Dioxole related

Chen, Mu-Wang published the artcileEnantioselective synthesis of trifluoromethyl substituted piperidines with multiple stereogenic centers via hydrogenation of pyridinium hydrochlorides, Quality Control of 503538-69-0, the publication is Organic Chemistry Frontiers (2015), 2(5), 586-589, database is CAplus.

An enantioselective iridium-catalyzed hydrogenation of trifluoromethyl substituted pyridinium hydrochlorides is described. Introduction of a trifluoromethyl group increases the reactivity due to the electron-withdrawing effect. Three stereogenic centers could be generated in one operation. This methodol. provides a convenient route to chiral poly-substituted piperidines I (R = Me, Et; Ar = Ph, 4-MeC₆H₄, 4-MeOC₆H₄, 2-naphthyl, etc.) and II (Ar = Ph, 4-CF₃C₆H₄, 3,5-F₂C₆H₃, 1-naphthyl) with up to 90% ee.

Organic Chemistry Frontiers published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Quality Control of 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Koz, F. Ferda Yilmaz published the artcileAntioxidant and antimicrobial activities of Codium fragile (Suringar) Hariot (Chlorophyta) essential oil and extracts, HPLC of Formula: 1193-11-9, the publication is Asian Journal of Chemistry (2009), 21(2), 1197-1209, database is CAplus.

Macroalgae are rich sources of natural bioactive products. Their secondary metabolites are attracted attends in many fields of life i.e., food, animal feeding, textile, cosmetics, medicine etc. In this study, methanol, dichloromethane and hexane extracts of Codium fragile (Chlorophyta) were tested for antimicrobial and antioxidant activities. Antioxidant effects were evaluated by hydroxyl radical scavenging assay (deoxyribose degradation assay) and β-carotene bleaching assay. The extracts indicated relatively little antioxidant activities, as compared to com. antioxidants. The composition of the essential oil of C. fragile was also analyzed by GC and GC-MS. Twenty four compounds were identified of C. fragile essential oil and n-tricosane (11.88 %) was determined as major component. Essential oil of C. fragile showed weak antibacterial activity against all gram pos. bacteria tested, except methicillin-oxacillin resistant Staphylococcus aureus ATCC 43300. Similarly, all the extracts of C. fragile showed weak antimicrobial activity on tested organisms.

Asian Journal of Chemistry published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, HPLC of Formula: 1193-11-9.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Yang, Shuijin published the artcileCatalytic synthesis of cyclohexanone ethylene ketal with H₃PW₁₂O₄₀/TiO₂-SiO₂, Application In Synthesis of 177-10-6, the publication is Jingxi Shiyou Huagong Jinzhan (2014), 15(6), 48-50, 54, database is CAplus.

Cyclohexanone and ethylene glycol were used to synthesize cyclohexanone ethylene ketal with H₃PW₁₂O₄₀/TiO₂-SiO₂ as the catalyst which was prepared with method of impregnation. The effects of the molar ratio of cyclohexanone to ethylene glycol, catalyst usage, and reaction time on the yield were studied in experiment The results of experiment have shown that H₃PW₁₂O₄₀/TiO₂-SiO₂ is a good catalyst for the synthesis of cyclohexanone ethylene ketal. The optimum synthesis conditions were identified : n (cyclohexanone) : n (ethylene glycol) = 1 : 1.4, catalyst usage is 0.8% of the total mass of reaction materials, and the usage of cyclohexane, i.e. the water carrying agent, is 6 mL. The yield of cyclohexanone ethylene ketal reaches 77.6% at such conditions.

Jingxi Shiyou Huagong Jinzhan published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H16N2O, Application In Synthesis of 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Du, Xin published the artcileThe construction of a series of hierarchical MWW-type zeolites and their catalytic performances for bulky aldol condensation, Application In Synthesis of 177-10-6, the publication is Microporous and Mesoporous Materials (2018), 117-124, database is CAplus.

The construction of hierarchical pore systems from the post-synthesis modifications of lamellar zeolite catalysts have attracted wide interests to solve the diffusion limitations in the catalytic application of zeolite catalysts. Herein, the interlayer expanded MWW with different interlayer spacing were obtained, based on the post-synthesis modifications of a swollen multilamellar MWW precursor, in which the MWW layers were pillared by cetyltrimethylammonium bromide (CTAB) surfactant with 25 Å interlayer distance. The direct calcination and the post-synthesis modifications led to zeolite catalysts with more open pore structures (hierarchical, interlayer expanded and pillared), which were evidenced by a series of characterizations, such as PXRD, TEM, N₂ adsorption-desorption etc. Moreover, the catalytic performances of the hierarchical MWW (H-MWW), interlayered expanded zeolite IEZ-MWW and Pillared-MWW catalysts were compared with 3D-MWW and ZSM-5 in the condensation of cyclohexanone with glycol or benzaldehyde with 1-pentanol. The catalysts prepared in this study show better catalytic activities than 3D-MWW and ZSM-5.

Microporous and Mesoporous Materials published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Application In Synthesis of 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Gong, Wenpeng published the artcileProgress of research on solid acid catalysts for synthesis of cyclohexanone ethylene ketal, Category: dioxole, the publication is Jingxi Shiyou Huagong Jinzhan (2013), 14(2), 29-33, database is CAplus.

A review. The progress of the research on the application of solid super acid, heteropoly salt, supported heteropoly salt and mol. sieve catalyst in the catalytic synthesis of cyclohexanone ethylene ketal is summarized, and the future development of this application is discussed in this paper.

Jingxi Shiyou Huagong Jinzhan published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Category: dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Cai, Baohua published the artcileKinetic Resolution of 2-Substituted 1, 2-Dihydroquinolines by Rhodium-Catalyzed Asymmetric Hydroarylation, Safety of (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, the publication is Chinese Journal of Chemistry (2021), 39(6), 1606-1610, database is CAplus.

A highly efficient kinetic resolution of racemic 2-substituted 1,2-dihydroquinolines I (R = H, Me, OMe, Cl; R¹ = Me, Ph, Bn, 4-chlorophenyl; R² = Me, Ph, 3,5-dimethylphenyl, etc.) via Rh-catalyzed asym. hydroarylation has been described for the first time. A variety of arylboronic acids ArB(OH)₂ (Ar = Ph, 3-fluorophenyl, naphthalen-2-yl, etc.) coupled with 2-substituted 1,2-dihydroquinolines I under mild reaction condition. The transformations into the enantio-enriched 2,3-diaryl-tetrahydroquinolines II as well as the recovered chiral 2-aryl-dihydroquinolines III were obtained with high yields and excellent enantioselectivities (86%-99% ee, s factor up to 1057).

Chinese Journal of Chemistry published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Safety of (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Liu, Pan published the artcilePhenylalanine Metabolism Is Dysregulated in Human Hippocampus with Alzheimer′s Disease Related Pathological Changes, COA of Formula: C16H10O5, the publication is Journal of Alzheimer’s Disease (2021), 83(2), 609-622, database is CAplus and MEDLINE.

Alzheimer′s disease (AD) is one of the most challenging diseases causing an increasing burden worldwide. Although the neuropathol. diagnosis of AD has been established for many years, the metabolic changes in neuropathol. diagnosed AD samples have not been fully investigated. To elucidate the potential metabolism dysregulation in the postmortem human brain samples assessed by AD related pathol. examination We performed untargeted and targeted metabolomics in 44 postmortem human brain tissues. The metabolic differences in the hippocampus between AD group and control (NC) group were compared. The results show that a pervasive metabolic dysregulation including phenylalanine metabolism, valine, leucine, and isoleucine biosynthesis, biotin metabolism, and purine metabolism are associated with AD pathol. Targeted metabolomics reveal that phenylalanine, phenylpyruvic acid, and N-acetyl-L-phenylalanine are upregulated in AD samples. In addition, the enzyme IL-4I1 catalyzing transformation from phenylalanine to phenylpyruvic acid is also upregulated in AD samples. There is a pervasive metabolic dysregulation in hippocampus with AD-related pathol. changes. Our study suggests that the dysregulation of phenylalanine metabolism in hippocampus may be an important pathogenesis for AD pathol. formation.

Journal of Alzheimer’s Disease published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, COA of Formula: C16H10O5.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Zong, Yang published the artcileHighly efficient acetalization and ketalization catalyzed by cobaloxime under solvent-free condition, Quality Control of 177-10-6, the publication is Catalysts (2018), 8(2), 48/1-48/10, database is CAplus.

An efficient catalytic system was developed for the acetalization and ketalization of carbonyl compounds with polyhydric alcs. under mild solvent-free conditions. In the presence of 0.1 mol% CoCl₂ and 0.2 mol% dimethylglyoxime at 70° under 5 KPa pressure for 1 h, 95.3% conversion of cyclohexanone and 100% selectivity of the corresponding cyclic ketal could be obtained, where TOF reached as high as 953 h^-1. It is proposed that the in situ generated planar tetracoordinate cobaloxime played the key role in the catalytic cycle and was responsible for the excellent catalytic performance.

Catalysts published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C37H30ClIrOP2, Quality Control of 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Zeng, Chaoyuan published the artcileIridium/copper-cocatalyzed asymmetric ring opening reaction of azabenzonorbornadienes with amines, Name: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, the publication is Organic & Biomolecular Chemistry (2015), 13(31), 8425-8428, database is CAplus and MEDLINE.

A combination of iridium/copper associated with (R)-Difluorphos catalyst for the asym. ring opening reaction of azabenzonorbornadienes with amines was developed, which afforded chiral trans-vicinal diamines in 80-97% yields with 93-95% enantioselectivities.

Organic & Biomolecular Chemistry published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C22H23BO4, Name: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Lv, Shenghua published the artcileStructure and properties of copolymer tannage of vanillin and gallic acid with HRP initiation, Quality Control of 68527-74-2, the publication is Advanced Materials Research (Durnten-Zurich, Switzerland) (2012), 282-286, database is CAplus.

A copolymer of vanillin and gallic acid was synthesized using HRP/H₂O₂ as initiator. The chem. structure of the copolymer was characterized by means of FTIR, NMR and GPC. The copolymer was applied in making leather as a tanning agent and the shrinkage temperature (Ts) of tanned leather reached 82.5°C. The average thickness increment ratio (E) of re-tanned leather was 19.4%. It has also excellent assisting dyeing and soft leather fibers properties. The application leather has desired dyeing effect and excellent softness.

Advanced Materials Research (Durnten-Zurich, Switzerland) published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C11H14O4, Quality Control of 68527-74-2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem