioxolane).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Name: 2-Bromomethyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and biological screening of S-substituted derivatives of 5-{1-[(4-chlorophenyl)sulfonyl]-3-piperidinyl}-1,3,4-oxadiazol-2-yl sulfide was written by Nafeesa, Khadija;Aziz-ur-Rehman;Abbasi, M. Athar;Siddiqui, Sabahat Z.;Rasool, Shahid;Hussain, Ghulam;Ahmed, Irshad. And the article was included in Asian Journal of Chemistry in 2015.Electric Literature of C4H7BrO2 This article mentions the following:

In present research, a novel series of S-substituted derivatives of 5-[1-[(4-chlorophenyl)sulfonyl]-3-piperidinyl]-1,3,4-oxadiazole-2-thiol I [R = (CH₂)₂Br, i-Pr, s-Bu, etc.] were synthesized by a multistep protocol starting from Et piperidine-3-carboxylate, which reacted with (4-chlorobenzene)sulfonyl chloride. The resulting Et 1-[(4-chlorophenyl)sulfonyl]piperidine-3-carboxylate was subsequently converted into its corresponding carbohydrazide and then to the 2,5-disubstituted-1,3,4-oxadiazole by intermol. cyclization. The compound 5-[1-(4-chlorophenylsulfonyl)-3-piperidinyl]-1,3,4-oxadiazole-2-thiol was derivatized by different alkyl halides. All of the synthesized compounds were screened for antibacterial activity and enzyme inhibition potential against lipoxygenase enzyme. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Electric Literature of C4H7BrO2).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Electric Literature of C4H7BrO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Asymmetric Sulfinylations of N-Methylephedrine-Modified Tri- or Tetraalkyl Zincates by Symmetric Diaryl Sulfoxides was written by Ruppenthal, Simon;Brueckner, Reinhard. And the article was included in European Journal of Organic Chemistry in 2018.Product Details of 4360-63-8 This article mentions the following:

Diethylzinc was treated with 1 or 2 equivalent of AlkMgCl or PhMgBr (preferably) or with 1 equivalent of nBuLi (less efficiently) for forming species – plausibly zincates – which were sulfinylated by diaryl sulfoxides to give racemic alkyl aryl sulfoxides in yields reaching 100 %. Dialkylzinc reagents were also activated by treatments with 1 or 2 equivalent of an enantiomerically pure alkylmagnesium β-aminoalkoxide. This worked best when the alkoxide stemmed from a dialkylmagnesium reagent and an equimolar amount of N-methyl-(-)-ephedrine. This second activation mode allowed sulfinylations of what was originally the dialkylzinc reagent with diaryl sulfoxides. This generated alkyl aryl sulfoxides with enantiomeric ratios up to 93:7 in up to 100 % yield. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Product Details of 4360-63-8).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Product Details of 4360-63-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem