Tag: 100-200

Catalytic synthesis of acetals and ketals with iodine was written by Yang, Shuijin;Tong, Wenlong. And the article was included in Xiangliao Xiangjing Huazhuangpin in 2006.Synthetic Route of C8H14O4 The following contents are mentioned in the article:

Catalytic activities of Iodine in synthesizing 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane, 2,4-dimethyl-2-ethoxycarbonylmethyl-1,3-dioxolane, cyclohexanone ethylene ketal, cyclohexanone 1,2-propanediol ketal, butanone ethylene ketal, butanone 1,2-propanediol ketal, 2-phenyl-1,3-dioxolane, 4-methyl-2-phenyl-1,3-dioxolane, 2-propyl-1,3-dioxolane, 4-methyl-2-propyl-1,3-dioxolane were reported. It was demonstrated that Iodine was an excellent catalyst. Various factors concerned in these reactions were investigated. The optimum conditions were found, that was, the molar ratio of aldehyde/ketone to glycol was 1/1.3, the mass ratio of the catalyst used to the reactant s was 0.4%, and the reaction time was 40-60 min. Under these conditions, the yield of 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane was 63.8%, and 2,4-dimethyl-2-ethoxycarbonylmethyl-1,3-dioxolane was 70.7%, the yield of cyclohexanone ethylene ketal was 85.9%, and cyclohexanone 1,2-propanediol ketal was 88.8%, the yield of butanone ethylene ketal was 45.2%, and butanone 1,2-propanediol ketal was 86.9%, the yield of 2-phenyl-1,3-dioxolane was 80.3%, and 4-methyl-2-phenyl-1,3-dioxolane was 86.3%, the yield of 2-propyl-1,3-dioxolane was 83.6%, and 4-methyl-2-propyl-1,3-dioxolane was 91.2%. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Synthetic Route of C8H14O4).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Synthetic Route of C8H14O4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Amidation Reactions from the Direct Coupling of Metal Carboxylate Salts with Amines was written by Goodreid, Jordan D.;Duspara, Petar A.;Bosch, Caroline;Batey, Robert A.. And the article was included in Journal of Organic Chemistry in 2014.Related Products of 6413-10-1 The following contents are mentioned in the article:

A general method for the synthesis of amides involving the direct coupling of alkali metal carboxylate salts with amines is described. Amidation of a wide variety of carboxylate salts with either free amines or their ammonium hydrochloride salts can be achieved using HBTU as a coupling agent in combination with Huenig’s base. The reaction is highly efficient and is generally complete in as little as 1-2 h, giving the products in good to excellent yields. The protocol is valuable for the coupling of carboxylates for which the corresponding carboxylic acids or acyl chlorides are unstable, less conveniently manipulated/isolated, or are not com. available. For example, the coupling of amines and α-amino acids with lithium 5-bromo-1H-pyrrole-2-carboxylate, whose corresponding acid that is prone to decarboxylation, allowed for the synthesis of 5-bromo-1H-pyrrole-2-carboxamides, which are analogs of the pyrrole-2-aminoimidazole marine alkaloids. The protocol can be combined with other reactions in a sequenced fashion, as exemplified by the synthesis of acetylenic amides, in a one-pot procedure, via the coupling of a lithium carboxylate salt formed initially by the addition of carbon dioxide to a lithiated terminal alkyne. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Related Products of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Related Products of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Total synthesis and anti-inflammatory evaluation of violacin A and its analogues was written by Liu, Qingyin;Mu, Yu;An, Qi;Xun, Jiali;Ma, Jian;Wu, Wenxi;Xu, Minjuan;Xu, Jun;Han, Li;Huang, Xueshi. And the article was included in Bioorganic Chemistry in 2020.Application In Synthesis of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate The following contents are mentioned in the article:

A concise total synthesis of an exceedingly potent anti-inflammatory agent violacin A (I) as well as the preparation of thirty analogs of this lead from com. available orcinol are described. Highlights of our synthetic efforts involve Friedel-Crafts acylation, the regioselective etherification and esterification of phenolic hydroxyl groups, and Baker-Venkataraman rearrangement to form basic skeleton of violacin A. The deprotection reaction with Pd-catalytic was involved to avoid the elimination of the hemiacetal hydroxyl at C2. In addition, all synthetic compounds were screened for anti-inflammatory activity against nitric oxide (NO) production using lipopolysaccharide (LPS)-induced Raw264.7 cells. A range of violacin A derivatives II – V [R = Me, (un)substituted benzyl] exhibited stronger anti-inflammatory effect than that of violacin A. Notably, halogeno-benzyloxy substituent at C-7 were favorable for anti-inflammatory activities of violacin A derivatives Addnl., Western blot results indicated halogeno-benzyloxy derivatives inhibited pro-inflammatory cytokines releases correlated with the suppression of NF-κB signaling pathway. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Application In Synthesis of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Catalytic behavior of SBA-15 supported heteropoly compounds in synthesis of fructone was written by Zhang, Fu-min;Yuan, Chao-shu;Wang, Jun. And the article was included in Gaoxiao Huaxue Gongcheng Xuebao in 2006.Formula: C8H14O4 The following contents are mentioned in the article:

Catalysts of 12-tungstophosphoric acid (PW), cesium salt of PW and potassium salt of PW supported on mesoporous silica SBA-15 with different loadings were prepared by impregnation, resp. Their catalytic behaviors were investigated via the acetalization of Et acetoacetate with ethylene glycol to synthesize fructone. The phys. and chem. properties of the catalysts prepared were characterized by N₂ adsorption, Hammett indicator and FT-IR. The catalytic stability of the catalysts was evaluated by water treatment test, in which the concentration of the heteropoly compound leaking into the water was measured by UV-visual spectrophotometer. It is found that the catalysts have no activity in the synthesis of fructone when the loading of PW on SBA-15 is lower than 30% and the loading of Cs salt or K salt of PW on SBA-15 is lower than 20%. During repeatedly using, the deactivation of the catalysts prepared is closely associated with the leakage of active heteropoly species into the polar solvent. Since in the polar reaction system, the cesium salts of PW are water-tolerant, it causes the catalyst of supported cesium salts of PW on SBA-15 has higher catalytic stability. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Formula: C8H14O4).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Formula: C8H14O4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem