144690-92-6, A common heterocyclic compound, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.”144690-92-6
(4) the C48 H44 N6 O6 AMST – 6, acetone, water, sulfuric acid added to the reactor, the temperature rising to 30 C reaction 2.5 hours, adding water, 30 C continue to reaction 1.5 hours or more, when the raw material to achwhich isve the requirement of lowering the temperature to 5 C stirring 1 or more hours, filtering the triphenyl methanol, the filter cake is washed with water; mother liquor up to 50 C, add sodium bicarbonate, stirring 1 hour, filtration products, the filter cake is washed with water, 50 C decompression drying 12 hours or more to constant weight, to obtain omay sha tanzhi thick; said C48 H44 N6 O6 AMST – 6, acetone, water, sulfuric acid and sodium bicarbonate and the mass ratio of 700:1400:: 2101.4: 194.7: 373.5; (5) the crude product of olmesartan medoxomil and acetone is added to the reaction in the bottle, heat to reflux to totally dissolve, filter press, distilling off acetone, lowering the temperature to -10 C crystallization, filtration, acetone washing, 50 C drying productC29 H30 N6 O6 Olmesartan medoxomil, the crude with olmesartan medoxomil mass ratio of olmesartan medoxomil 448.4: 6500;
With the complex challenges of chemical substances, we look forward to future research findings about Triphenyl methyl olmesartan,belong Dioxole compound
Reference£º
Patent; Jiangxi Yong Tong Technology Co., Ltd.; Liu Zhongchun; (10 pag.)CN107311989; (2017); A;,
1,3-Benzodioxole – Wikipedia
Dioxole | C3H4O2 – PubChem