Dioxole related

Synthesis 2-bromomethyl-2-aryl-1,3-dioxolanes – the precursors of adrenoceptor blockers was written by Vershinin, S. S.;Kotlov, V. M.;Klimakov, V. S.;Mindiyarova, E. R.;Zorin, V. V.. And the article was included in Bashkirskii Khimicheskii Zhurnal in 2011.Reference of 3418-21-1 This article mentions the following:

The effective method for preparation of 2-bromomethyl-2-R-1,3-dioxolanes I [R = Ph, 4-ClC₆H₄], the precursors of adrenoceptor blockers α and β, is developed. Intermediate 2-methyl-2-R-1,3-dioxolanes were obtained in high yields (up to 95%) via microwave-assisted heterocyclization of RC(O)Me with HOCH₂CH₂OH, which proceeds 12 times faster than heat-assisted reactions. Bromination of the resultant intermediates with mol. bromine selectively gave I [R = Ph, 4-ClC₆H₄] in 98 and 96% yields, resp. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Reference of 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Reference of 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Polyphenylene as an electron transfer catalyst in lithiation processes was written by Yus, Miguel;Gomez, Cecilia;Candela, Pablo. And the article was included in Tetrahedron in 2002.Formula: C7H13ClO2 This article mentions the following:

The lithiation of different functionalized chlorinated materials, dichlorinated compounds and benzofused cyclic ethers with lithium powder in the presence of catalytic amounts of either linear (LPP) or crosslinked (CPP) polyphenylene, in THF at temperatures ranging between -78 and 20°C, leads to the expected organolithium intermediates, which by reaction with electrophiles [Bu^tCHO, PhCHO, Et₂CO, (CH₂)₅CO, PhCOMe, Me₃SiCl] gives, after hydrolysis with water, the expected products. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Formula: C7H13ClO2).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C7H13ClO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

One-pot synthesis of α-bromoacetals of ketones from secondary alcohols and 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) in ethylene glycol was written by Han, Bingbing;Zheng, Zubiao;Wu, Fang;Wang, Aidong. And the article was included in Synthetic Communications in 2017.Related Products of 3418-21-1 This article mentions the following:

α-Bromoacetals of ketones were prepared from various secondary alcs. with 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) and ethylene glycol through oxidation, bromination, and acetalization in one pot without the use of other catalysts under mild conditions. The effects of DBDMH, the solvent, and N-bromosuccinimide on the reaction were investigated. Under the optimal conditions, most α-bromoacetals of ketones were obtain in 90-98% yields. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Related Products of 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Related Products of 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

m-Terphenyl ethers, a new hydroxy protecting group cleavable under reductive single electron transfer reaction conditions was written by Azzena, Ugo;Mocci, Sarah;Pisano, Luisa. And the article was included in Synthesis in 2011.Synthetic Route of C7H13ClO2 This article mentions the following:

2,6-Diphenylphenyl ethers and, to a lesser extent, 2,6-dimethoxyphenyl ethers, were tested as protected hydroxyl derivatives under a variety of reaction conditions. These ethers underwent regioselective cleavage of the aromatic C(1)-O bond under reductive SET reaction conditions using alkali metals in THF at room temperature This deprotective procedure was efficiently realized in the presence of several other functional groups, including an acetal, a Ph alkyl ether, an unprotected alc., and C-C double and triple bonds. Furthermore, meta-terphenyl ethers proved stable under different reaction conditions, including acidic hydrolysis and formation and/or employment of different organometallic reagents. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Synthetic Route of C7H13ClO2).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Synthetic Route of C7H13ClO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Novel Dioxolane Ring Compounds for the Management of Phytopathogen Diseases as Ergosterol Biosynthesis Inhibitors: Synthesis, Biological Activities, and Molecular Docking was written by Min, Li-Jing;Wang, Han;Bajsa-Hirschel, Joanna;Yu, Chen-Sheng;Wang, Bin;Yao, Meng-Meng;Han, Liang;Cantrell, Charles L.;Duke, Stephen O.;Sun, Na-Bo;Liu, Xing-Hai. And the article was included in Journal of Agricultural and Food Chemistry in 2022.SDS of cas: 3418-21-1 This article mentions the following:

Thirty novel dioxolane ring compounds were designed and synthesized. Their chem. structures were confirmed by ¹H NMR, HRMS and single crystal X-ray diffraction anal. Bioassays indicated that these dioxolane ring derivatives exhibited excellent fungicidal activity against Rhizoctonia solani, Pyricularia oryzae, Botrytis cinerea, Colletotrichum gloeosporioides, Fusarium oxysporum, Physalospora piricola, Cercospora arachidicola, and herbicidal activity against lettuce (Lactuca sativa), bentgrass (Agrostis stolonifera) and duckweed (Lemna pausicostata). Among these compounds, 1-((2-(4-chlorophenyl)-5-methyl-1,3-dioxan-2-yl)methyl)-1H-1,2,4-triazole (D17), 1-(((4R)-2-(4-chlorophenyl)-4-methyl-1,3-dioxolan-2-yl)methyl)-1H-1,2,4-triazole (D20), 1-((5-methyl-2-(4-(trifluoromethyl)phenyl)-1,3-dioxan-2-yl)methyl)-1H-1,2,4-triazole (D22) and 1-((2-(4-fluorophenyl)-1,3-dioxolan-2-yl)methyl)-1H-1,2,4-triazole (D26) had broad spectrum fungicidal and herbicidal activity. The IC₅₀ values against duckweed were 20.5 ± 9.0, 14.2 ± 6.7, 24.0 ± 11.0, 8.7 ± 3.5 and 8.0 ± 3.1μM for D17, D20, D22, D26 and pos. control difenoconazole, resp. The EC₅₀ values were 7.31 ± 0.67, 9.74 ± 0.83, 17.32 ± 1.23, 11.96 ± 0.98 and 8.93 ± 0.91 mg/L for D17, D20, D22, D26 and the pos. control difenoconazole against the plant pathogen R. solani, resp. Germination experiments with Arabidopsis seeds indicated that the target of these dioxolane ring compounds in plants is brassinosteroid biosynthesis. Mol. simulation docking results of compound D26 and difenoconazole with fungal CYP51 P 450 confirmed that they both inhibit this enzyme involved in ergosterol synthesis. The structure-activity relationships (SAR) are discussed by substituent effect, mol. docking and d. functional theory anal., which provided useful information for designing more active compounds In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1SDS of cas: 3418-21-1).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.SDS of cas: 3418-21-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Lithiation reactions catalyzed by linear and cross-linked arene-based polymers. Generation of functionalized organolithium compounds was written by Candela, P.;Gomez, C.;Yus, M.. And the article was included in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) in 2004.Computed Properties of C7H13ClO2 This article mentions the following:

Lithiation of various substrates, such as chlorinated acetals (e.g. 2-(4-chlorobutyl)-1,3-dioxolane), α-chloro ether, dichloro derivatives, benzo-fused heterocycles (e.g. isobenzofuran), and allyl and benzyl derivatives, with excess Li powder in the presence of a catalytic amount of soluble linear or insoluble cross-linked arene (naphthalene or biphenyl)-based polyolefins, yields the expected organolithium intermediates. The latter react with electrophiles (e.g. Et₂CO) either in two steps or under Barbier-type reaction conditions to afford the corresponding adducts. The catalyst is easily recuperated by filtration at the end of the process, and the procedure can be regarded as a reasonable alternative to the use of free arenes as electron carrier in lithiation reactions. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Computed Properties of C7H13ClO2).

2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Computed Properties of C7H13ClO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Purines. L. Synthesis and antileukemic activity of the antibiotic guanine 7-oxide and its 9-substituted derivatives was written by Ogawa, Kazuo;Nishii, Masahiro;Inagaki, Jinichiro;Nohara, Fujio;Saito, Tohru;Itaya, Taisuke;Fujii, Tozo. And the article was included in Chemical & Pharmaceutical Bulletin in 1992.Computed Properties of C10H11BrO2 This article mentions the following:

Condensation of phenacyl bromide with amines gave PhCOCH₂NHCH₂R [R = 4-MeOC₆H₄, 3,4-(MeO)₂C₆H₃, 3,4-methylenedioxyphenyl] which were condensed with a chloropyrimidinone to give adducts I. Cyclization of I gave substituted guanine oxides II which were debenzylated to give the title compound (III). A series of alkyl and cycloalkyl substituted guanine oxides were prepared by the same methodol. All the substituted guanine oxides were tested for antileukemic activity and none were superior to III. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Computed Properties of C10H11BrO2).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Computed Properties of C10H11BrO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

One-step for the preparation of α-haloacetal of ketones with N-bromosuccinimide/N-chlorosuccinimide (NBS/NCS) and ethylene glycol was written by Zheng, Zubiao;Han, Bingbing;Wu, Fang;Shi, Tengfei;Liu, Jie;Zhang, Yong;Hao, Jialong. And the article was included in Tetrahedron in 2016.Formula: C10H11BrO2 This article mentions the following:

A new process that could directly prepare α-haloacetal of ketones from various ketones with N-halosuccinimide (NBS/NCS) and ethylene glycol in one step without any other catalysts is reported. The effects of solvents, NBS/NCS and reaction temperature were studied. Under the optimal condition, most of α-haloacetals of ketones were obtained in 90-100% yield. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Formula: C10H11BrO2).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C10H11BrO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

A convenient procedure for the synthesis of acetals from α-halo ketones was written by Carlson, Rolf;Gautun, Hanna;Westerlund, Andreas. And the article was included in Advanced Synthesis & Catalysis in 2002.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

A study for determining the scope and limitations of a procedure for synthesizing ethylene acetals from haloketones is presented. The method uses 1,2-bis(trimethylsilyloxy)ethane, BTSE, as reagent and Nafion-TMS as catalyst. Two procedures have been tested: (A) stoichiometric amounts of the haloketone and BTSE and a catalytic amount of Nafion-TMS were heated to reflux in chloroform solution, and (B) stoichiometric amounts of the reactants and a catalytic amount of Nafion-TMS were heated to 90-100°C in the absence of solvent. The following ketones have been tested: 2-bromo-1-phenyl-1-ethanone, 2-bromo-cyclopentenone, 3-bromo-3-methyl-2-butanone, 3-chloro-3-methyl-2-butanone, 1-bromo-3,3-dimethyl-2-butanone, 1-chloro-3,3-dimethyl-2-butanone, 2-bromocyclohexanone, 2-chloro-1-cyclohexyl-1-ethanone, 1,1-dibromo-3,3-dimethyl-2-butanone, 1,3-dibromo-3-methyl-2-butanone, 1,3-dibromo-2-butanone, 1,3-dibromo-2-propanone, 2-chloro-1-phenyl-1-ethanone, and endo-2-bromocamphor. Yields were in the range 57-100% with the exceptions of endo-2-bromocamphor which afforded <10% yield and the dibromoketones 1,1-dibromo-3,3-dimethyl-2-butanone and 1,3-dibromo-3-methyl-2-butanone for which the method failed. Factors determining the scope and limitations are briefly discussed. Full exptl. details and spectroscopic data of the acetals are given. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Quality Control of 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

One-pot synthesis of some new α-bromoketals and acetals via 1,8-diazabicyclo[5.4.0] undec-7-ene-hydrobromide-perbromide was written by Hajizadeh, Neda;Bakavoli, Mehdi;Pordel, Mehdi. And the article was included in Iranian Journal of Chemistry & Chemical Engineering in 2017.Recommanded Product: 2-(Bromomethyl)-2-phenyl-1,3-dioxolane This article mentions the following:

α-Bromoketals and acetals are important synthetic precursors in organic synthesis. In this work, some new α-bromoketals are synthesized by the reaction of aryl Me ketones with diols in the presence of 1,8-diazabicyclo[5.4.0] undec-7-ene (DBU) hydrobromide-perbromide in good isolated yields. The latter compound converts aldehydes to acetals and serves as a new and efficient reagent for the synthesis of acetals. Comparative studies of the preparation of α-bromoketal and acetals using some reported methods vs. the present method show that DBUH-Br₃ is one of the most efficient reagents for the preparation of these compounds Conversion of carbonyl compounds to corresponding α-bromoketals and acetals in the presence of DBUH-Br₃ under microwave irradiation is also described. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1Recommanded Product: 2-(Bromomethyl)-2-phenyl-1,3-dioxolane).

2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Recommanded Product: 2-(Bromomethyl)-2-phenyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem