The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Preparation of phospho sugar analogs and their evaluation as novel anticancer agents, the main research direction is phospho sugar analog preparation anticancer leukemia.Related Products of 707-61-9.
Phospho sugars were prepared by a novel synthetic route starting from phosphorus heterocyclic compounds, 2-phospholenes. The anhydro- and deoxy-phospha sugar derivatives have been revealed to have potential anticancer activities against human leukemia K562 and U937 cell lines. In this article, deoxybromophospho sugars with different numbers of bromo substituents were prepared, and their anticancer activities were evaluated by MTT method. The order of the activities depending on the number of bromo substituent was first revealed, and trideoxytribromotetrofuranose type phospho sugar [2,3,4-tribromo-3-methyl-1-phenylphospholane 1-oxide (4: TBMPPAO)] was the most active among these phospha sugars prepared Diastereomers of dideoxydibromotetrofuranose-type phospho sugar [2,3-dibromo-3-methyl-1-phenylphospholane 1-oxide (2: DBMPPAO)] were separated into four components, and the structure as well as the character of each component was assigned by spectral and chromatog. data as well as by MTT method.The deoxybromophospha sugars have higher antileukemia activity than Gleevec against U937 cells.
Although many compounds look similar to this compound(707-61-9)Related Products of 707-61-9, numerous studies have shown that this compound(SMILES:CC1=CP(CC1)(C2=CC=CC=C2)=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem