Tag: 116.1583

Organocatalytic enantioselective conjugate addition of 2-nitrocyclohexanone to acrylaldehyde: a concise two-step synthesis of chiral building block 1-azaspiro[4.5]decan-6-one was written by Ding, Xiao-Hua;Cui, Wei-Chen;Li, Xiang;Ju, Xuan;Liu, Dan;Wang, Shaozhong;Yao, Zhu-Jun. And the article was included in Tetrahedron Letters in 2013.Recommanded Product: 126-39-6 This article mentions the following:

A gram-scale organocatalytic enantioselective Michael addition of α-nitrocyclohexanone to acrolein has been developed, and it was successfully applied to a concise two-step synthesis of (1S)-azaspiro[4.5]decan-6-one I, a useful chiral building block for the synthesis of a variety of natural alkaloids. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Recommanded Product: 126-39-6).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: 126-39-6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Preparation and catalytic activity of SO₄^2-/TiO₂-WO₃ was written by Yang, Shui-Jin;Bai, Ai-Min;Yu, Xie-Qing;Sun, Ju-Tang. And the article was included in Youji Huaxue in 2004.Formula: C6H12O2 This article mentions the following:

A novel solid superacid catalyst, SO₄^2-/TiO₂-WO₃, was prepared Its catalytic activity for twelve important ketals and acetals was measured with esterification of butyric acid with Bu alc. as probing reaction. The preparation conditions of SO₄^2-/TiO₂-WO₃ have also been investigated, i.e., the mass ratio of the H₂WO₄ used in the compound is 12.5%, the calcining temperature is 580°, the calcining time is 3 h, and the soaked consistency of H₂SO₄ is 1.0 mol/L^-1. Exptl. results showed that S0₄^2-/TiO₂-WO₃ is an excellent catalyst for the synthesis of twelve important ketals and acetals. The optimum reaction conditions are that the molar ratio of aldehyde/ketone to glycol is 1:1.5, the mass ratio of the catalyst used in the reactants is 0.5%, and the reaction time is 1.0 h. Under these conditions, the yield of 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane is 78.7%, 2,4-dimethyl-2-ethoxycarbonylmethyl-1,3-dioxolane 83.0%, cyclohexanone ethylene ketal 85.9%, cyclohexanone 1,2-propanediol ketal 84.6%, butanone ethylene ketal 70.7%, butanone 1,2-propanediol ketal 88.3%, 2-propyl-1,3-dioxolane 80.6%, 4-methyl-2-propyl-1,3-dioxolane 79.6%, 2-isopropyl-1,3-dioxolane 64.2%, 4-methyl-2-isopropyl-1,3-dioxolane 83.3%, 2-phenyl-1,3-dioxolane 75.3%, 4-methyl-2-phenyl-1,3-dioxolane 95.1%, resp. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Formula: C6H12O2).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Formula: C6H12O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of acetals or ketals via acetalization or ketalization of aldehydes or ketones with glycols using titania-supported molybdotungstophosphoric acid (H₃Mo₆PW₆O₄₀) as catalyst was written by Yang, Shuijin;Tong, Wenlong. And the article was included in Xiyou Jinshu Cailiao Yu Gongcheng in 2007.Category: dioxole This article mentions the following:

A new environmentally friendly catalyst, H₃PW₆Mo₆O₄₀/TiO₂ is reported here. Optimized reaction conditions involved: mass ratio of m(TiO₂):m(H₃PW₆Mo₆O₄₀) 1/2.0, volume of water 30 mL, the reflux reaction time 2 h, activated temperature 150°. H₃PW₆Mo₆O₄₀/TiO₂ was used as catalyst in the synthesis of acetals and ketals, namely cyclohexanone ethylene ketal (i.e., 1,4-dioxaspiro[4.5]decane), cyclohexanone 1,2-propanediol ketal, butanone ethylene ketal, butanone 1,2-propanediol ketal, 2-phenyl-1,3-dioxolane, 4-methyl-2-phenyl-1,3-dioxolane, 2-propyl-1,3-dioxolane, 4-methyl-2-propyl-1,3-dioxolane. Effects of n(aldehyde/ketone):n(glycol), catalyst dosage and reaction time on yield were investigated. Optimized reaction conditions were: n(aldehyde/ketone):n(glycol) = 1.0:1.4; mass fraction of catalyst to reactants, 0.8%; reaction time, 1.0 h and cyclohexane as water-stripping reagent, 10 mL. Under these conditions, yield of cyclohexanone ethylene ketal, cyclohexanone 1,2-propanediol ketal, butanone ethylene ketal, butanone 1,2-propanediol ketal, 2-phenyl-1,3-dioxolane, 4-methyl-2-phenyl-1,3-dioxolane, 2-propyl-1,3-dioxolane and 4-methyl-2-propyl-1,3-dioxolane were 81.3%, 86.9%, 53.0%, 66.9%, 72.3%, 79.0%, 66.8%, 76.9% resp. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Category: dioxole).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Control of the Dual Reactivity (Iminium-Dienamine) of β-Arylmethyl α,β-Unsaturated Aldehydes in Organocatalytic 1,3-Dipolar Cycloadditions with N-Benzoyl C,N-Cyclic Azomethine Imines was written by Izquierdo, Cristina;Esteban, Francisco;Parra, Alejandro;Alfaro, Ricardo;Aleman, Jose;Fraile, Alberto;Ruano, Jose Luis Garcia. And the article was included in Journal of Organic Chemistry in 2014.Name: 2-Ethyl-2-methyl-1,3-dioxolane This article mentions the following:

1,3-Dipolar cycloadditions of C,N-cyclic azomethine imines with α,β-unsaturated aldehydes can be performed with complete control of the regio-, exo-, and enantioselectivity under aminocatalytic conditions. The so far never studied competence of the iminium-dienamine reactivity inherent to β-alkyl α,β-unsaturated aldehydes was studied, which was possible by allowing achievement of complete control of the chemoselectivity in reactions of the β-arylmethyl derivatives with azomethine imines by using different additives and organocatalysts, whose role was rationalized by DFT calculations and chem. proofs. Thus, it was possible to selectively obtain the pyrazolidines resulting from both the attack to the C2-C3 (via iminium) and the C3-C4 (via dienamine) bonds at the starting enals, which can be used as precursors of interesting tetrahydroisoquinolinic compounds In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Name: 2-Ethyl-2-methyl-1,3-dioxolane).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Name: 2-Ethyl-2-methyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

A simple approach to the preparation of H₆P₂W₁₈O₆₂/Cu₃(BTC)₂ (BTC = 1,3,5-benzenetricarboxylate) and its catalytic performance in the synthesis of acetals/ketals was written by Liu, Xiaoxia;Luo, Jing;Sun, Tingquan;Yang, Shuijin. And the article was included in Reaction Kinetics, Mechanisms and Catalysis in 2015.Synthetic Route of C6H12O2 This article mentions the following:

H₆P₂W₁₈O₆₂/Cu₃(BTC)₂ (BTC = 1,3,5-benzenetricarboxylate) as a new catalyst was prepared by the impregnation method and used to synthesize cyclohexanone ethylene ketal as a probe reaction, which has shown its favorable catalytic activity. FT-IR, XRD, SEM, N₂ adsorption-desorption isotherms and TG/DTA were used to characterize its composition, structure, morphol., stability and toleration for thermal in order to further prepare the catalyst with effective performance. Moreover, we have also explored the optimized conditions of carrying out the probe reaction by orthogonal experiments The optimized conditions were as follows: fixing cyclohexanone consumption was 0.02 mol, n(cyclohexanone):n(ethylene glycol) = 1:1.3, the mass ratio of the catalyst to total reactant was 0.2 %, cyclohexane dosage was 4 mL, and the reaction time was 75 min. The yield of the acetals and ketones could reach 54.9 ∼ 83.5 % under the optimum conditions. In addition, H₆P₂W₁₈O₆₂/Cu₃(BTC)₂ exhibited good reusability and the approaches above may enable rational design of advanced and environmental-friendly MOF-based catalysts. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Synthetic Route of C6H12O2).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Synthetic Route of C6H12O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Preparation and catalytic activity of SO₄^2-/TiO₂-WO₃ was written by Yang, Shui-Jin;Bai, Ai-Min;Yu, Xie-Qing;Sun, Ju-Tang. And the article was included in Youji Huaxue in 2004.Formula: C6H12O2 This article mentions the following:

A novel solid superacid catalyst, SO₄^2-/TiO₂-WO₃, was prepared Its catalytic activity for twelve important ketals and acetals was measured with esterification of butyric acid with Bu alc. as probing reaction. The preparation conditions of SO₄^2-/TiO₂-WO₃ have also been investigated, i.e., the mass ratio of the H₂WO₄ used in the compound is 12.5%, the calcining temperature is 580°, the calcining time is 3 h, and the soaked consistency of H₂SO₄ is 1.0 mol/L^-1. Exptl. results showed that S0₄^2-/TiO₂-WO₃ is an excellent catalyst for the synthesis of twelve important ketals and acetals. The optimum reaction conditions are that the molar ratio of aldehyde/ketone to glycol is 1:1.5, the mass ratio of the catalyst used in the reactants is 0.5%, and the reaction time is 1.0 h. Under these conditions, the yield of 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane is 78.7%, 2,4-dimethyl-2-ethoxycarbonylmethyl-1,3-dioxolane 83.0%, cyclohexanone ethylene ketal 85.9%, cyclohexanone 1,2-propanediol ketal 84.6%, butanone ethylene ketal 70.7%, butanone 1,2-propanediol ketal 88.3%, 2-propyl-1,3-dioxolane 80.6%, 4-methyl-2-propyl-1,3-dioxolane 79.6%, 2-isopropyl-1,3-dioxolane 64.2%, 4-methyl-2-isopropyl-1,3-dioxolane 83.3%, 2-phenyl-1,3-dioxolane 75.3%, 4-methyl-2-phenyl-1,3-dioxolane 95.1%, resp. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Formula: C6H12O2).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Formula: C6H12O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Organocatalytic enantioselective conjugate addition of 2-nitrocyclohexanone to acrylaldehyde: a concise two-step synthesis of chiral building block 1-azaspiro[4.5]decan-6-one was written by Ding, Xiao-Hua;Cui, Wei-Chen;Li, Xiang;Ju, Xuan;Liu, Dan;Wang, Shaozhong;Yao, Zhu-Jun. And the article was included in Tetrahedron Letters in 2013.Recommanded Product: 126-39-6 This article mentions the following:

A gram-scale organocatalytic enantioselective Michael addition of α-nitrocyclohexanone to acrolein has been developed, and it was successfully applied to a concise two-step synthesis of (1S)-azaspiro[4.5]decan-6-one I, a useful chiral building block for the synthesis of a variety of natural alkaloids. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Recommanded Product: 126-39-6).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: 126-39-6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of acetals or ketals via acetalization or ketalization of aldehydes or ketones with glycols using titania-supported molybdotungstophosphoric acid (H₃Mo₆PW₆O₄₀) as catalyst was written by Yang, Shuijin;Tong, Wenlong. And the article was included in Xiyou Jinshu Cailiao Yu Gongcheng in 2007.Category: dioxole This article mentions the following:

A new environmentally friendly catalyst, H₃PW₆Mo₆O₄₀/TiO₂ is reported here. Optimized reaction conditions involved: mass ratio of m(TiO₂):m(H₃PW₆Mo₆O₄₀) 1/2.0, volume of water 30 mL, the reflux reaction time 2 h, activated temperature 150°. H₃PW₆Mo₆O₄₀/TiO₂ was used as catalyst in the synthesis of acetals and ketals, namely cyclohexanone ethylene ketal (i.e., 1,4-dioxaspiro[4.5]decane), cyclohexanone 1,2-propanediol ketal, butanone ethylene ketal, butanone 1,2-propanediol ketal, 2-phenyl-1,3-dioxolane, 4-methyl-2-phenyl-1,3-dioxolane, 2-propyl-1,3-dioxolane, 4-methyl-2-propyl-1,3-dioxolane. Effects of n(aldehyde/ketone):n(glycol), catalyst dosage and reaction time on yield were investigated. Optimized reaction conditions were: n(aldehyde/ketone):n(glycol) = 1.0:1.4; mass fraction of catalyst to reactants, 0.8%; reaction time, 1.0 h and cyclohexane as water-stripping reagent, 10 mL. Under these conditions, yield of cyclohexanone ethylene ketal, cyclohexanone 1,2-propanediol ketal, butanone ethylene ketal, butanone 1,2-propanediol ketal, 2-phenyl-1,3-dioxolane, 4-methyl-2-phenyl-1,3-dioxolane, 2-propyl-1,3-dioxolane and 4-methyl-2-propyl-1,3-dioxolane were 81.3%, 86.9%, 53.0%, 66.9%, 72.3%, 79.0%, 66.8%, 76.9% resp. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Category: dioxole).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Control of the Dual Reactivity (Iminium-Dienamine) of β-Arylmethyl α,β-Unsaturated Aldehydes in Organocatalytic 1,3-Dipolar Cycloadditions with N-Benzoyl C,N-Cyclic Azomethine Imines was written by Izquierdo, Cristina;Esteban, Francisco;Parra, Alejandro;Alfaro, Ricardo;Aleman, Jose;Fraile, Alberto;Ruano, Jose Luis Garcia. And the article was included in Journal of Organic Chemistry in 2014.Name: 2-Ethyl-2-methyl-1,3-dioxolane This article mentions the following:

1,3-Dipolar cycloadditions of C,N-cyclic azomethine imines with α,β-unsaturated aldehydes can be performed with complete control of the regio-, exo-, and enantioselectivity under aminocatalytic conditions. The so far never studied competence of the iminium-dienamine reactivity inherent to β-alkyl α,β-unsaturated aldehydes was studied, which was possible by allowing achievement of complete control of the chemoselectivity in reactions of the β-arylmethyl derivatives with azomethine imines by using different additives and organocatalysts, whose role was rationalized by DFT calculations and chem. proofs. Thus, it was possible to selectively obtain the pyrazolidines resulting from both the attack to the C2-C3 (via iminium) and the C3-C4 (via dienamine) bonds at the starting enals, which can be used as precursors of interesting tetrahydroisoquinolinic compounds In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Name: 2-Ethyl-2-methyl-1,3-dioxolane).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Name: 2-Ethyl-2-methyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

A simple approach to the preparation of H₆P₂W₁₈O₆₂/Cu₃(BTC)₂ (BTC = 1,3,5-benzenetricarboxylate) and its catalytic performance in the synthesis of acetals/ketals was written by Liu, Xiaoxia;Luo, Jing;Sun, Tingquan;Yang, Shuijin. And the article was included in Reaction Kinetics, Mechanisms and Catalysis in 2015.Synthetic Route of C6H12O2 This article mentions the following:

H₆P₂W₁₈O₆₂/Cu₃(BTC)₂ (BTC = 1,3,5-benzenetricarboxylate) as a new catalyst was prepared by the impregnation method and used to synthesize cyclohexanone ethylene ketal as a probe reaction, which has shown its favorable catalytic activity. FT-IR, XRD, SEM, N₂ adsorption-desorption isotherms and TG/DTA were used to characterize its composition, structure, morphol., stability and toleration for thermal in order to further prepare the catalyst with effective performance. Moreover, we have also explored the optimized conditions of carrying out the probe reaction by orthogonal experiments The optimized conditions were as follows: fixing cyclohexanone consumption was 0.02 mol, n(cyclohexanone):n(ethylene glycol) = 1:1.3, the mass ratio of the catalyst to total reactant was 0.2 %, cyclohexane dosage was 4 mL, and the reaction time was 75 min. The yield of the acetals and ketones could reach 54.9 ∼ 83.5 % under the optimum conditions. In addition, H₆P₂W₁₈O₆₂/Cu₃(BTC)₂ exhibited good reusability and the approaches above may enable rational design of advanced and environmental-friendly MOF-based catalysts. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Synthetic Route of C6H12O2).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Synthetic Route of C6H12O2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem