Dioxole related

Preparation of SO₄^2-/TiO₂-MoO₃ solid superacid and its catalytic activity in acetalation and ketalation was written by Yang, Shuijin;Liang, Yongguang;Yu, Xieqing;Sun, Jutang. And the article was included in Chinese Journal of Chemical Engineering in 2005.Recommanded Product: 126-39-6 This article mentions the following:

The SO₄^2-/TiO₂-MoO₃ solid superacid was prepared and its catalytic activity under different synthetic conditions was examined with esterification of n-butanoic acid and Bu alc. as probing reaction. Optimum conditions for catalyst preparation were determined, i.e., the mass ratio of MoO₃ is 25%, the calcination temperature 450°, and the soaked consistency of H₂SO₄ is 0.5 mol·L^-1. The superacid catalyst was evaluated in the preparation of six ketals and acetals. Under molar ratio of aldehyde/ketone to glycol 1:1.5, mass ratio of catalyst to reactants of 0.5%, and reaction time of 1.0 h, the yield of ketals and acetals was up to 63.2%. The catalyst can be easily recovered and reused. In the experiment, the researchers used many compounds, for example, 2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6Recommanded Product: 126-39-6).

2-Ethyl-2-methyl-1,3-dioxolane (cas: 126-39-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: 126-39-6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Studies on tridecaptin B₁, a lipopeptide with activity against multidrug resistant Gram-negative bacteria was written by Cochrane, Stephen A.;Lohans, Christopher T.;van Belkum, Marco J.;Bels, Manon A.;Vederas, John C.. And the article was included in Organic & Biomolecular Chemistry in 2015.Category: dioxole This article mentions the following:

Previously, other groups had reported that Paenibacillus polymyxa NRRL B-30507 produces SRCAM 37, a type IIA bacteriocin with antimicrobial activity against Campylobacter jejuni. Genome sequencing and isolation of antimicrobial compounds from this P. polymyxa strain show that the antimicrobial activity is due to polymyxins and tridecaptin B₁. The complete structural assignment, synthesis, and antimicrobial profile of tridecaptin B₁ is reported, as well as the putative gene cluster responsible for its biosynthesis. This peptide displays strong activity against multidrug resistant Gram-neg. bacteria, a finding that is timely to the current problem of antibiotic resistance. In the experiment, the researchers used many compounds, for example, 2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9Category: dioxole).

2-(3-Bromopropyl)-1,3-dioxolane (cas: 62563-07-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and cardiotonic activity of a series of substituted 4-alkyl-2(1H)-quinazolinones was written by Bandurco, Victor T.;Schwender, Charles F.;Bell, Stanley C.;Combs, Donald W.;Kanojia, Ramesh M.;Levine, Seymour D.;Mulvey, Dennis M.;Appollina, Mary A.;Reed, Marianne S.. And the article was included in Journal of Medicinal Chemistry in 1987.Reference of 28657-75-2 This article mentions the following:

The synthesis, cardiac fraction III cyclic nucleotide phosphodiesterase (PDE-III) inhibition, and pos. inotropic activity of a series of 2(1H)-quinazolinones are reported. A general synthesis of the series involves the cyclization of 2-aminoacetophenones with KOCN in AcOH. Modifications at the 4-position of the quinazoline nucleus are best achieved by forming the intermediate N₁-acyl-N₃-phenylurea from the appropriate substituted PhNCO and amide. Polyphosphoric acid effects cyclizaiton to the quinazoline product. Generally the structure-activity relationships for the series parallel the 5-point model previously published for PDE-III inhibition. The most active analog of the series is 5,6-dimethoxy-4-methyl-2(1H)-quinazolinone (I) (ORF 16,600), which has ca. twice the i.v. potency of amrinone and is being developed as an oral cardiotonic. In the experiment, the researchers used many compounds, for example, 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2Reference of 28657-75-2).

1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Reference of 28657-75-2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of vanillin 1,2-propylene glycol acetal catalyzed by iodine was written by Wang, Yong-lan;Bo, Hui-ying;Wang, Hong-she. And the article was included in Huaxue Gongchengshi in 2013.COA of Formula: C11H14O4 This article mentions the following:

Vanillin 1,2-propylene glycol acetal was synthesized through the condensation of vanillin with 1,2-propylene glycol using iodine as a catalyst. The effects of the molar ratio of reactant, the amount of catalyst, reaction temperature and reaction time on the yield of product were discussed. The results showed that the optimized reaction conditions are as follows: the molar ratio of vanillin (0.1 mol) to 1,2-propylene glycol (0.18 mol) is 1 : 1.8; the amount of catalyst is 1.2 g, reaction temperature is 60°C and the reaction time is 20 min. Under the optimum conditions mentioned above, the yield of vanillin 1,2-propylene glycol acetal reached more than 91.3%. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2COA of Formula: C11H14O4).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.COA of Formula: C11H14O4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

A practical RuCl₃-catalyzed oxidation using trichloroisocyanuric acid as a stoichiometric oxidant under mild nonacidic conditions was written by Yamaoka, Hidenori;Moriya, Narimasa;Ikunaka, Masaya. And the article was included in Organic Process Research & Development in 2004.Electric Literature of C12H20O6 This article mentions the following:

The combined use of catalytic RuCl₃ and stoichiometric trichloroisocyanuric acid in the presence of n-Bu₄NBr and K₂CO₃ allowed smooth oxidation of primary alcs. to carboxylic acids. Secondary alcs. can be oxidized to ketones when using the same set of the reagents. By proceeding under the nonacidic biphasic conditions dispensing with hazardous reagents, the oxidation reactions were applicable to structurally diverse alcs., easy to work up, environmentally benign, and basically high-yielding. In the experiment, the researchers used many compounds, for example, (3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1Electric Literature of C12H20O6).

(3aS,4S,6R,6aS)-6-((R)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol (cas: 14131-84-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Electric Literature of C12H20O6

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Seasonal variation of the composition of essential oils from Piper cernuum Vell and Piper rivinoides Kunth, ADMET study, DFT calculations, molecular docking and dynamics studies of major components as potent inhibitors of the heterodimer methyltransferase complex NSP16-NSP10 SARS COV-2 protein was written by Alves Borges Leal, Antonio Linkoln;Fonseca Bezerra, Camila;Ferreira e Silva, Andressa Kelly;Everson da Silva, Luiz;Bezerra, Lucas Lima;Almeida-Neto, Francisco Wagner;Marinho, Emanuelle Machado;Celedonio Fernandes, Carla Freire;Nunes da Rocha, Matheus;Marinho, Marcia Machado;Coutinho, Henrique D. M.;Barreto, Humberto Medeiros;Rafaela Freitas Dotto, Ana;Amaral, Wanderlei do;Santos, Helcio Silva dos;Lima-Neto, Pedro de;Marinho, Emmanuel Silva. And the article was included in Journal of Biomolecular Structure and Dynamics.Formula: C11H12O3 This article mentions the following:

Coronavirus disease (COVID-19) has the virus that causes the SARS-CoV-2 severe acute respiratory syndrome, which has reached a pandemic proportion, with thousands of deaths worldwide already registered. In this context, the present study aimed to evaluate the influence of seasonality on the yield and chem. composition of the essential oils of Piper cernuum and Piper rivinoides as well as to evaluate the anti-SARS-CoV-2 potential of the major components of each oil by mol. docking and quantum chem. calculation (D. Functional Theory method), being possible indicate that the winter and autumn periods, the seasons of the year where it is possible to obtain the highest percentage of Piper cernuum and Piper rivinoides oils, resp. Regarding the anti-SARS-Cov-2 potential, the present work showed that the dihydroagarofuran present in Piper cernuum, presented a strong interaction with amino acid residues from Mpro, presenting a potential similar to Remdesivir, a drug for clin. use. Regarding methyltransferase, dihydroagarofuran (Piper cernuum) and myristicin (Piper rivinoids) showed better affinity, with important interactions at the active site of the inhibitor Sinefugin, suggesting a potential inhibitory effect of the heterodimer methyltransferase complex NSP16-NSP10 SARS Cov-2. Mol. docking and mol. dynamics studies represent an initial step, being indicative for future in vitro studies of dihydroagarofuran and myristicin, as possible pharmacol. tools for COVID-19. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0Formula: C11H12O3).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Formula: C11H12O3

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

1,2,4-Benzothiadiazine derivatives as α₁ and 5-HT_1A receptor ligands was written by Tait, Annalisa;Luppi, Amedeo;Franchini, Silvia;Preziosi, Elisa;Parenti, Carlo;Buccioni, Michela;Marucci, Gabriella;Leonardi, Amedeo;Poggesi, Elena;Brasili, Livio. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Reference of 4360-63-8 This article mentions the following:

A series of 1,2,4-benzothiadiazine derivatives I (R = H, Me, Cl) and II with an arylpiperazine moiety linked at position 3 of the heterocyclic ring were synthesized and assessed for their pharmacol. profiles at α₁-adrenoceptor subtypes (α_1A, α_1B and α_1D) by functional experiments and by in vitro binding studies at human cloned 5-HT_1A receptor. I (R = H) was identified as a α_1D antagonist (pK_bα_1D = 7.59; α_1D/α_1A > 389; α_1D/α_1B = 135) with high selectivity over 5-HT_1A receptor (5-HT_1A/α_1D < 0.01), while II (R = Cl) was characterized as a 5-HT_1A receptor ligand, highly selective over α_1D-adrenoceptor subtype (pK_i5-HT_1A = 8.04; 5-HT_1A/α_1D = 1096). Further pharmacol. studies demonstrated that II (R = Cl) was a partial agonist at 5-HT_1A receptor (E_max = 23, pD₂ = 6.92). In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Reference of 4360-63-8).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 4360-63-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

New generation dopaminergic agents. 6. Structure-activity relationship studies of a series of 4-(aminoethoxy)indole and 4-(aminoethoxy)indolone derivatives based on the newly discovered 3-hydroxyphenoxyethylamine D₂ template was written by Mewshaw, Richard E.;Webb, Michael B.;Marquis, Karen L.;McGaughey, Georgia B.;Shi, Xiaojie;Wasik, Theodore;Scerni, Rosemary;Brennan, Julie A.;Andree, Terrance H.. And the article was included in Journal of Medicinal Chemistry in 1999.Related Products of 3308-94-9 This article mentions the following:

A series of 4-(aminoethoxy)indoles I [R₁ = CH₂Ph, (CH₂)₄Ph, n- Bu, etc.; R₂ = H, Me; NR₁R₂ = isoquinolino; X = H, Cl, Y = H, COCF₃, Cl] and a related series of 4-(aminoethoxy)indolones II [R₁ = Me, CH₂Ph, 2-naphthyl, etc.; R₂ = H, Me, (CH₂)₂, CH₂; X = H, Cl, F] were synthesized and evaluated for their affinity for both the high- and low-affinity agonist states (D₂^High and D₂^Low, resp.) of the dopamine (DA) D₂ receptor. The 4-aminoethoxy derivatives I and II were designed as bioisosteric analogs based on the phenol prototype 3-HOC₆H₄OCH₂CH₂NHCH₂Ph. The indolones II were observed to have high affinity for the D₂^High receptor. Comparison of their previously reported chroman analogs with the more flexible 4-(aminoethoxy)indoles revealed the chroman analogs to be more potent, whereas little loss in D₂^High affinity was observed when comparing the 4-(aminoethoxy)indolones with their resp. chroman analogs. Several regions of the phenoxyethylamine framework were modified and recognized as potential sites to modulate the level of intrinsic activity. A conformational anal. was performed and a putative bioactive conformation was proposed which fulfilled the D₂ agonist pharmacophore criteria based on the McDermed model. Structure-activity relationships gained from these studies have aided in the synthesis of D₂ partial agonists of varying intrinsic activity levels. These agents should be of therapeutic value in treating disorders resulting from hypo- and hyperdopaminergic activity, without the side effects associated with complete D₂ agonism or antagonism. In the experiment, the researchers used many compounds, for example, 2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9Related Products of 3308-94-9).

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane (cas: 3308-94-9) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Related Products of 3308-94-9

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Mass spectrometry of the acetal derivatives of selected generally recognized as safe listed aldehydes with ethanol, 1,2-propylene glycol and glycerol was written by Woelfel, Keith;Hartman, Thomas G.. And the article was included in ACS Symposium Series in 1998.Application In Synthesis of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol This article mentions the following:

The FEMA-GRAS list offers flavor chemists a repertoire of nearly 2000 chems. for use in compounding natural and synthetic flavors for the U.S. marketplace. Aldehydes constitute an important class of these potential flavorants and are widely utilized to impart specific nuances. Alcs. such as ethanol, 1,2-propylene glycol and glycerol are commonly employed as solvents in compounded flavor systems due to their low odor and miscibility in a wide range of aqueous and organic matrixes. However, alcs. and aldehydes react rapidly under anhydrous conditions to form acetal derivatives which often possess different sensory properties. This well known reaction is reversible and its equilibrium is influenced by time, temperature, pH and moisture content. Mass spectra of acetals are currently under represented in com. databases and few literature references are available. Our investigation involved a systematic mass spectrometric study of the acetal derivatives of selected GRAS aldehydes reacted with ethanol, 1,2-propylene glycol and glycerol. Aldehydes from different chem. classes representing saturated and unsaturated aliphatics, aromatics, heterocyclics, terpenoids and others were included for characterization. The corresponding acetals were synthesized, analyzed by GC-MS in electron ionization mode and their retention indexes on a non-polar (polydimethylsiloxane) capillary column were determined A database of mass spectra was produced which includes many previously unreported species. In total, over 60 individual mass spectra were recorded. The characteristic mass spectral fragmentation pathways for each class of acetal are described. In the experiment, the researchers used many compounds, for example, 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2Application In Synthesis of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol).

2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (cas: 68527-74-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of 2-Methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and application of nanoporous triple-shelled CuAl₂O₄ hollow sphere catalyst for atmospheric chemical fixation of carbon dioxide was written by Heydari, P.;Hafizi, A.;Rajabzadeh, M.;Karimi, M.;Khalifeh, R.;Rahimpour, M. R.. And the article was included in Journal of the Taiwan Institute of Chemical Engineers in 2020.Recommanded Product: (2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate This article mentions the following:

Herein, a copper-alumina spinel hollow sphere with a triple-shell structure developed and applied as a novel catalyst for the cycloaddition of CO₂ at atm. pressure. Different operating conditions such as reaction temperature, various solvents and reaction time were studied in this reaction. Besides, different epoxides were converted into corresponding substituted dioxolanones I [R = CH₂Cl, Ph, CH₂OC₆H₅, etc.] at 80°C, under bubbling of CO₂ at atm. pressure, a catalyst loading of 3 weight% and a reaction time of 24 h with isolated yields up to 100%. In addition, the kinetics of the reaction was investigated at different reaction temperatures by calculating the reaction rate constant and activation energy (based on the Arrhenius equation). The nanoporous triple-shell CuAl₂O₄ hollow microspheres reduce the mass transfer path of different reactant and product mols. along with better accessibility of interior active sites that improved the catalytic efficiency with suitable activity and remarkable cycling stability. In the experiment, the researchers used many compounds, for example, (2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5Recommanded Product: (2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate).

(2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate (cas: 13818-44-5) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: (2-Oxo-1,3-dioxolan-4-yl)methyl methacrylate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem