Dahiya, Rajiv; Singh, Sunil; Gupta, Sheeba Varghese; Sutariya, Vijaykumar B.; Bhatia, Deepak; Mourya, Rita; Chennupati, Suresh V.; Sharma, Ajay published the article 《First total synthesis and pharmacological potential of a plant based hexacyclopeptide》. Keywords: Drymaria Pseudomonas Klebsiella Candida hexacyclopeptide antimicrobial antihelmintic agent; Antihelmintic activity; Antimicrobial activity; Diandrine C; Drymaria diandra; Proline-rich cyclic peptide; Solution-phase peptide synthesis.They researched the compound: H-Trp-OMe.HCl( cas:7524-52-9 ).Product Details of 7524-52-9. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:7524-52-9) here.
A new bioactive proline-rich cyclohexapeptide – diandrine C (6), previously isolated from whole plant of Drymaria diandra (Caryophyllaceae), was synthesized through coupling reactions of tetrapeptide unit Boc-Gly-L-Pro-L-Tyr-L-Trp-OH with dipeptide unit L-ProGly-OMe using N,N-diisopropylcarbodiimide (DIPC) as the coupling agent, followed by cyclization of linear hexapeptide unit under alk. condition. Structure of cyclohexapeptide was confirmed by means of chem., and spectroscopic analyses and also was screened for its antimicrobial and anthelmintic properties. Bioevaluation results indicated that the newly synthesized hexacyclopeptide exhibited potent antimicrobial activity against Gram-neg. bacteria Pseudomonas aeruginosa, Klebsiella pneumoniae and pathogenic Candida albicans at 6 μg/mL. Moderate to good level of antihelmintic activity against three earthworm species Megascoplex konkanensis, Pontoscotex corethruses and Eudrilus eugeniae was also observed at concentration of 2 mg/mL.
After consulting a lot of data, we found that this compound(7524-52-9)Product Details of 7524-52-9 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem