An applied stereocontrolled synthesis of piperidine derivative utilizing diastereoselective reaction of chiral 1,3-oxazolidine with grignard reagent; asymmetric synthesis of an alkaloid, (-)-sedamine was written by Poerwono, Hadi;Higashiyama, Kimio;Takahashi, Hiroshi. And the article was included in Heterocycles in 1998.Product Details of 62563-07-9 This article mentions the following:
A facile total synthesis of enantiomerically pure (-)-sedamine (I), known as a naturally occurring alkaloid, was accomplished by use of the diastereoselective addition of Grignard reagent to a chiral 1,3-oxazolidine, and utilizing of 1-aza-4-oxabicyclo[4.3.0]nonane derivative II as a key intermediate. A diastereomeric pair, (-)-allosedamine, was also recovered as a minor product. In the experiment, the researchers used many compounds, for example, 2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9Product Details of 62563-07-9).
2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Product Details of 62563-07-9
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem