Synthesis of (±)-Serralongamine A and the Revised Structure of Huperzine N was written by Saborit, Gisela V.;Bosch, Caroline;Parella, Teodor;Bradshaw, Ben;Bonjoch, Josep. And the article was included in Journal of Organic Chemistry in 2016.Synthetic Route of C6H12O2 This article mentions the following:
A revised structure for the Lycopodium alkaloid huperzine N,is proposed and confirmed by synthesis. The key synthetic steps involve an epimerization of a cis-5-oxodecahydroquinoline to the corresponding trans isomer and a coupling, followed by a diastereoselective hydrogenation using Wilkinson’s catalyst to incorporate the pyridylmethyl moiety. This route allowed the alkaloid serralongamine A, I, to be synthesized for the first time, and two addnl. steps led to the revised structure of huperzine N, II, both products bearing an unusual decahydroquinoline stereostructure. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Synthetic Route of C6H12O2).
2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Synthetic Route of C6H12O2
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem