On January 4, 2017, Shang, Debin published a patent.Synthetic Route of 38838-06-1 The title of the patent was Process for preparation of Ticagrelor key intermediate. And the patent contained the following:
The invention relates to a process for the preparation of Ticagrelor key intermediate 2-[[(3aR,4S,6R,6aS)-6-amino-tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol (key intermediate A). The method comprises methylation of 1-position of D-ribose and protection with acetone to obtain Me 2,3-O-isopropylidene-β-D-ribofuranoside, followed by reaction with tosyl chloride, iodination, ring opening, cyclization, reduction, protection with Cbz-Cl, reaction with Et bromoacetate, reduction, and deprotection. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Synthetic Route of 38838-06-1
The Article related to preparation ticagrelor key intermediate, Heterocyclic Compounds (More Than One Hetero Atom): Dioxoles, Oxathioles, Dithioles and other aspects.Synthetic Route of 38838-06-1
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem