Synthesis and Biological Characterization of a Series of 2-Sulfonamidebenzamides as Allosteric Modulators of MrgX1 was written by Sharma, Swagat;Peng, Qi;Vadukoot, Anish K.;Aretz, Christopher D.;Jensen, Aaron A.;Wallick, Alexander I.;Dong, Xinzhong;Hopkins, Corey R.. And the article was included in ACS Medicinal Chemistry Letters in 2022.Name: 2,2-Difluorobenzo[d][1,3]dioxol-5-amine This article mentions the following:
The present study describes the continued efforts in the discovery and characterization of a series of 2-sulfonamidebenzamides e.g., 3-(Cyclopropanesulfonamido)-N-(2-ethoxyphenyl)-2-naphthamide as allosteric modulators of MrgX1. MrgX1 has been shown to be an attractive target as a nonopioid receptor for the potential treatment of chronic pain. Working from the original compound, ML382, and utilizing iterative medicinal chem., key halogen substituents that improve MrgX1 potency by ~8-fold were identified. In addition, the compounds in Tier 1 drug metabolism and pharmacokinetics assays were evaluated and the key compounds that impart improved potency and microsomal stability were identified. In the experiment, the researchers used many compounds, for example, 2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0Name: 2,2-Difluorobenzo[d][1,3]dioxol-5-amine).
2,2-Difluorobenzo[d][1,3]dioxol-5-amine (cas: 1544-85-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Name: 2,2-Difluorobenzo[d][1,3]dioxol-5-amine
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem