Tag: 142.1956

Chemical composition and biological activity of the volatile oils of Hyptis spicigera against Trypanosoma brucei brucei, (Tbb) found in Northern Nigeria was written by Ladan, Z.;Amupitan, J. O.;Oyewale, O. A.;Okonkwo, E. M.;Ladan, E. O.;Odjobo, B.;Habila, N.. And the article was included in African Journal of Pure and Applied Chemistry in 2011.COA of Formula: C8H14O2 This article mentions the following:

The hydrodistillation of the fresh leaves of Hyptis spicigera gave a colorless volatile oil with yield of 0.65%. The volatile oil gave forty compounds on the basis of gas chromatog.-mass spectroscopy (GC-MS) with low composition of cineole (4.11%) and caryophyllene (2.61%) while α-pinene (12.16%) β-pinene (9.47%) and α-phellandrene (10.19%) were predominant compounds The biol. activity of the volatile oils was evaluated in vitro for activity against Trypanosoma brucei brucei (Tbb) and was found to possess anti-trypanosoma activity in vitro in a dose dependent pattern at 0.5 μg/mL in 6 min. This activity showed the volatile oils from H. spicigera leaves to be a potential trypanocide. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6COA of Formula: C8H14O2).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.COA of Formula: C8H14O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Binding of anti-Trypanosoma natural products from African flora against selected drug targets: a docking study was written by Ibezim, Akachukwu;Debnath, Biplab;Ntie-Kang, Fidele;Mbah, Chika John;Nwodo, Ngozi Justina. And the article was included in Medicinal Chemistry Research in 2017.Computed Properties of C8H14O2 This article mentions the following:

Recent publications have suggested that African medicinal plants and their derived products could be viable source of new and better trypanocidal drugs. Nowadays, in silico methods are often used in drug discovery processes to identify new potential drug leads. In this study, the authors have developed a small library named Afrotryp, comprising three-dimensional chem. structures of potential trypanocidal compounds derived from medicinal plants in Africa (a total of 321 unique chem. structures). The authors have predicted the pharmacokinetic properties of the library using Qikprop software and employed the three docking/scoring methods implemented in Mol. Operating Environment Dock Tool to assess the affinity of the library dataset towards the binding site of six selected validated anti-Trypanosoma drug targets. It was observed that about 42% of the compounds contained in the Afrotryp dataset were predicted to show a good overall performance in terms of predicted parameters for absorption, distribution, metabolism, elimination and toxicity properties. Docking calculations identified 15 compounds with lowest theor. binding energies toward the studied proteins, nine of which are suited for the treatment of stage 2 human African trypanosomiasis, due to their low polar surface area. Anal. of their binding modes gave basis for the observed unique mol. interactions which exist between the Afrotryp dataset and the six studied drug targets. The results lay the foundations for the rational development of novel trypanocidal drugs with improved potency. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6Computed Properties of C8H14O2).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Computed Properties of C8H14O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Catalytic synthesis of cyclohexanone ethylene ketal with solid superacid SO₄^2-/ZrO₂ was written by Wang, Junli;Meng, Shuangming;Guo, Yong;Zhao, Qiang;Fan, Yueqin. And the article was included in Huagong Keji in 2009.Recommanded Product: 177-10-6 This article mentions the following:

The solid superacid SO₄^2-/ZrO₂ catalyst was prepared and used for the synthesis of cyclohexanone ethylene ketal by ketal reaction. The effect of molar ratio of cyclohexanone to ethylene glycol, reaction time, catalyst amount, amount of the water-entraining agent and calcination temperature on the ketal reaction had been investigated. The optimum conditions are as follows: molar ratio of cyclohexanone to ethylene glycol is 1:1.5, the quantity of catalyst is equal to 0.5% of feed stock, cyclohexane is used as water-entraining agent, and reaction time is 60 min, solid superacid SO₄^2-/ZrO₂ is a good catalyst for synthesizing cyclohexanone ethylene ketal and its yield can reach 84.7%. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6Recommanded Product: 177-10-6).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Recommanded Product: 177-10-6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Binding of anti-Trypanosoma natural products from African flora against selected drug targets: a docking study was written by Ibezim, Akachukwu;Debnath, Biplab;Ntie-Kang, Fidele;Mbah, Chika John;Nwodo, Ngozi Justina. And the article was included in Medicinal Chemistry Research in 2017.Computed Properties of C8H14O2 This article mentions the following:

Recent publications have suggested that African medicinal plants and their derived products could be viable source of new and better trypanocidal drugs. Nowadays, in silico methods are often used in drug discovery processes to identify new potential drug leads. In this study, the authors have developed a small library named Afrotryp, comprising three-dimensional chem. structures of potential trypanocidal compounds derived from medicinal plants in Africa (a total of 321 unique chem. structures). The authors have predicted the pharmacokinetic properties of the library using Qikprop software and employed the three docking/scoring methods implemented in Mol. Operating Environment Dock Tool to assess the affinity of the library dataset towards the binding site of six selected validated anti-Trypanosoma drug targets. It was observed that about 42% of the compounds contained in the Afrotryp dataset were predicted to show a good overall performance in terms of predicted parameters for absorption, distribution, metabolism, elimination and toxicity properties. Docking calculations identified 15 compounds with lowest theor. binding energies toward the studied proteins, nine of which are suited for the treatment of stage 2 human African trypanosomiasis, due to their low polar surface area. Anal. of their binding modes gave basis for the observed unique mol. interactions which exist between the Afrotryp dataset and the six studied drug targets. The results lay the foundations for the rational development of novel trypanocidal drugs with improved potency. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6Computed Properties of C8H14O2).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Computed Properties of C8H14O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Chemical composition and biological activity of the volatile oils of Hyptis spicigera against Trypanosoma brucei brucei, (Tbb) found in Northern Nigeria was written by Ladan, Z.;Amupitan, J. O.;Oyewale, O. A.;Okonkwo, E. M.;Ladan, E. O.;Odjobo, B.;Habila, N.. And the article was included in African Journal of Pure and Applied Chemistry in 2011.COA of Formula: C8H14O2 This article mentions the following:

The hydrodistillation of the fresh leaves of Hyptis spicigera gave a colorless volatile oil with yield of 0.65%. The volatile oil gave forty compounds on the basis of gas chromatog.-mass spectroscopy (GC-MS) with low composition of cineole (4.11%) and caryophyllene (2.61%) while α-pinene (12.16%) β-pinene (9.47%) and α-phellandrene (10.19%) were predominant compounds The biol. activity of the volatile oils was evaluated in vitro for activity against Trypanosoma brucei brucei (Tbb) and was found to possess anti-trypanosoma activity in vitro in a dose dependent pattern at 0.5 μg/mL in 6 min. This activity showed the volatile oils from H. spicigera leaves to be a potential trypanocide. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6COA of Formula: C8H14O2).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.COA of Formula: C8H14O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and evaluation of analogs of 5′-(((Z)-4-amino-2-butenyl)methylamino)-5′-deoxyadenosine (MDL 73811, or AbeAdo) – An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity was written by Brockway, Anthony J.;Volkov, Oleg A.;Cosner, Casey C.;MacMillan, Karen S.;Wring, Stephen A.;Richardson, Thomas E.;Peel, Michael;Phillips, Margaret A.;De Brabander, Jef K.. And the article was included in Bioorganic & Medicinal Chemistry in 2017.Application of 177-10-6 This article mentions the following:

We describe our efforts to improve the pharmacokinetic properties of a mechanism-based suicide inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (AdoMetDC), essential for the survival of the eukaryotic parasite Trypanosoma brucei responsible for Human African Trypanosomiasis (HAT). The lead compound, 5′-(((Z)-4-amino-2-butenyl)methylamino)-5′-deoxyadenosine (1, also known as MDL 73811, or AbeAdo), has curative efficacy at a low dosage in a hemolymphatic model of HAT but displayed no demonstrable effect in a mouse model of the CNS stage of HAT due to poor blood-brain barrier permeation. Therefore, we prepared and evaluated an extensive set of analogs with modifications in the aminobutenyl side chain, the 5′-amine, the ribose, and the purine fragments. Although we gained valuable structure-activity insights from this comprehensive dataset, we did not gain traction on improving the prospects for CNS penetration while retaining the potent antiparasitic activity and metabolic stability of the lead compound 1. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6Application of 177-10-6).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Application of 177-10-6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Binding of anti-Trypanosoma natural products from African flora against selected drug targets: a docking study was written by Ibezim, Akachukwu;Debnath, Biplab;Ntie-Kang, Fidele;Mbah, Chika John;Nwodo, Ngozi Justina. And the article was included in Medicinal Chemistry Research in 2017.Computed Properties of C8H14O2 This article mentions the following:

Recent publications have suggested that African medicinal plants and their derived products could be viable source of new and better trypanocidal drugs. Nowadays, in silico methods are often used in drug discovery processes to identify new potential drug leads. In this study, the authors have developed a small library named Afrotryp, comprising three-dimensional chem. structures of potential trypanocidal compounds derived from medicinal plants in Africa (a total of 321 unique chem. structures). The authors have predicted the pharmacokinetic properties of the library using Qikprop software and employed the three docking/scoring methods implemented in Mol. Operating Environment Dock Tool to assess the affinity of the library dataset towards the binding site of six selected validated anti-Trypanosoma drug targets. It was observed that about 42% of the compounds contained in the Afrotryp dataset were predicted to show a good overall performance in terms of predicted parameters for absorption, distribution, metabolism, elimination and toxicity properties. Docking calculations identified 15 compounds with lowest theor. binding energies toward the studied proteins, nine of which are suited for the treatment of stage 2 human African trypanosomiasis, due to their low polar surface area. Anal. of their binding modes gave basis for the observed unique mol. interactions which exist between the Afrotryp dataset and the six studied drug targets. The results lay the foundations for the rational development of novel trypanocidal drugs with improved potency. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6Computed Properties of C8H14O2).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Computed Properties of C8H14O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Chemical composition and biological activity of the volatile oils of Hyptis spicigera against Trypanosoma brucei brucei, (Tbb) found in Northern Nigeria was written by Ladan, Z.;Amupitan, J. O.;Oyewale, O. A.;Okonkwo, E. M.;Ladan, E. O.;Odjobo, B.;Habila, N.. And the article was included in African Journal of Pure and Applied Chemistry in 2011.COA of Formula: C8H14O2 This article mentions the following:

The hydrodistillation of the fresh leaves of Hyptis spicigera gave a colorless volatile oil with yield of 0.65%. The volatile oil gave forty compounds on the basis of gas chromatog.-mass spectroscopy (GC-MS) with low composition of cineole (4.11%) and caryophyllene (2.61%) while α-pinene (12.16%) β-pinene (9.47%) and α-phellandrene (10.19%) were predominant compounds The biol. activity of the volatile oils was evaluated in vitro for activity against Trypanosoma brucei brucei (Tbb) and was found to possess anti-trypanosoma activity in vitro in a dose dependent pattern at 0.5 μg/mL in 6 min. This activity showed the volatile oils from H. spicigera leaves to be a potential trypanocide. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6COA of Formula: C8H14O2).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.COA of Formula: C8H14O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Catalytic synthesis of cyclohexanone ethylene ketal with solid superacid SO₄^2-/ZrO₂ was written by Wang, Junli;Meng, Shuangming;Guo, Yong;Zhao, Qiang;Fan, Yueqin. And the article was included in Huagong Keji in 2009.Recommanded Product: 177-10-6 This article mentions the following:

The solid superacid SO₄^2-/ZrO₂ catalyst was prepared and used for the synthesis of cyclohexanone ethylene ketal by ketal reaction. The effect of molar ratio of cyclohexanone to ethylene glycol, reaction time, catalyst amount, amount of the water-entraining agent and calcination temperature on the ketal reaction had been investigated. The optimum conditions are as follows: molar ratio of cyclohexanone to ethylene glycol is 1:1.5, the quantity of catalyst is equal to 0.5% of feed stock, cyclohexane is used as water-entraining agent, and reaction time is 60 min, solid superacid SO₄^2-/ZrO₂ is a good catalyst for synthesizing cyclohexanone ethylene ketal and its yield can reach 84.7%. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6Recommanded Product: 177-10-6).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Recommanded Product: 177-10-6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and catalytic activity of a Strandberg-type molybdophosphate modified by organic cations was written by Liu, Zhaoyu;Zhu, Haotian;Lu, Mingda;Li, Xiaohui;An, Yue;Zhang, Lancui. And the article was included in Yingyong Huaxue in 2015.Quality Control of 1,4-Dioxaspiro[4.5]decane This article mentions the following:

A Strandberg-type molybdophosphate {H₄(H₂biim)₅(C(NH₂)₃)₄} [H₂P₂Mo₅O₂₃]₂ · 8H₂O (1, H₂biim = 2,2′-biimidazole) modified by 2,2′-biimidazole and guanidinium cations was self-assembled in aqueous solution of pH = 3-4 containing sodium molybdate, 2,2′-biimidazole, guanidine hydrochloride and an excess of phosphoric acid, and was characterized by single crystal X-ray diffraction anal., IR spectroscopy (FT-IR), themogravimetry-DTA (TG-DTA) and X-ray powder diffraction (XRD). Compound 1 has a stable 3D organic-inorganic hybrid framework. It was used as a catalyst for carbonyl-protection. The synthesis of cyclohexanone ethylene ketal was performed as an example to investigate some influence factors on the yield, such as catalyst loading, molar ratio of reactants and reaction time. The optimal conditions are: the molar ratio of catalyst (based on Mo) to ketone is 1:300, the molar ratio of ketone to alc. is 1:1.4, and reaction time is 2.5 h. The catalytic activity of compound 1 for the synthesis of four other ketals was evaluated. The results show that compound 1 is a better catalyst for the synthesis of cyclohexanone ethylene ketal. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6Quality Control of 1,4-Dioxaspiro[4.5]decane).

1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Quality Control of 1,4-Dioxaspiro[4.5]decane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem