Tag: 100-200

Selective, Orally Active 5-HT_1D Receptor Agonists as Potential Antimigraine Agents was written by MacLeod, Angus M.;Street, Leslie J.;Reeve, Austin;Jelley, Richard A.;Sternfeld, Francine;Beer, Margaret S.;Stanton, Josephine A.;Watt, Alan P.;Rathbone, Denise;Matassa, Victor G.. And the article was included in Journal of Medicinal Chemistry in 1997.Category: dioxole This article mentions the following:

The clin. effective antimigraine drug, sumatriptan, is a serotonin receptor agonist with equal affinity for the 5-HT_1B and 5-HT_1D subtypes. To determine whether a compound selective for the 5-HT_1D subtype would have the same clin. efficacy, but with reduced side effects, a structural exploration of non-selective compounds was carried out to identify features that would provide differential binding affinity for the two receptors. Functionalized piperazinylpropylindoles were shown to have high affinity for 5-HT_1D with binding selectivities greater than 100-fold with respect to 5-HT_1B. The meta-fluorophenethylpiperazine L-775,606 was highlighted as the first orally bioavailable, selective 5-HT_1D agonist. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Category: dioxole).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

New masked δ-lithio carbonyl compounds: preparation and synthetic applications was written by Gil, Juan F.;Ramon, Diego J.;Yus, Miguel. And the article was included in Tetrahedron in 1993.Recommanded Product: 118336-86-0 This article mentions the following:

The reaction of 2-(4-chlorobutyl)-1,3-dioxolanes I (R = H, Et, Ph; R¹ = Cl) or 2-(4-chlorobutyl)-2-ethyl-1,3-dithiane with an excess of lithium powder and a catalytic amount of naphthalene (8 mol %) in THF at -78° leads to a solution of the corresponding masked lithium δ-enolates, which react with different electrophiles (water, deuterium oxide, carbonyl compounds, carboxylic acid derivatives, dibenzyl disulfide or benzylideneaniline) to yield the expected products, e.g., I [R = H, R¹ = H, D, PhCH(OH), PhCH₂S]. In the presence of a catalytic amount of CuBr.Me₂S, the intermediate I (R = H, R¹ = Li) reacts with cyclohex-2-enone giving the compound I (R = H, R¹ = 3-oxocyclohexyl) through a conjugate addition The deprotection of the dioxolane moiety with 2 N HCl gives the expected functionalized carbonyl compounds In situ generated hydroxy aldehydes react with triethylsilane, allyltrimethylsilane, and trimethylsilyl cyanide to give alcs. [e.g., Et₂CH(CH₂)₅OH], dienic alcs. [e.g., Me₂C:CH(CH₂)₃CH(OH)CH₂CH:CH₂], and cyanooxepanes II (R² = H, R³ = Ph; R² = R³ = Me, Et; R²R³ = (CH₂)₅]. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Recommanded Product: 118336-86-0).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Recommanded Product: 118336-86-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Polymer supported naphthalene-catalyzed lithiation reactions was written by Gomez, Cecilia;Ruiz, Sonia;Yus, Miguel. And the article was included in Tetrahedron Letters in 1998.Application of 118336-86-0 This article mentions the following:

The reaction of functionalized mono- or dichlorinated materials with an excess of lithium and a catalytic amount of a naphthalene-containing polymer (P-152, easily prepared by radical copolymerization of 2-vinylnaphthalene, styrene and divinylbenzene) in THF either in the presence (Barbier-type conditions) or absence of different electrophiles [Me₃SiCl, BuCHO, iso-BuCHO, PhCHO, Et₂CO, c(C₃H₅)₂CO, iso-Pr₂CO, (CH₂)₄CO, (CH₂)₅CO, PhCOMe, PhCH:NPh] leads, after hydrolysis, to the expected products. The catalyst is quant. recovered and can be reused several times without loss of activity. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Application of 118336-86-0).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Application of 118336-86-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Lithiation reactions catalyzed by linear and cross-linked arene-based polymers. Generation of functionalized organolithium compounds was written by Candela, P.;Gomez, C.;Yus, M.. And the article was included in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) in 2004.Computed Properties of C7H13ClO2 This article mentions the following:

Lithiation of various substrates, such as chlorinated acetals (e.g. 2-(4-chlorobutyl)-1,3-dioxolane), α-chloro ether, dichloro derivatives, benzo-fused heterocycles (e.g. isobenzofuran), and allyl and benzyl derivatives, with excess Li powder in the presence of a catalytic amount of soluble linear or insoluble cross-linked arene (naphthalene or biphenyl)-based polyolefins, yields the expected organolithium intermediates. The latter react with electrophiles (e.g. Et₂CO) either in two steps or under Barbier-type reaction conditions to afford the corresponding adducts. The catalyst is easily recuperated by filtration at the end of the process, and the procedure can be regarded as a reasonable alternative to the use of free arenes as electron carrier in lithiation reactions. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Computed Properties of C7H13ClO2).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Computed Properties of C7H13ClO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

m-Terphenyl ethers, a new hydroxy protecting group cleavable under reductive single electron transfer reaction conditions was written by Azzena, Ugo;Mocci, Sarah;Pisano, Luisa. And the article was included in Synthesis in 2011.Synthetic Route of C7H13ClO2 This article mentions the following:

2,6-Diphenylphenyl ethers and, to a lesser extent, 2,6-dimethoxyphenyl ethers, were tested as protected hydroxyl derivatives under a variety of reaction conditions. These ethers underwent regioselective cleavage of the aromatic C(1)-O bond under reductive SET reaction conditions using alkali metals in THF at room temperature This deprotective procedure was efficiently realized in the presence of several other functional groups, including an acetal, a Ph alkyl ether, an unprotected alc., and C-C double and triple bonds. Furthermore, meta-terphenyl ethers proved stable under different reaction conditions, including acidic hydrolysis and formation and/or employment of different organometallic reagents. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Synthetic Route of C7H13ClO2).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Synthetic Route of C7H13ClO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Polyphenylene as an electron transfer catalyst in lithiation processes was written by Yus, Miguel;Gomez, Cecilia;Candela, Pablo. And the article was included in Tetrahedron in 2002.Formula: C7H13ClO2 This article mentions the following:

The lithiation of different functionalized chlorinated materials, dichlorinated compounds and benzofused cyclic ethers with lithium powder in the presence of catalytic amounts of either linear (LPP) or crosslinked (CPP) polyphenylene, in THF at temperatures ranging between -78 and 20°C, leads to the expected organolithium intermediates, which by reaction with electrophiles [Bu^tCHO, PhCHO, Et₂CO, (CH₂)₅CO, PhCOMe, Me₃SiCl] gives, after hydrolysis with water, the expected products. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Formula: C7H13ClO2).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C7H13ClO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Dianion of N-phenyl-2-[(phenylsulfonyl)methyl]propenamide as a versatile reagent for the preparation of α-methylene carbonyl compounds was written by Tanaka, Kazuhiko;Horiuchi, Hiroshi;Yoda, Hidemi. And the article was included in Journal of Organic Chemistry in 1989.COA of Formula: C7H13ClO2 This article mentions the following:

A general synthetic route to α-methylene β-lactams involves the regioselective electrophilic substitution of the dianion generated from PhSO₂CH₂C(:CH₂)CONHPh (I). A convergent synthesis of conocandin N-phenylamide [(3R^*,4R^*)-II was carried out. Key steps in the synthesis are the stereoselective introduction of the C(9)-C(10) trisubstituted double bond of the amide using the dianion of I and the transformation of the sulfonyl group in the intermediate amide, (E)-9-hydroxy-10-methyl-2-methylene-N-phenyl-3-(phenylsulfonyl)-9-hexadecenamide, prepared from (E)-7-methyl-6-tridecenal and the dianion of I, into a hydroxy function via [2,3]-sigmatropic rearrangement of the selenoxide. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0COA of Formula: C7H13ClO2).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.COA of Formula: C7H13ClO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Dienediolates of unsaturated carboxylic acids in synthesis. Aldehydes and ketones from alkyl halides, by ozonolysis of β,γ-unsaturated α-alkyl carboxylic acids. The role of a tertiary amine in the cleavage of ozonides was written by Aurell, Maria Jose;Ceita, Luisa;Mestres, Ramon;Tortajada, Amparo. And the article was included in Tetrahedron in 1997.Formula: C7H13ClO2 This article mentions the following:

A convenient two-step procedure for a two carbon homologative conversion of alkyl halides into aldehydes and Me ketones by α-alkylation of unsaturated carboxylic acids, followed by ozonolysis is developed and applied to the synthesis of ω-chloro aldehydes. Triethylamine is superior to di-Me sulfide or triphenylphosphine for cleavage of the ozonides, except when aldol condensation side reactions require use of protic solvents and iodide salts. Cleavage of the ozonides by triethylamine is shown to occur mainly through a reductive process. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Formula: C7H13ClO2).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Formula: C7H13ClO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and structural characterization of lower rim halogenated pyrogallol[4]arenes: bi-layers and hexameric nano-capsules was written by Dalgarno, Scott J.;Power, Nicholas P.;Antesberger, Jochen;McKinlay, Robert M.;Atwood, Jerry L.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2006.Application In Synthesis of 2-(4-Chlorobutyl)-1,3-dioxolane This article mentions the following:

Two lower rim halogenated pyrogallol[4]arenes have been synthesized and structurally characterized as either bi-layer or hexameric nano-capsule motifs depending upon chain length and functionalization. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Application In Synthesis of 2-(4-Chlorobutyl)-1,3-dioxolane).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of 2-(4-Chlorobutyl)-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Polymer supported arene-catalyzed lithiation reactions was written by Gomez, Cecilia;Ruiz, Sonia;Yus, Miguel. And the article was included in Tetrahedron in 1999.Application In Synthesis of 2-(4-Chlorobutyl)-1,3-dioxolane This article mentions the following:

The reaction of functionalized chlorinated materials with an excess of lithium and a catalytic amount of a naphthalene (P_N) or biphenyl (P_B) supported polymer (easily prepared by radical copolymerization of 2-vinylnaphthalene or 4-vinylbiphenyl with vinylbenzene and divinylbenzene) in THF and electrophiles [Me₃SiCl, ⁱPrCHO, PhCHO, Et₂CO, (CH₂)₄CO, (CH₂)₅CO, (c-C₃H₅)₂CO, iPr₂CO, PhCOMe, PhCH=NPh] at -78 or -50°C leads, after hydrolysis with water, to the expected functionalized products. Such polymeric reagents were 2-ethenylnaphthalene polymer with ethenylbenzene and diethenylbenzene and 4-ethenyl-1,1′-biphenyl polymer with ethenylbenzene and diethenylbenzene. The polymeric catalyst is quant. recovered and can reused several times without any loss of activity. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Application In Synthesis of 2-(4-Chlorobutyl)-1,3-dioxolane).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Application In Synthesis of 2-(4-Chlorobutyl)-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem