On April 30, 2001, Palmer, Andreas M.; Jager, Volker published an article.HPLC of Formula: 38838-06-1 The title of the article was Synthesis of glycosidase-inhibiting iminopolyols by Cope-House cyclization of unsaturated hydroxylamines. III. Pyrrolidine N-oxides by stereoselective addition of Grignard and lithium compounds to 4,5-dideoxy-2,3-O-isopropylidene-D-erythro-4-pentenose N-benzylnitrone and subsequent Cope-House cyclization. And the article contained the following:
The addition of Grignard reagents to D-erythro-4-pentenose N-benzylnitrone, which is easily accessible from D-ribose, furnishes ω-unsaturated hydroxylamines that readily undergo Cope-House cyclization to afford pyrrolidine N-oxides. The stereoselectivity of the addition step is altered by either employing organolithium compounds or Lewis acids as complexing agents. The pyrrolidine N-oxides obtained by this sequence serve as key intermediates in the synthesis of 2,5-disubstituted pyrrolidine-3,4-diols, both constituting new potential inhibitors of glycosidases. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).HPLC of Formula: 38838-06-1
The Article related to pyrrolidine oxide derivative stereoselective preparation, pyrrolidinediol derivative stereoselective preparation, hydroxylamine unsaturated cope house cyclization, grignard addition stereoselective dideoxyisopropylidenepentenose benzylnitrone, pentenose dideoxyisopropylidene benzylnitrone stereoselective grignard addition and other aspects.HPLC of Formula: 38838-06-1
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem