Base-mediated Nitrophenyl Reductive Cyclization for the Synthesis of Hexahydro-2,6-methano-1-benzazocines was written by Rodriguez, Laura G.;Delgado, Ana;Ciudad, Carlos J.;Noe, Veronique;Bonjoch, Josep;Bradshaw, Ben. And the article was included in Journal of Organic Chemistry in 2022.SDS of cas: 126-39-6 This article mentions the following:
A Diels-Alder reaction leading to 4-nitrophenylcyclohexanones followed by a newly developed base-mediated reductive cyclization of the resulting ketone tethered to the nitrobenzene moiety gives access to the hexahydro-2,6-methano-1-benzazocine ring system present in several biol. interesting natural products such as aspernomine. The scope of the reaction was explored with eight substituted nitrobenzenes obtaining yields of up to 87%. The highest cytotoxicity was observed in benzazocine I, bearing an enone moiety, which was active against eight cancer cell lines. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6SDS of cas: 126-39-6).
2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.SDS of cas: 126-39-6
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem