Dioxole related

Yu, Shuangjian published the artcileEffects of dynamic covalent bond multiplicity on the performance of vitrimeric elastomers, HPLC of Formula: 68527-74-2, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2020), 8(39), 20503-20512, database is CAplus.

It is still a challenge to integrate multiple dynamic covalent bonds (DCBs) into one network, so the effects of DCB multiplicity on the performance of covalent adaptable networks (CANs) are still unclear. In this contribution, based on the versatility of vanillin chem., we realized the construction of CANs containing different DCB multiplicities, and thus the influences of DCB multiplicity on the vitrimeric performance of the networks are fairly investigated. It turns out that, with increasing DCB multiplicity, the relaxation time of the networks can be reduced significantly because the dynamic performance of the CANs with double or triple DCBs is determined by not only the activation energy but the synergistic effect of different DCBs. A plausible method was first proposed to quantify the synergistic effect of DCB multiplicity. We envisage that the disclosed findings will provide significant insight into the optimized design of CANs with tunable dynamic performance.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 68527-74-2. 68527-74-2 belongs to dioxole, auxiliary class Dioxolane,Benzene,Phenol,Ether, name is 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol, and the molecular formula is C7H7BrN2O2, HPLC of Formula: 68527-74-2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

An, Shunyong published the artcileSynthesis optimization and kinetics for ketalization of cyclohexanone with ethylene glycol in a zeolite membrane reactor, HPLC of Formula: 177-10-6, the publication is Shiyou Xuebao, Shiyou Jiagong (2014), 30(3), 527-535, database is CAplus.

Ketalization of cyclohexanone with ethylene glycol was investigated in a pervaporation (PV) membrane reactor by using high-flux zeolite T membrane and zeolite H-β catalyst. A kinetic model was built for the PV-aided ketalization based on the assumption of second-order reaction, and the exptl. data were compared with the model predictions. The molar ratio of cyclohexanone to ethylene glycol and catalyst amount for the reaction occurring in membrane reactor were optimized, meanwhile, the reusability of zeolite T membrane and the solid catalyst in the ketalization were investigated. The conversion of cyclohexanone increased from 64.3% to almost completion due to water removal from the reaction system by the aid of PV process. The reaction could be carried out under the close theor. ratios of reagents, so that the reaction atom economy was enhanced. Zeolite T membrane was stable in reaction mixture and showed a good reusability for the reaction.

Shiyou Xuebao, Shiyou Jiagong published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, HPLC of Formula: 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Kandasamy, Sabariswaran published the artcileHydrothermal liquefaction of microalgae using Fe₃O₄ nanostructures as efficient catalyst for the production of bio-oil: Optimization of reaction parameters by response surface methodology, Related Products of dioxole, the publication is Biomass and Bioenergy (2019), 105417, database is CAplus.

The aim of the present work was focused on optimizing the hydrothermal liquefaction (HTL) of Spirulina platensis catalyzed by Fe₃O₄ nanostructures to enhance the bio-oil yield and quality of bio-oil using response surface methodol. (RSM). The structural morphol. and crystalline nature of the synthesized catalyst was determined using a scanning electron microscope (SEM), high resolution transmission electron microscopy (HR-TEM) and X-ray powder diffraction (XRD). Three of the vital reaction parameters such as temperature, holding time and catalyst dosage were optimized through central composite design. A maximum bio-oil yield of 32.33% was observed for the high temperature at 320°C, 0.75 g of catalyst dosage and 37 min of resident time. The maximum conversion was found at a lower temperature of 272°C, the bio-oil yield of 27.66% was obtained with 0.45 g of catalyst dosage and 24 min of holding time which is an energy efficient optimum condition. The maximum bio-oil yield was influenced at a lower temperature due to the high catalytic activity. While compared to higher temperatures were not much influence was observed It clearly states that the catalyst dosage playing a critical role in the lower temperature HTL reaction. GC-MS and FT-IR anal. of the produced bio-oil exhibits significant characteristics for biofuel applications. The Fe₃O₄ catalyst was recyclable for up to eight repeated cycles and constant bio-oil yield for the last four cycles. It shows the excellent reproduction ability towards HTL of Spirulina sp.

Biomass and Bioenergy published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Related Products of dioxole.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Salem, Mohamed Z. M. published the artcileGC/MS Analysis of Oil Extractives from Wood and Bark of Pinus sylvestris, Abies alba, Picea abies, and Larix decidua, Product Details of C8H14O2, the publication is BioResources (2015), 10(4), 7725-7737, database is CAplus.

Wood and bark oil extractives components (OECs) of Pinus sylvestris, Abies alba, Picea abies and Larix decidua grown in the Czech Republic were analyzed using gas chromatog./ mass spectrometry (GC/MS). The anal. showed the presence of monoterpene, sesquiterpene, diterpenoids, and resin acids. The highest percentages of OECs in the wood of P. sylvestris were α-fenchyl alc. (26.04%), D-fenchyl alc. (12.39%), and L-borneol (8.81%); the OECs in the bark included α-methyl-γ-butyrolactone (31.88%) and isodecyl octyl phthalate (15.85%). The most frequently occurring OEC in A. alba wood were 4-hydroxy-4-methyl-2-pentanone (73.36%), α-cedrol (10.08%), and 2,6-dimethyl-1,3,6-heptatriene (7.35%); the most OECs in the bark were di(2-ethylhexyl)phthalate (59.83%), Me cyclopentane (16.63%), and 13-epimanool (6.31%). P. abies wood OECs included 4-hydroxy-4-methyl-2-pentanone (29.42%), α-cedrol (26.98%), Δ-3-carene (6.08%), and terpinen-4-ol (5.42%); the most OECs in the bark were di(2-ethylhexyl)phthalate (30.91%), cyclohexane (12.89%), caryophyllene oxide (8.90%), and α-pinene (4.59%). OECs of L. decidua wood were α-terpineol (26.06%), isoborneol (14.12%), camphene (11.78%), D-fenchyl alc. (10.39%), and larixol (4.85%); OECs in the bark were larixol (33.29%), phthalic acid mono-2-ethylhexyl ester (16.96%), 13-epimanool (15.40%), and cyclohexane (8.44%).

BioResources published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Product Details of C8H14O2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Sang, Hui Leng published the artcileCobalt-catalyzed regioselective stereoconvergent Markovnikov 1,2-hydrosilylation of conjugated dienes, Application In Synthesis of 503538-69-0, the publication is Chemical Science (2018), 9(4), 973-978, database is CAplus and MEDLINE.

The authors report the 1st stereoconvergent Markovnikov 1,2-hydrosilylation of conjugated dienes using catalysts generated from bench-stable Co(acac)₂ and phosphine ligands. A wide range of E/Z-dienes underwent this Markovnikov 1,2-hydrosilylation in a stereoconvergent manner, affording (E)-allylsilanes in high isolated yields with high stereoselectivities (E/Z = >99 : 1) and high regioselectivities (b/l up to > 99 : 1). Mechanistic studies revealed that this stereoconvergence stems from a σ-π-σ isomerization of an allylcobalt species generated by the 1,4-hydrometalation of Z-dienes. A Co catalyst that can only catalyze the hydrosilylation of the E-isomer of an (E/Z)-diene was identified, which allows the separation of the (Z)-isomer from an isomeric mixture of (E/Z)-dienes. Also, asym. hydrosilylation of (E)-1-aryl-1,3-dienes was studied with Co(acac)₂/(R)-difluorphos and good enantioselectivities (er up to 90:10) were obtained.

Chemical Science published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, Application In Synthesis of 503538-69-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Yang, Shuijin published the artcileSynthesis of acetals and ketals catalyzed by H₄SiW₆Mo₆O₄₀/SiO₂, Computed Properties of 177-10-6, the publication is Advanced Materials Research (Durnten-Zurich, Switzerland) (2012), 430-432(Pt. 1), 289-292, database is CAplus.

Heterogeneous acid catalyst, H₄SiW₆Mo₆O₄₀/SiO₂ was synthesized by a sol-gel technique. Catalytic application of the catalyst for synthesis of acetals and ketals were tested. The variation of different reaction parameters on the yield of acetals and ketals were also studied. The yields of acetals and ketals can reach 80.0%∼96.9% at the optimized conditions. The high activity and stability of the catalyst is well retained after 4 runs. The results reveal that the H₄SiW₆Mo₆O₄₀/SiO₂ catalysis is a novel, effective and reusable catalyst for synthesizing acetals and ketals.

Advanced Materials Research (Durnten-Zurich, Switzerland) published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C14H26O2, Computed Properties of 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Huang, Yong Kui published the artcileCatalytic application of H₃PW₆Mo₆O₄₀/SiO₂ in synthesis of acetals and ketals, Product Details of C8H14O2, the publication is Advanced Materials Research (Durnten-Zurich, Switzerland) (2012), 304-307, database is CAplus.

Novel catalyst H₃PW₆Mo₆O₄₀/SiO₂ was prepared by a sol-gel technique and its catalytic application in synthesis of acetals and ketals was tested. Conditions for preparation of the catalyst were optimized by using the orthogonal exptl. design. The optimum conditions are: the mass ratio of H₃PW₆Mo₆O₄₀ to SiO₂ is 0.4, calcination temperature is 150 °C and calcination time is 3 h. The steric properties of the reactants play an important role in the acetalization. The catalytic activity of the catalyst decreases when the size of the reactant increased. Although a decrease in catalytic activity was observed with its subsequent reuse, the catalyst could be reused at least four times without any other treatments. The results reveal that the H₃PW₆Mo₆O₄₀/SiO₂ catalysis generally results in good yields of acetals and ketals under mild reaction conditions.

Advanced Materials Research (Durnten-Zurich, Switzerland) published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Product Details of C8H14O2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Deng, Lan published the artcileA novel synthesis method of baicalein derivatives and their bronchodilation activity, SDS of cas: 110204-45-0, the publication is Zhongguo Yaoke Daxue Xuebao (2010), 41(5), 414-418, database is CAplus.

Ten baicalein derivatives with bronchodilation activity were selectively synthesized using baicalin as a starting material and applying its glucosyl group as a protecting group. Their structures were confirmed by IR, MS, and ¹H NMR data. The preliminary biol. assay results showed that the baicalein derivatives could inhibit contraction of tracheal smooth muscle induced by acetylcholine (Ach), KCl, and histamine (His) in guinea pig. This finding indicates a potential application of baicalein derivatives in chronic obstructive pulmonary diseases (COPD).

Zhongguo Yaoke Daxue Xuebao published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, SDS of cas: 110204-45-0.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Demirel, Zeliha published the artcileAntimicrobial and antioxidant activity of brown algae from the Aegean Sea, Recommanded Product: 2,2,4-Trimethyl-1,3-dioxolane, the publication is Journal of the Serbian Chemical Society (2009), 74(6), 619-628, database is CAplus.

The present study was conducted to evaluate the antioxidant and anti-microbial activity of methanol, dichloromethane and hexane extracts, as well as the essential oils of brown algae (Phaeophyta) Colpomenia sinuosa, Dictyota dichotoma, Dictyota dichotoma var. implexa, Petalonia fascia and Scytosiphon lomentaria. The essential oil of the macroalgae was obtained by steam distillation and analyzed by GC and GC/MS. The antioxidant activity of the algal extracts was determined using the procedures of inhibition of β-carotene bleaching and ABTS⁺ methods. The antioxidant effects of the extracts were compared with those of com. antioxidants, such as butylated hydroxytoluene (BHT), butylated hydroxyanisol (BHA) and α-tocopherol. The hexane extracts of D. dichofoma var. implexa had a higher phenolic content than the other extracts The dichloromethane extract of S. lomentaria was found to be more active in the decolorization of ABTS⁺ than the other extracts and generally the dichloromethane extracts were more active than the methanol and hexane extracts Antimicrobial activities of the extracts were assessed against Gram (+) and Gram (-) bacteria and one yeast strain by the disk diffusion method. According to the results, the dichloromethane extracts generally showed more potent antimicrobial activity than the methanol and hexane extracts at concentrations 1.5 and 1.0 mg/disk.

Journal of the Serbian Chemical Society published new progress about 1193-11-9. 1193-11-9 belongs to dioxole, auxiliary class Dioxolanes, name is 2,2,4-Trimethyl-1,3-dioxolane, and the molecular formula is C6H12O2, Recommanded Product: 2,2,4-Trimethyl-1,3-dioxolane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Lee, Yashang published the artcileIncreased Anti-P-glycoprotein Activity of Baicalein by Alkylation on the A Ring, Recommanded Product: 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, the publication is Journal of Medicinal Chemistry (2004), 47(22), 5555-5566, database is CAplus and MEDLINE.

The aqueous extract of Scutellariae baicalensis Georgi has inhibitory activity against P-gp 170, a multiple drug resistant gene product. Baicalein, one of the major flavones, was found to be responsible for this activity. The hydroxyl groups of the A ring of baicalein were systematically alkylated in order to assess the effect of such modifications on the activity against P-gp 170. The impact of the baicalein modifications on activity against the growth of a human nasopharyngeal cancer cell line KB and its P-gp 170 overexpressing cell line KB/MDR were also examined The results indicate that alkylation of R5 of baicalein does not have a major impact on the interaction with P-gp 170, whereas alkylation of R6 or R7 alone or both, could enhance the interaction of baicalein with P-gp 170 as well as the amount of intracellular accumulation of vinblastine, a surrogate marker for the activity of P-gp 170 pump of KB/MDR cells. In this case, the optimal linear alkyl functionality is a Pr side chain. These modifications could also alter the activity of compounds inhibiting cell growth. Among the different compounds synthesized, the most potent mol. against P-gp 170 is 5-methoxy-6,7-dipropyloxyflavone. Its inhibitory activity against P-gp 170 is approx. 40 times better, based on EC₅₀ (concentration of the compound enhancing 50% of the intracellular vinblastine accumulation in the KB/MDR cells) and 3 times higher, based on A_max (the intracellular vinblastine accumulation of the KB/MDR cells caused by the compound) as compared to baicalein. One compound is also a more selective inhibitor than baicalein against P-gp 170, because its cytotoxicity is less than that observed for baicalein. The growth inhibitory IC₅₀ of the compound against KB and KB/MDR cells are about the same, suggesting that compound 23 is unlikely to be a substrate of P-gp 170 pump. Acetylation of R6, R7 or both could also decrease EC₅₀ and increase A_max. Acetylated compounds are more toxic than baicalein, and their potency against cell growth is compromised by the presence of P-gp 170, suggesting that these compounds are substrates of P-gp 170. Benzylation of R6 or R7 but not both also enhanced anti-P-gp170 activity and potency against cell growth; however, the presence of P-gp 170 in cells did not have an impact on their sensitivity to these mols., suggesting that the benzylated compounds are inhibitors but not substrates of P-gp 170, and perhaps have a different mechanism of action. In conclusion, the substitutions of R6 and R7 hydroxyl groups by alkoxy groups, acetoxy groups, or benzyloxy groups could yield compounds with different modes of action against P-gp 170 with different mechanisms of action against cell growth.

Journal of Medicinal Chemistry published new progress about 110204-45-0. 110204-45-0 belongs to dioxole, auxiliary class Flavonoids, name is 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one, and the molecular formula is C16H10O5, Recommanded Product: 9-Hydroxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem