Sugimura, Hideyuki et al. published their research in Tennen Yuki Kagobutsu Toronkai Koen Yoshishu in 1998 | CAS: 14131-84-1

Synthetic studies on guanofosfocins – synthesis of 8-(mannopyranosyloxy)adenosine derivatives was written by Sugimura, Hideyuki;Kanamori, Hideyuki;Stansfield, Kevin. And the article was included in Tennen Yuki Kagobutsu Toronkai Koen Yoshishu in 1998.Recommanded Product: (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol This article mentions the following:

Two approaches for the synthesis of 8-(glycosyloxy)purine nucleoside, which is found in a recently isolated chitin synthase inhibitor-guanofosfocin, have been examined One contains substitution reaction of alc. with purine nucleoside bearing a leaving group at the 8 position. Through a number of model reactions using cyclohexanol as a nucleophile and 8-substituted adenosine derivatives as a substrate, we finally found that N⁶-benzoyl-8-bromoadenosine derivative (I; R = Br, R¹ = Bz, R² = 4,4′-dimethoxytrityl) reacted with sodium alkoxides derived from di-O-isopropylidene-α-D-mannoses (Q-H and Q¹-H), in DMF at room temperature to yield 8-(mannosyloxy)adenosines (I; R = Q, R¹ = Bz) and (I; R = Q¹, R¹ = Bz) and in reasonable yields. Another approach involves glycosylation reaction of 8-oxoadenosine derivatives with appropriate mannosyl donors. We found that N⁶-trityl-adenosine derivative (II) was a suitable substrate for this reaction. When 2,3,4,6-tetra-O-benzyl-α-D-mannosyl bromide was allowed to react with 8-hydroxyadenosine derivative (II) in the presence of silver carbonate in toluene at 60°C, 8-(mannosyloxy)adenosine (I; R = Q², R¹ = R² = Tr) is obtained in 79% yield. The 8-mannosyloxy products were isolated solely as α anomers, assigned by ¹J_C-H value of C-1 in the mannose moiety. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Recommanded Product: (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem